The Role of Diabetogenic Hyperinsulinism in the Pathogenesis of Prostatic Hyperplasia and Malignancy*

Delayed Thrombophlebitis and Systemic Complications After Vasectomy: Possible Role of Diabetogenic Hyperevsulinism*

“…In fact, most of the patients in our series complained of narcolepsy, migraine and spontaneous leg cramps—symptoms commonly due to severe reactive hypoglycemia (3–5, 39–41). The development of multiple sclerosis shortly after vasectomy in Case 6 assumes increased significance in view of the following considerations: (a) diabetogenic hyperinsulinism may be a major factor in the pathogenesis of multiple sclerosis (39); and (b) the hyperinsulinized state can be potentiated by testosterone (42), which undoubtedly is released into the testicular tissues—and from there into the systemic circulation—in abnormal amounts following vasectomy. It has been further demonstrated by many investigators that diabetics generally elaborate excessive amounts of biologically‐active insulin.…”

“…There may be marked differences in the immunologic responsiveness to vasectomy by different populations, for nutritional and other ecologic reasons. For example, there is considerable evidence that the diathesis to the hyperinsulinized state is enhanced in the United States by ingestion of large amounts of sugar and abundant calories (42, 55, 56). The metabolic and tumorigenic effects of androgenic action in the hyperinsulinized state also have been detailed previously (42).…”

“…For example, there is considerable evidence that the diathesis to the hyperinsulinized state is enhanced in the United States by ingestion of large amounts of sugar and abundant calories (42, 55, 56). The metabolic and tumorigenic effects of androgenic action in the hyperinsulinized state also have been detailed previously (42). Furthermore, in the United States the routine mass immunization to multiple diseases and the repeated exposure to various drugs have activated the population's immune and insulinogenic mechanisms to a high degree.…”