Is Carcinoma of the Prostate Less Serious in Older Men?

Rosenberg, Stanley

doi:10.1111/j.1532-5415.1965.tb02059.x

Cited by 35 publications

(6 citation statements)

References 23 publications

(25 reference statements)

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“…The notion that early age at onset is associated with worse prognosis was common among physicians in the pre-PSA era. It was also the subject of several early European and U.S. studies 8, 9, 12, 13, 27, 29–33 , including large population-based cancer registry cohorts in the U.S. 31 , Sweden 8 , and Scotland 27 .…”

Section: Incidence and Mortality In Young Men With Prostate Cancermentioning

confidence: 99%

Prostate cancer in young men: an important clinical entity

et al. 2014

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Prostate cancer is considered a disease of older men, but today over 10% of new diagnoses occur in U.S. men ≤ 55 years. Early onset prostate cancer, i.e., diagnosed at ≤55 years, differs from prostate cancer in older men in several ways. Among men diagnosed with high grade and stage prostate cancer, men with early onset prostate cancer are more likely to die of their cancer, with higher cause-specific mortality than all others except those diagnosed over age 80. This suggests that important biological differences may exist in early onset disease compared to late onset disease. Furthermore, early onset prostate cancer has been shown to have a more significant genetic component indicating that this group may benefit more than most from evaluation of genetic risk. Clinically, although the majority of cases ≤ 55 years are diagnosed with low risk disease, their extended life expectancy exposes them to long-term risk of disease progression resulting in death from prostate cancer, but also to prolonged impact from treatment-related morbidities. These patients pose unique challenges and opportunities for both the research and clinical communities. We therefore suggest that early onset prostate cancer is a distinct phenotype, from both an etiologic and clinical perspective, that deserves further attention.

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Section: Incidence and Mortality In Young Men With Prostate Cancermentioning

confidence: 99%

Prostate cancer in young men: an important clinical entity

et al. 2014

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“…Age as a prognostic factor has also been controversial. There have been indications that younger patients have more aggressive tumors [20, 21] and higher local failure rates [17]. In the present study, age was a prognostic factor on univariate analysis only for FFR and DSS, with patients less than 70 years old faring poorer than those older than 70.…”

Section: Discussionmentioning

confidence: 47%

Limitations of reduced-field irradiated volume and technique in conventional radiation therapy of prostate cancer:Implications for conformal 3-D treatment

et al. 2000

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In order to define technical limitations of conventional external beam irradiation for clinically localized prostate cancer, we evaluated the impact of several reduced‐field treatment factors, such as reduced‐field (RF) irradiated volume, RF technique, photon energy of treatment, and dose on survival endpoints and local control in a retrospective series. Several survival endpoints, such as disease‐specific survival, freedom from relapse survival, biochemical no‐evidence of disease (bNED) survival, and local control were associated with several treatment variables using univariate and multivariate analyses in 329 patients. Reduced‐field technique appeared to predict survival outcome, with patients treated by bilateral 120° arcs faring less well than those treated by full 360° rotational fields. The irradiated volume of the reduced‐field was also significantly associated with survival outcome, with patients treated with smaller volumes faring less well. Local failure rates also appeared increased, although not statistically, in patients treated with smaller RF sizes. In an attempt to explain these detected deficiencies, dose‐volume histograms for prostate coverage were created for a small sample of patients. The deficiencies related to small reduced‐field volume appeared to be largely attributable to poor dosimetric coverage of the prostate. These results underscore the limitations of conventional external beam treatment for prostate carcinoma when conventional techniques are employed, particularly if small reduced fields are used, and further supports the development of improved treatment techniques, such as conformal irradiation, as alternatives. Int. J. Cancer (Radiat. Oncol. Invest.) 90:265–274, 2000. © 2000 Wiley‐Liss, Inc.

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“…Since this activity is higher in the more malignant grades, the suggestion that prolactin might play a role in the pathogenesis of carcinoma of the prostate was brought forth.” While the incidence of prostatic carcinoma varies according to the number of sections taken and the willingness of pathologists to make this diagnosis in the absence of capsular or perineural space invasion, it is apparent that its frequency tends to approach that of D.H. ( vide supra ). Although prostatic carcinoma accounts for only 1.4 per cent of all deaths in men over 50 years of age, its incidence in this age group is considerably higher—ranging from 13 to 46 per cent, and averaging 20.3 per cent (87)—there being an increasing tendency towards latency with age (88). Takahashi (89) reported a significant correlation between sugar consumption and prostatic cancer. In view of the diabetogenic effect of caffeine (90), the finding of a significant correlation between the average consumption of coffee and the age‐adjusted mortality due to prostatic cancer in 20 non‐coffee producing countries (89) assumes relevance.…”

Section: Altered Intermediary Metabolism In the Pathogenesis Of Prostmentioning

confidence: 99%

The Role of Diabetogenic Hyperinsulinism in the Pathogenesis of Prostatic Hyperplasia and Malignancy*

Roberts

1966

J American Geriatrics Society

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Is Carcinoma of the Prostate Less Serious in Older Men?

Cited by 35 publications

References 23 publications

Prostate cancer in young men: an important clinical entity

Prostate cancer in young men: an important clinical entity

Limitations of reduced-field irradiated volume and technique in conventional radiation therapy of prostate cancer:Implications for conformal 3-D treatment

The Role of Diabetogenic Hyperinsulinism in the Pathogenesis of Prostatic Hyperplasia and Malignancy*

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