Ocular manifestations of rheumatic diseases

Kemény-Beke, Ádám; Szodoray, Péter

doi:10.1007/s10792-019-01183-9

Cited by 60 publications

(62 citation statements)

References 43 publications

(41 reference statements)

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“…An association between SS and ankylosing spondylitis was also described, with a prevalence of 10% (6). On the contrary, the association of PsA and SS has been rarely described and, according to our knowledge, a total of 18 probable cases have been reported (7)(8)(9)(10)(11)(12).…”

Section: N Discussion and Conclusionmentioning

confidence: 86%

Psoriatic spondyloarthritis and Sjögren syndrome: a casual association?

et al. 2020

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The association between Sjögren syndrome (SS) and psoriatic arthritis (PsA) is rare. Herein, we report a case of SS in a PsA patient with the mutilans variant. A 67-year old woman developed PsA with progressive articular destruction up to the typical deformation of ‘telescoping fingers’ in the distal phalanges. Psoriatic onychopathy presented ten years after the osteolytic damage in the hands. This late appearance led to delayed diagnosis and therapy, and, consequently, worsened the articular destruction. Thereafter, the patient developed a typical SS with clinical symptoms, such as xerophthalmia and xerostomia. This diagnosis was confirmed by positive diagnostic tests, such as Schirmer test, ANA, and anti-SSA/Ro and anti-SSB/La antibodies. A potential association between the two diseases is discussed.

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Section: N Discussion and Conclusionmentioning

confidence: 86%

Psoriatic spondyloarthritis and Sjögren syndrome: a casual association?

et al. 2020

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“…DED is the most common eye pathology because this disease can emerge as a primary phenotype; that is, a local immune response is generated and sustained in the ocular surface and draining lymph nodes [9]. DED is also found as a secondary phenotype, where both autoinflammatory (e.g., colitis) [10,11] and autoimmune diseases (Sjögren's syndrome, rheumatoid arthritis, and lupus) present DED symptoms [12][13][14]. The relevant finding that DED onset precedes autoimmune and non-autoimmune diseases in several patients is puzzling, and it has attracted interest from researchers worldwide, but the pathways remain to be elucidated.…”

Section: Dry Eye Diseasementioning

confidence: 99%

Lymphocytes in Dry Eye Disease

Vázquez-Mendoza¹,

Vannan²,

Morales³

et al. 2022

Dry Eye Syndrome - Modern Diagnostic Techniques and Advanced Treatments

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The eye is a delicate organ that, along with other tissues such as the testicles and brain, is considered immune-privileged. Immune cells that reside in the eye must create a tolerogenic microenvironment to prevent unwanted aggressive inflammatory reactions that can compromise function. However, the eye is exposed to persistent environmental insult that may overwhelm immune tolerance and result in eye diseases from diverse origins (autoimmune, infectious, and inflammatory). The immune system plays a central role in the different phases of eye diseases, as alterations in immune cells in response to mechanical, chemical, or infectious stimuli initiate and amplify the immune response that lead to ocular tissue damage. Both resident and infiltrating immune cells also actively inhibit the immune response and promote tissue repair. Emerging evidence is leading to a better understanding of how and when lymphocytes, amongst other immune cells, contribute to inflammatory diseases such as dry eye disease (DED). We have compiled literature identifying the presence and participation of lymphocyte subpopulations that modulate DED from studies in both mice and humans. Notably, most mouse studies have relied on desiccant-stress-induced models (non-autoimmune DED), whereas human studies are predominantly in patients with Sjögren’s syndrome (autoimmune DED).

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“…Mouse models of Sjὃgren syndrome. Sjὃgren syndrome, the most common autoimmune disease in humans, is characterized by mononuclear cell infiltration of the salivary and lacrimal glands (LGs) (3,4). There are several mouse models of Sjὃgren syndrome, each recapitulating one or more of its aspects, but none is perfect.…”

Section: Mouse Models Of Dedmentioning

confidence: 99%

Animal models of dry eye disease: Useful, varied and evolving (Review)

et al. 2021

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Dry eye disease (DED), which is a prevalent disease that still lacks successful treatment options, remains a major challenge in ophthalmology. Multiple animal models of DED have been used to decipher its pathophysiology and to develop novel treatments. These models use mice, rats, rabbits, cats, dogs and non-human primates. Each model assesses aspects of DED by focusing on elements of the lacrimal functional unit, which controls the homeostasis of the tear film. The present review outlines representative DED animal models and assesses their contribution to the study of DED. Murine models are the most extensively used, followed by rabbit models; the latter offer the advantage of larger eyes, a favorable biochemical profile for drug studies, experimental ease and relatively low cost, contrasting with non-human primates, which, although closer to humans, are not as accessible and are expensive. No comprehensive ‘ideal’ animal model encompassing all aspects of human DED exists nor is it feasible. Investigators often choose an animal model based on their experimental needs and the following four features of a given model: The size of the eye, its biochemical composition, the available research reagents and cost. As research efforts in DED expand, more refined animal models are needed to supplement the enormous contribution made to date by existing models.

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Ocular manifestations of rheumatic diseases

Cited by 60 publications

References 43 publications

Psoriatic spondyloarthritis and Sjögren syndrome: a casual association?

Psoriatic spondyloarthritis and Sjögren syndrome: a casual association?

Lymphocytes in Dry Eye Disease

Animal models of dry eye disease: Useful, varied and evolving (Review)

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