Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion?

Debener, Stefan; Strobel, Alexander; Kürschner, Katharina; Kranczioch, Cornelia; Hebenstreit, Jörg; Maercker, Andreas; Beauducel, André; Brocke, Burkhard

doi:10.1016/s0301-0511(01)00132-6

Cited by 52 publications

(57 citation statements)

References 39 publications

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“…A similar result was reported by Kähkönen et al (2002) with MEG; in this study, the effect was significant only for the contralaterally stimulated ear (Kähkönen et al, 2002). However, in other studies ATD did not modulate the LDAEP (Debener et al, 2002;Massey et al, 2004;Norra et al, 2008;O'Neill et al, 2008).…”

Section: Loudness-dependent Auditory Evoked Potentialmentioning

confidence: 69%

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Kenemans

Kähkönen

2010

Neuropsychopharmacol

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This review surveys human event-related brain potential (ERP) and event-related magnetic field (ERF) approaches to psychopharmacology and psychopathology, and the way in which they complement behavioral studies and other neuroimaging modalities. The major paradigms involving ERP/ERF are P50 suppression, loudness-dependent auditory evoked potential (LDAEP), mismatch negativity (MMN), P300, mental chronometry, inhibitory control, and conflict processing (eg, error-related negativity (ERN)). Together these paradigms cover a range of more bottom-up driven to more top-down controlled processes. A number of relationships between the major neurotransmitter systems and electrocortical mechanisms are highlighted. These include the role of dopamine in conflict processing, and perceptual processing vs motor preparation; the role of serotonin in P50 suppression, LDAEP, and MMN; glutamate/NMDA and MMN; and the role of acetylcholine in P300 generation and memory-related processes. A preliminary taxonomy for these relationships is provided, which should be helpful in attuning possible new treatments or new applications of existing treatments to various disorders.

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Section: Loudness-dependent Auditory Evoked Potentialmentioning

confidence: 69%

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Kenemans

Kähkönen

2010

Neuropsychopharmacol

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“…15,110 In eight studies no data on the adequacy of the achieved depletion was reported. 15,32,40,110,111,118,119,123 In two studies insufficient depletion was attained. 94,115 In 10 studies no clear SDs or SEs were given for the observed mood effects.…”

Section: Identified Studiesmentioning

confidence: 98%

“…In five studies only other or undefined mood-scales were used. 40,51,76,85,86 Especially for the POMS and the VAS the direction of a decrease of mood in subjects was not always clearly reported. 52,68,77,85 In our meta-analysis no differential effect of the applied mood-scale was observed (Q res = 3.89, df = 2, P > 0.05; data not shown).…”

Section: Qualitative Summarymentioning

confidence: 99%

Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies

2007

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Dysfunction in the monoamine systems of serotonin (5-HT), norepinephrine (NE) and dopamine (DA) may causally be related to major depressive disorder (MDD). Monoamine depletion studies investigate the direct effects of monoamines on mood. Acute tryptophan depletion (ATD) or para-chlorophenylalanine (PCPA) deplete 5-HT, acute phenylalanine/ tyrosine depletion (APTD) or alpha-methyl-para-tyrosine (AMPT) deplete NE/DA. Available depletion studies found conflicting results in heterogeneous populations: healthy controls, patients with previous MDD in remission and patients suffering from MDD. The decrease in mood after 5-HT and NE/DA depletion in humans is reviewed and quantified. Systematic search of MEDLINE and EMBASE (1966-October 2006) and cross-references was carried out. Randomized studies applying ATD, PCPA, APTD or AMPT vs control depletion were included. Pooling of results by meta-analyses was stratified for studied population and design of the study (within or between subjects). Seventy-three ATD, 2 PCPA, 10 APTD and 8 AMPT studies were identified of which 45 ATD and 8 APTD studies could be meta-analyzed. 5-HT or NE/DA depletion did not decrease mood in healthy controls. 5-HT or NE/DA depletion slightly lowered mood in healthy controls with a family history of MDD. In drug-free patients with MDD in remission, a moderate mood decrease was found for ATD, without an effect of APTD. ATD induced relapse in patients with MDD in remission who used serotonergic antidepressants. In conclusion, monoamine depletion studies demonstrate decreased mood in subjects with a family history of MDD and in drug-free patients with MDD in remission, but do not decrease mood in healthy humans. Although depletion studies usefully investigate the etiological link of 5-HT and NE with MDD, they fail to demonstrate a causal relation. They presumably clarify a vulnerability trait to become depressed. Directions for further investigation of this vulnerability trait are proposed.

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“…For example, although there is some evidence that the loudness dependency of auditory event-related potentials (ERPs) is related to brain serotonin function, this measure is not altered by ATD. [29][30][31] While this raises the possibility that the loudness dependency of auditory ERPs is not related to serotonin function, the evidence is by no means definitive. Although there is increasing evidence, summarized in the paragraphs that follow, that ATD lowers serotonin function in brain areas related to the regulation of mood, this does not necessarily mean that it lowers serotonin function in brain areas related to the loudness dependency of auditory ERPs.…”

Section: Does Atd Lower Serotonin Function?mentioning

confidence: 99%

Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

Young

2013

J Psychiatry Neurosci

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Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion?

Cited by 52 publications

References 39 publications

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies

Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

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