Is body mass index associated with symptom severity and health-related quality of life in irritable bowel syndrome? A cross-sectional study

Dong, Yuanjun; Berens, Sabrina; Eich, Wolfgang; Schaefert, Rainer; Tesarz, Jonas

doi:10.1136/bmjopen-2017-019453

Cited by 12 publications

(9 citation statements)

References 28 publications

(27 reference statements)

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“…A survey carried out in an outpatient setting in Germany between 2011 and 2016 showed that 59.0% of patients with IBS were in the normal weight range, 30.3% were overweight or obese, and 10.7% were underweight. 32 The proportion of obese linaclotide users in the United Kingdom and in Spain is consistent with the figures reported in Germany. Obese patients who potentially used linaclotide to help with weight loss could not be distinguished in our study from obese patients who used linaclotide to treat IBS-C.…”

Section: Discussionsupporting

confidence: 83%

Linaclotide utilization and potential for off-label use and misuse in three European countries

Cid-Ruzafa¹,

Lacy

Schultze

et al. 2022

Therap Adv Gastroenterol

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Introduction: Linaclotide is approved for adults with moderate-to-severe irritable bowel syndrome (IBS) with constipation (IBS-C). Linaclotide is not indicated for weight loss or for patients with inflammatory bowel disease (IBD); it is contraindicated in patients with mechanical bowel obstruction (MBO). Some patients with obesity or eating disorders (ED) may use linaclotide off-label for weight loss or as a laxative. Objectives: To describe the use of linaclotide in clinical practice, including patients with potential for off-label use or misuse. Methods: Post-authorization safety study conducted in three databases from the linaclotide launch date to 2017: the Clinical Practice Research Datalink in the United Kingdom (UK), the Information System for Research in Primary Care database in Spain and the linked Patient, Prescription and Causes of Death Registries in Sweden. Cohorts of patients were identified as having IBS using diagnostic and treatment codes; IBS subtypes were identified using symptoms and treatment codes; patients with obesity, ED, MBO, and IBD were identified using diagnostic codes or body mass index. Results: There were 1319, 1981, and 5081 linaclotide users from the United Kingdom, Spain, and Sweden with a median age of 45, 57, and 51 years, respectively; most were females. In the United Kingdom, Spain, and Sweden, respectively: 59.0%, 60.3%, and 31.3% of linaclotide users had an IBS diagnosis recorded, and among those, 68.8%, 61.3%, and 92.7% were classified as IBS-C. The proportions of linaclotide users considered at risk for potential off-label use for weight loss or as a laxative were 17.1%, 29.7%, and 1.7%, and the proportions of users considered at risk of misuse due to a history of MBO or IBD were 3.5%, 4.6%, and 5.7% in the United Kingdom, Spain, and Sweden, respectively. Conclusions: Potential linaclotide off-label use and misuse appears limited, as evidenced by the small sizes of the patient subgroups at risk for off-label use and misuse.

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Section: Discussionsupporting

confidence: 83%

Linaclotide utilization and potential for off-label use and misuse in three European countries

Cid-Ruzafa¹,

Lacy

Schultze

et al. 2022

Therap Adv Gastroenterol

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“…This rate was much lower in the British study, where it was around 6%. (10) A quarter of our patients had a history of visceral and/or gynecological surgery. The association between IBS and a history of surgery was demonstrated in a study by the American Gastroenterological Association in 2004, which found that IBS was associated with a 3-fold increased risk of cholecystectomy, appendectomy and hysterectomy (11).…”

Section: Resultsmentioning

confidence: 99%

Quality of life of patients with functional bowel disorders

Zaimi

Trabelsi

Shimi

et al. 2022

Preprint

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“…The effect of IBS on quality of life has been examined in various studies; gender 26 , age 27 , anxiety level 28,29 , depression level 26 , BMI 30,31 have all been evaluated. In contrast to our study, Tang et al 32 found that women with IBS had lower IBS-QOL scores (74.09 ± 8.06) than men (80.40 ± 6.62).…”

Section: Discussionmentioning

confidence: 99%

“…Unlike other studies, in our study, no significant correlation was found between IBS-QOL scores and PSS-14 scores. Being overweight is a common phenomenon in patients with IBS 30 . The association between QOL and symptom severity followed a negative dose-response pattern.…”

Section: Discussionmentioning

confidence: 99%

Quality of life, perceived stress and nutrition of patients with irritable bowel syndrome: A descriptive study

Celik

Aktaç

Sabuncular

et al. 2022

Nor. Afr. J. Food Nutr. Res.

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Background: Irritable Bowel Syndrome (IBS) is a chronic and common functional bowel disorder that currently has no definite treatment. Depending on the type and severity of the individual's symptoms, medication, diet, and/or lifestyle changes are recommended. Aims: This study aimed to determine the relationship between the quality of life, perceived stress levels, and nutrition of individuals diagnosed with IBS. Subjects and Methods: Between March 2020 and March 2021, 340 patients with IBS volunteered for this study. The demographic information questionnaire, Irritable Bowel Syndrome Quality of Life (IBS-QOL) scale, Perceived Stress Scale-14 (PSS-14), and Food Frequency Questionnaire were applied via an online form. Results: From the 340 patients, 230 were eligible. Out of them, 27% followed a special diet for IBS. When the IBS-QOL scores of men were compared according to their educational status, the scores of those with a high school or higher education level (109.7±32.8) were found to be higher than those with a lower education level than high school (95.4±17.5) (p=0.008), while the educational status of women did not affect the IBS-QOL scores (p>0.05). The mean IBS-QOL score of men was 44.8 ± 20.1 and lower than women (50.9±21.7) (p=0.030). The mean IBS-QOL score of women following an IBS-specific diet was 57.6 ± 22.6 and higher than women who did not follow an IBS-specific diet (48.2±20.9) (p=0.023). The IBS-QOL scores of women with gluten or lactose intolerance were lower than women without any intolerances (p=0.004). The mean IBS-QOL score for women with lactose intolerance was higher than those with gluten intolerance (p=0.004). When the IBS-QOL scores were evaluated according to the frequency of food consumption, no significant differences were found in the food groups (p>0.05). In this study, no significant correlation was found between IBS-QOL scores and PSS-14 scores (p>0.05). Conclusions: The prediction equations developed for healthy populations are not accurate enough to determine the energy requirements in SCD. Keywords: Irritable bowel syndrome, nutrition, stress, quality of life, patients.

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Is body mass index associated with symptom severity and health-related quality of life in irritable bowel syndrome? A cross-sectional study

Cited by 12 publications

References 28 publications

Linaclotide utilization and potential for off-label use and misuse in three European countries

Linaclotide utilization and potential for off-label use and misuse in three European countries

Quality of life of patients with functional bowel disorders

Quality of life, perceived stress and nutrition of patients with irritable bowel syndrome: A descriptive study

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