Is chronic kidney disease, a predictor of in-hospital mortality in Coronavirus Disease 2019 (COVID-19) patients?

Moeinzadeh, Firouzeh; Raeisi, Vahideh; Babahajiani, Media; Mortazavi, Mojgan; Pourajam, Samaneh; Seirafian, Shiva; Shirzadi, Mohammad; Taheri, Shahram; Salahi, Mehrdad; Mansourian, Marjan; Toghyani, Arash; Zamani, Zahra

doi:10.4103/abr.abr_352_21

Cited by 2 publications

(1 citation statement)

References 25 publications

(30 reference statements)

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“…The association of CKD as a factor that can increase time-to-negative swab, to our knowledge, is a new and relevant factor. In fact, previously, several studies showed that patients with CKD had higher mortality and worse outcome compared with patients without [ 28 – 30 ], but, to our knowledge, no studies showed the impact of CKD on the time-to-negative swab. The persistence of SARS-CoV-2 in patients with CKD observed in the present study could be related to an alteration in the immune system due to renal impairment [ 31 ].…”

Section: Discussionmentioning

confidence: 86%

Clinical and epidemiological factors causing longer SARS-CoV 2 viral shedding: the results from the CoviCamp cohort

Grimaldi,

Russo,

Pisaturo

et al. 2023

Infection

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Introduction The aim of this study was to investigate how long hospitalized patients stayed positive to the nasopharyngeal swab, and what demographic and clinical factors influence the time-to-negative swab. Methods We enrolled in a multicenter, observational, retrospective study involving 17 COVID-19 units in eight cities of the Campania, southern Italy all patients hospitalized from March 2020 to May 2021 diagnosed with Severe Acute Respiratory Distress Syndrome-Coronavirus-2 (SARS-CoV-2) infection for whom time-to-negative swab was available. Results 963 patients were enrolled. We defined three groups considering time-to-negative swab: the first including patients with time-to-negative swab before the 26th day, the second including patients with time-to-negative swab from day 26 to day 39, and the third including patients with time-to-negative swab > 39 days. 721 (74.9%) patients belonged to the first group, 194 (20.1%) to the second, and 52 (5.4%) belonged to the third group. Belonging to group 2 and 3 seemed to be influenced by age (p value < 0.001), Charlson comorbidity index (p = 0.009), arterial hypertension (p = 0.02), cardiovascular disease (p = 0.017), or chronic kidney disease (CKD) (p = 0.001). The multivariable analysis confers a leading role to CKD, with an odds ratio of 2.3 as factor influencing belonging to the groups showing a longer time-to-negative swab. Patients with CKD and diabetes were more frequently in the third group. Discussion Our analysis showed that CKD is a factor related to longer time-to-negative swab, probably because of immunosuppression related to this condition.

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Section: Discussionmentioning

confidence: 86%