Optic neuritis in Asian type opticospinal multiple sclerosis (OSMS-ON) in a non-Asian population: A functional-structural paradox

Meneguette, Nathalie Stéphanie; Almeida, Kelly Mayane Figueiredo Ramos; Figueiredo, Marco Túlio José de Oliveira; Araújo, Ana Carolina Ribeiro de Araújo e; Alvarenga, Marcos Papais; Vasconcelos, Cláudia Cristina Ferreira; Nascimento, Anna Christiany Brandão; Colombini, Giovanni Nicola Umberto Italiano; Petzold, Axel; Alvarenga, Regina Maria Papais

doi:10.1016/j.msard.2021.103260

Cited by 3 publications

(1 citation statement)

References 36 publications

(54 reference statements)

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“…UNKNOWN AETIOLOGY 1 0.39 Subgroups of optic neuritis from Delphi round #1-#12 not yet included at level 2 Amiodarone 138 ANCA+ 139,140 Anti-TNF-α 141,142 Associated with malformations Syndromic AZOOR [143][144][145] Behçet's 146 Cell mediated 147,148 GFAP autoantibody [149][150][151] GQ1b autoantibody [152][153][154] Giant cell arteritis 155 IgG4 156 MDEM 157 NMDA autoantibody [158][159][160] Optico-spinal optic neuritis [161][162][163] Paranasal sinusitis [164][165][166][167][168] Appendix Figure 17: Interim Classification for Delphi Rounds 12-22. This figure was then further developed incorporating the feed-back from the experts.…”

Section: A2 Methodsmentioning

confidence: 99%

Diagnosis and classification of optic neuritis

Petzold

Fraser²,

Abegg³

et al. 2022

The Lancet Neurology

113

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Section: A2 Methodsmentioning

confidence: 99%

Diagnosis and classification of optic neuritis

Petzold

Fraser²,

Abegg³

et al. 2022

The Lancet Neurology

113

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Clinical review of retinotopy

et al. 2021

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Two observations made 29 years apart are the cornerstones of this review on the contributions of Dr Gordon T. Plant to understanding pathology affecting the optic nerve. The first observation laid the anatomical basis in 1990 for the interpretation of optical coherence tomography (OCT) findings in 2009. Retinal OCT offers clinicians detailed in vivo structural imaging of individual retinal layers. This has led to novel observations which were impossible to make using ophthalmoscopy. The technique also helps to re-introduce the anatomically grounded concept of retinotopy to clinical practise. This review employs illustrations of the anatomical basis for retinotopy through detailed translational histological studies and multimodal brain-eye imaging studies. The paths of the prelaminar and postlaminar axons forming the optic nerve and their postsynaptic path from the dorsal lateral geniculate nucleus to the primary visual cortex in humans are described. With the mapped neuroanatomy in mind we use OCT-MRI pairings to discuss the patterns of neurodegeneration in eye and brain that are a consequence of the hard wired retinotopy: anterograde and retrograde axonal degeneration which can, within the visual system, propagate trans-synaptically. The technical advances of OCT and MRI for the first time enable us to trace axonal degeneration through the entire visual system at spectacular resolution. In conclusion, the neuroanatomical insights provided by the combination of OCT and MRI allows us to separate incidental findings from sinister pathology and provides new opportunities to tailor and monitor novel neuroprotective strategies.

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Retinal inter-eye difference and atrophy progression in multiple sclerosis diagnostics

Bijvank

Uitdehaag

Petzold

2021

J Neurol Neurosurg Psychiatry

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BackgroundThe visual system could be included in the diagnostic criteria for multiple sclerosis (MS) to demonstrate dissemination in space (DIS) and dissemination in time (DIT).ObjectiveTo investigate the diagnostic value of retinal asymmetry in MS.MethodsA prospective, longitudinal study in individuals with MS (n=151) and healthy controls (n=27). Optical coherence tomography (OCT) was performed at 0, 2 and 4 years. Macular ganglion cell and inner plexiform layer (mGCIPL) thickness was determined as well as measures for retinal asymmetry: the inter-eye percentage difference (IEPD) and inter-eye absolute difference (IEAD). Receiver operator characteristics curves were plotted and the area under the curve (AUC) was calculated for group comparisons of the mGCIPL, IEPD, IEAD and atrophy rates.ResultsThe diagnostic accuracy of both the IEPD and IEAD for differentiating bilateral and unilateral MS optic neuritis was high and stable over time (AUCs 0.88–0.93). The IEPD slightly outperformed the IEAD. Atrophy rates showed low discriminatory abilities for differentiating MS from controls (AUC 0.49–0.58).ConclusionThe inter-eye differences of the mGCIPL have value for demonstration of DIS but in individuals with longstanding MS not for DIT. This may be considered as a test to detect DIS in future diagnostic criteria. Validation in a large prospective study in people presenting with symptoms suggestive of MS is required.

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Optic neuritis in Asian type opticospinal multiple sclerosis (OSMS-ON) in a non-Asian population: A functional-structural paradox

Cited by 3 publications

References 36 publications

Diagnosis and classification of optic neuritis

Diagnosis and classification of optic neuritis

Clinical review of retinotopy

Retinal inter-eye difference and atrophy progression in multiple sclerosis diagnostics

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