Is choroidal thickness related with disease activity and joint damage in patient with rheumatoid arthritis

Kurt, Ali; Kurt, Emine Eda; Kılıç, Raşit; Öktem, Çağlar; Tuncay, Figen; Erdem, Hatice Rana

doi:10.4149/bll_2017_005

Cited by 8 publications

(5 citation statements)

References 27 publications

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Section: Vasculitis Associated With Systemic Diseasementioning

confidence: 68%

“…In contrast to the Duru et al 's study [130], Kurt et al [132] reported a significantly thinner choroid in patients with active disease than patients in remission. However, consistent with Duru et al 's results, a relationship between activity level and CT has not been shown [132]. Contrary to these studies reporting a thinner choroid in RA patients, there is one study showing no difference [133] and another stating a significantly increased CT which was positively correlated with rheumatoid factor [134].…”

Section: Vasculitis Associated With Systemic Diseasementioning

confidence: 68%

“…Most of the studies evaluating CT in RA patients revealed a thinner choroid in RA patients compared to healthy controls [116,[130][131][132]. It has been postulated that the possible reason for this thinning was the vascular involvement causing chronic vascular damage in the choroid.…”

Section: Vasculitis Associated With Systemic Diseasementioning

confidence: 99%

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Choroidal involvement in systemic vasculitis: a systematic review

Özdal

Tuğal-Tutkun

2022

J Ophthal Inflamm Infect

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Systemic vasculitides are a large group of heterogeneous diseases characterized by inflammatory destruction of blood vessels targeting diverse organs and tissues including the eye. As the most vascularized layer of the eye, the choroid is expected to be affected in multiple systemic rheumatologic diseases with vascular involvement. While there are plenty of studies investigating retinal vascular involvement, choroidal vascular involvement in systemic vasculitides has not been investigated in isolation. However, choroidal manifestations including thickness changes, choroidal vasculitis and ischemia may be the earliest diagnostic features of systemic vasculitic diseases. Thus, multimodal imaging of the choroid may help early detection of choroidal involvement which may also have prognostic implications in these life-threatening diseases. This article aimed to review involvement of the choroid in systemic vasculitic diseases.

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Section: Vasculitis Associated With Systemic Diseasementioning

confidence: 68%

Section: Vasculitis Associated With Systemic Diseasementioning

confidence: 68%

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Choroidal involvement in systemic vasculitis: a systematic review

Özdal

Tuğal-Tutkun

2022

J Ophthal Inflamm Infect

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“…Kurt et al demonstrated decreased corneal thickness (CT) of 59 RA patients compared to healthy controls. However, no significant correlation was found between CT measurements and Disease Activity Score 28 (DAS 28) or Larsen disease activity scores [8].…”

Section: Choroidmentioning

confidence: 97%

Ocular manifestations of rheumatic diseases

Kemény-Beke

Szodoray

2019

Int Ophthalmol

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Purpose Our aim was to summarize key aspects of the pathomechanism and the ocular involvements of rheumatic and systemic autoimmune diseases. Methods Apart from a paper in French (Morax V, Ann Oculist 109:368-370, 1893), all papers referred to in this article were published in English. All the materials were peer-reviewed full-text papers, letters, reviews, or book chapters obtained through a literature search of the PubMed database using the keywords ocular manifestations; pathogenesis; systemic inflammatory rheumatic diseases; rheumatoid arthritis; osteoarthritis; fibromyalgia; systemic lupus erythematosus; seronegative spondyloarthritis; ankylosing spondylitis; reactive arthritis; enteropathic arthritis; psoriatic arthritis; systemic sclerosis; polymyalgia rheumatica and covering all years available. Some statements articulated in this paper reflect the clinical experience of the authors in their tertiary-referral center. Results Ophthalmic disorders are categorized by anatomical subgroups in all rheumatic diseases. The most common ocular manifestations are diverse types of inflammations of different tissues and dry eye disease (DED). Conclusion The eye could be a responsive marker for the onset or aggravation of an immune reactivation in many rheumatic diseases, furthermore, ocular findings can antedate the diagnosis of the underlying rheumatic disease. By recognizing ocular manifestations of systemic rheumatic diseases it might be possible to avoid or at least delay many long term sequelae.

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“…Melanin, produced in melanocytes in the choroidal layer and stored in melanosomes, has a crucial role in protecting and absorbing light from intraocular reflection (4). There are a limited number of studies showing that the affected choroid is also affected in vitiligo in some systemic inflammatory diseases (5,7).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the retinal nerve fiber layer thickness and the choroidal thickness in generalized vitiligo patients

Satici

Aksoy

2020

Preprint

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Aim: The retinal nerve fiber layer (RNFL) thickness and the choroidal thickness is compared to healthy volunteers in vitiligo patients. Material and method: The study included the right eyes of 60 healthy individuals and 60 generalized vitiligo patients. Following routine ophthalmological examination, the RNFL thickness and the choroidal thickness were analyzed with spectral domain optical coherence tomography (SD-OCT). Results: It was determined that the mean macular choroidal thickness decreased significantly in vitiligo patients, while the RNFL thickness did not change (p<0.05). Conclusion: As the fact that the RNFL thickness does not change despite the significantly reduced choroidal thickness in vitiligo patients may indicate that the melanin cells that are dense in the choroid are affected, the non-invasive, simple and rapid measurement of the choroidal thickness with OCT can help in determining the damage in vitiligo patients. Keywords: Vitiligo, choroid, nerve fibers, optical coherence tomography. 1. What is already known about this topic? Melanocytes are found in uveal tissues such as the eyelash, retinal pigment epithelium, choroid, ciliary body, and iris. Melanin in these tissues can disappear when destruction occurs in cutaneous melanocytes in vitiligo patients. As a result, some studies reported hypopigmented spots on the iris and retina, atrophic changes in the peripapillary area, degeneration in the retinal pigment epithelium and chorioretinal areas. Melanin, produced in melanocytes in the choroidal layer and stored in melanosomes, has a crucial role in protecting and absorbing light from intraocular reflection. 2. What does this article add? Although the visual acuity of the patients with vitiligo is at the same level as the control group, we found that the average macular choroid thickness was thinner. We found no significant changes in the choroidal thickness in patients with periocular attitude. We found a negative correlation between the choroidal thickness and the duration of the disease.

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Is choroidal thickness related with disease activity and joint damage in patient with rheumatoid arthritis

Cited by 8 publications

References 27 publications

Choroidal involvement in systemic vasculitis: a systematic review

Choroidal involvement in systemic vasculitis: a systematic review

Ocular manifestations of rheumatic diseases

Evaluation of the retinal nerve fiber layer thickness and the choroidal thickness in generalized vitiligo patients

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