Is Asian type MS an MS phenotype, an NMO spectrum disorder, or a MOG-IgG related disease?

Araújo, Ana Carolina Ribeiro de Araújo e; Nascimento, Anna Christiany Brandão; Araújo, Nadja; Meneguette, Nathalie Stéphanie; Neri, Vanderson Carvalho; Alvarenga, Marcos Papais; Filho, Hélcio Alvarenga; Barros, Priscila O.; Bento, Cleonice A.M.; Schmidt, Sergio L.; Vasconcelos, Cláudia Cristina Ferreira; Alvarenga, Regina Maria Papais

doi:10.1016/j.msard.2020.102082

Cited by 8 publications

(5 citation statements)

References 39 publications

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“…101 A growing body of evidence indicates that ethnicity might impact clinical manifestations of MS, possibly leading to different phenotypes of the disease. 102,103 Interestingly, despite not demonstrating an association with susceptibility to develop MS, some groups have observed that rs6897932 SNP is associated with greater disease severity. Kulakova and colleagues observed that, in their Russian cohort, MS patients that carried the T allele showed favorable manifestations of the autoimmune disorder (optic neuritis or sensory disturbances), whereas carriers of the C allele presented with manifestations that are associated with worse prognosis (eg, motor disorders, brain stem disorders, impaired coordination).…”

Section: Multiple Sclerosis (Ms) and Other Demyelinating Autoimmune Dmentioning

confidence: 99%

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent

Barros¹,

Berthoud²,

Aloufi³

et al. 2021

ITT

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Soluble cytokine receptors can influence immune responses by modulating the biological functions of their respective ligands. These effects can be either agonistic or antagonistic and a number of soluble cytokine receptors have been shown to play critical roles in both maintenance of health and disease pathogenesis. Soluble IL-7Ra (sCD127) is one such example. With its impact on the IL-7/CD127 pathway, which is fundamental for the development and homeostasis of T cells, the role of sCD127 in health and disease has been extensively studied in recent years. Within this review, the role of sCD127 in maintaining host immune function is presented. Next, by addressing genetic factors affecting sCD127 expression and the associated levels of sCD127 production, the roles of sCD127 in autoimmune disease, infections and cancer are described. Finally, advances in the field of soluble cytokine therapy and the potential for sCD127 as a biomarker and therapeutic agent are discussed.

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Section: Multiple Sclerosis (Ms) and Other Demyelinating Autoimmune Dmentioning

confidence: 99%

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent

Barros¹,

Berthoud²,

Aloufi³

et al. 2021

ITT

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“…In both entities, recurrences are likely. [12,14,16,28,29] Asian type MS shares demographic, MRI, and laboratory features with Multiple Sclerosis (MS) (09, 10,18]. Similarities between the ophthalmological evaluation of optic neuritis in Multiple Sclerosis (MS-ON) and OSMS-ON are expected.…”

Section: Discussionmentioning

confidence: 99%

“…The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist were used to assess study quality. [17] The neurologists made the OSMS patients' selection (RMPA, ACAA, MPA) in the Hospital da Lagoa, the principal reference center for demyelinating diseases in Rio de Janeiro (Brazil) [18]. OSMS patients consecutively attended in 2017 and 2018 were invited to perform the ophthalmologic examination in HUGG.…”

Section: Participants and Inclusion Criteriamentioning

confidence: 99%

Optic neuritis in Asian type opticospinal multiple sclerosis (OSMS-ON) in a non-Asian population: A functional-structural paradox

Meneguette

Almeida

Figueiredo

et al. 2021

Multiple Sclerosis and Related Disorders

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“…For MS atrophy, since general tests such as blood, urine, and cerebrospinal fluid show no abnormalities, information for diagnosis is collected by head MRI and myocardial scintigraphy. Head MRI shows atrophy of the cerebellum and pons, and atrophy of the basal ganglia, which are characteristic image findings called the "slit sign" and "cross sign" when viewed in a horizontal section [124].…”

Section: Methodsmentioning

confidence: 99%

Unraveling the Immunopathogenesis of Multiple Sclerosis: The Dynamic Dance of Plasmablasts and Pathogenic T Cells

Matsuzaka,

Yashiro

2023

Biologics

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Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, characterized by multiple lesions occurring temporally and spatially. Additionally, MS is a disease that predominates in the white population. In recent years, there has been a rapid increase in the number of patients, and it often occurs in young people, with an average age of onset of around 30 years old, but it can also occur in children and the elderly. It is more common in women than men, with a male-to-female ratio of approximately 1:3. As the immunopathogenesis of MS, a group of B cells called plasmablasts controls encephalomyelitis via IL-10 production. These IL-10-producing B cells, called regulatory B cells, suppress inflammatory responses in experimental mouse models of autoimmune diseases including MS. Since it has been clarified that these regulatory B cells are plasmablasts, it is expected that the artificial control of plasmablast differentiation will lead to the development of new treatments for MS. Among CD8-positive T cells in the peripheral blood, the proportion of PD-1-positive cells is decreased in MS patients compared with healthy controls. The dysfunction of inhibitory receptors expressed on T cells is known to be the core of MS immunopathology and may be the cause of chronic persistent inflammation. The PD-1+ CD8+ T cells may also serve as indicators that reflect the condition of each patient in other immunological neurological diseases such as MS. Th17 cells also regulate the development of various autoimmune diseases, including MS. Thus, the restoration of weakened immune regulatory functions may be a true disease-modifying treatment. So far, steroids and immunosuppressants have been the mainstream for autoimmune diseases, but the problem is that this kills not only pathogenic T cells, but also lymphocytes, which are necessary for the body. From this understanding of the immune regulation of MS, we can expect the development of therapeutic strategies that target only pathogenic immune cells.

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Is Asian type MS an MS phenotype, an NMO spectrum disorder, or a MOG-IgG related disease?

Cited by 8 publications

References 39 publications

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent

Optic neuritis in Asian type opticospinal multiple sclerosis (OSMS-ON) in a non-Asian population: A functional-structural paradox

Unraveling the Immunopathogenesis of Multiple Sclerosis: The Dynamic Dance of Plasmablasts and Pathogenic T Cells

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