Is coverage of S. aureus necessary in cellulitis/erysipelas? A literature review

Karakonstantis, Stamatis

doi:10.1007/s15010-019-01382-7

Cited by 13 publications

(7 citation statements)

References 90 publications

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“…The recurrence rate after penicillin administration was lower than that after the administration of macrolides, quinolones, and aminoglycosides. The reason for this difference may be that most of the pathogens that cause erysipelas were more sensitive to penicillin and that the clearance rate of penicillin was higher; hence, the clinical effect was better [12]. Univariate analysis showed no significant differences in the incidence of cardio-cerebral-vascular diseases, lung diseases, and liver and kidney diseases between the two groups; this finding suggested that these factors were not directly related to the recurrence of erysipelas.…”

Section: Discussionmentioning

confidence: 92%

“…Second, the C-reactive protein (CRP) level and peripheral blood white blood cell (WBC) count were not investigated. This is because only one previous study showed differences in CRP and WBC between patients with erysipelas and those with recurrent erysipelas [18], but other studies showed no such differences [12,19]. In addition, a new study has elaborated the usefulness of CRP and differential (neutrophil) blood count for differentiating between erysipelas and S.aureus-mediated cellulitis [20].…”

Section: Discussionmentioning

confidence: 99%

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Risk factors of recurrent erysipelas in adult Chinese patients: a prospective cohort study

Wang

et al. 2021

BMC Infect Dis

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Background Erysipelas is a common skin infection that is prone to recur. Recurrent erysipelas has a severe effect on the quality of life of patients. The present study aimed to investigate the risk factors of recurrent erysipelas in adult Chinese patients. Methods A total of 428 Chinese patients with erysipelas who met the inclusion criteria were studied. The patients were divided into the nonrecurrent erysipelas group and the recurrent erysipelas group. Clinical data were collected on the first episode and relapse of erysipelas. The patients were followed up every 3 months. Statistical analysis was performed to analyze and determine the risk factors of erysipelas relapse. Results Univariate analysis was performed to analyze the data, including surgery, types of antibiotics administered in the first episode, obesity, diabetes mellitus, venous insufficiency, lymphedema, and malignancy. The differences between the groups were statistically significant (p < 0.05). The Cox proportional hazards regression model analysis showed that the final risk factors included surgery, obesity, diabetes mellitus, venous insufficiency, and lymphedema. Conclusions Surgery, obesity, diabetes mellitus, venous insufficiency, and lymphedema are considered as risk factors for recurrent erysipelas.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Risk factors of recurrent erysipelas in adult Chinese patients: a prospective cohort study

Wang

et al. 2021

BMC Infect Dis

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“…Hierbei ist stark umstritten, ob in diesen Fällen Staphylococcus aureus tatsächlich als ursächlicher Erreger angesehen werdenkann [7]. EinErysipel beiNeugeborenen ist oft auf Gruppe-B-Streptokokken (Streptococcus agalactiae) zurückzuführen, welche ebenfalls für viele perianale und -vaginale Erysipele insbesondere bei Schwangeren ursächlich sind [8].…”

Section: » Ein Nachweis Des Erregers Gelingt Seltenunclassified

Pathogenese, Klinik und Therapie des Erysipels

Borst

Symmank

2022

hautnah

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ZusammenfassungDas Erysipel ist eine häufig vorkommende, akut auftretende, bakterielle Infektion der Haut, welche oft mit Systemzeichen einhergeht. Ursächlich für diese häufige Dermatose sind zumeist β‑hämolysierende Streptokokken der Gruppe A (Streptococcus pyogenes). Typischerweise dringen Bakterien durch einen Substanzdefekt in die Haut ein und siedeln sich in den superfiziellen Lymphgefäßen der Dermis an. Das Erysipel tritt üblicherweise an der unteren Extremität auf, kann aber jedes Körperareal betreffen. Klinisch zeichnet es sich durch eine Rötung mit flammenartigen Ausläufern, einer Schwellung und Überwärmung des betroffenen Areals aus. Die Rötung kann aufgrund der Oberflächlichkeit des Entzündungsprozesses in der Regel gut von gesundem Gewebe abgegrenzt werden. Im Bereich des respektiven Lymphabstromgebiets kann es zu einer reaktiven Lymphadenopathie kommen. Darüber hinaus können sich die Patienten mit Fieber, Schüttelfrost und Tachykardie präsentieren. Laborchemisch zeichnet sich die Erkrankung durch eine Erhöhung der Leukozytenzahl mit Neutrophilie, des C‑reaktiven Proteins und der Blutsenkungsgeschwindigkeit aus. Therapeutisch kommt Penicillin zum Einsatz, wobei Clindamycin eine bewährte Therapiealternative darstellt. Das Erysipel heilt meist komplikationslos ab, allerdings können sich chronisch-rezidivierende Verläufe etablieren.

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“… 1 , 2 GAS causes 5% to 10% of pharyngotonsillitis cases in adults and up to 37% in children older than 5 years; it also causes cutaneous infections. 3 , 4 GAS can lead to invasive infections such as bacteremia, streptococcal toxic shock syndrome, pneumonia, osteomyelitis, mastoiditis, and necrotizing fasciitis. The incidence of invasive GAS infection in developed countries is 2.3 to 6.2/100 000 and the fatality rate for streptococcal toxic shock syndrome is 30% to 60%.…”

Section: Introductionmentioning

confidence: 99%

Severe acute otitis media and mastoiditis caused by group A beta‐hemolytic streptococcus

Laakso

Rissanen

Ruotsalainen

et al. 2021

Laryngoscope Investig Oto

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Objective: To describe the characteristics, diagnostics, treatment, and outcome of severe acute otitis media (AOM) and acute mastoiditis (AM) caused by group A betahemolytic streptococcus (GAS). Study design:A retrospective cohort study. Methods:The yearly incidence of inpatient care-needing GAS AOM/AM patients in our hospital catchment area between 2002 and 2018 was investigated. A detailed analysis was performed for cases treated during the last GAS epidemic in 2017-2018. Anamnesis, signs and symptoms, pure-tone audiometry results, treatment, complications, and outcome were collected from medical charts. Patients responded to an otology-specific health-related quality of life survey (EOS-16) 1.5 to 3 years after their treatment. Results:The number of GAS infections peaks at approximately 7-year intervals. During 2017 and 2018, altogether 37 patients (29 adults and 8 children) were hospitalized due to GAS AOM/AM. AM was diagnosed in 14 (38%) patients. The disease progression was typically very rapid. At presentation, all patients had severe ear pain, 68% tympanic membrane perforation and discharge, 43% fever, and 43% vertigo. In pure-tone audiometry, there was usually a marked mixed hearing loss at presentation. There was a significant recovery in both air and bone conduction thresholds; the pure tone average improvement from presentation was 32.3 ± 14.8 dB. Rapid strep tests (RST) proved to be more sensitive than bacterial culture in identifying GAS as a cause of AOM/AM. Conclusion: GAS AOM/AM has a rapid onset. Hearing loss usually includes a sensorineural component, which is usually reversible with adequate treatment. RST seems to be useful in detecting GAS from middle ear discharge.

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Is coverage of S. aureus necessary in cellulitis/erysipelas? A literature review

Cited by 13 publications

References 90 publications

Risk factors of recurrent erysipelas in adult Chinese patients: a prospective cohort study

Risk factors of recurrent erysipelas in adult Chinese patients: a prospective cohort study

Pathogenese, Klinik und Therapie des Erysipels

Severe acute otitis media and mastoiditis caused by group A beta‐hemolytic streptococcus

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