Is arthrocentesis plus hyaluronic acid superior to arthrocentesis alone in the treatment of disc displacement without reduction in patients with bruxism?

Combined Platelet-Rich Plasma and Hyaluronic Acid can Reduce Pain in Patients Undergoing Arthrocentesis for Temporomandibular Joint Osteoarthritis

“…This study was the first to investigate the clinical efficacy of arthrocentesis with subsequent intra-articular injection of PRP, HA, and PRP+HA in managing patients with TMJ-OA complaints, based on our literature review. 1,2,[5][6][7][8][9]13,16,21 Our findings showed that combined PRP and HA can reduce pain in patients undergoing arthrocentesis for TMJ-OA.…”

“…24 Due to this reason, incorporating a control or placebo group in the present study did not seem ethical and logical. 2,7,21 HA is a natural glycosaminoglycan which is normally produced by synovial cells and found in the synovial fluid. This acid is an essential component of each joint, including the TMJ.…”

“…12 However, the efficacy of PRP or HA injection in arthrocentesis compared to arthrocentesis alone (without any PRP or HA injection) has been established through previously conducted studies. 2,7,21 Studies by Kilic et al, Hegab et al, and Goaito et al explained that intrajoint injection of PRP or HA following arthrocentesis should be favored over arthrocentesis alone. [5][6][7][8][9] Therefore, incorporating a nontreatment control group that would only undergo arthrocentesis would be nonlogical in our study.…”

“…Since the efficacy of PRP or HA injection in arthrocentesis compared to arthrocentesis alone (without any PRP or HA injection) has been established through previously conducted studies, 2,7,21 it was deemed nonethical and illogical to incorporate a nontreatment control group that would only undergo arthrocentesis.…”

Current Clinical Research Directions on Temporomandibular Joint Intra-Articular Injections: A Mapping Review

“…There is a steady upward trend in the number of primary studies on HA published in subsequent years. The primacy of HA from 2021 seems to be threatened by centrifuged blood products, but this group of substances is heterogeneous and cannot be compared to HA in terms of effectiveness as a whole [18,19,22,25,38,43,49,51,54,[58][59][60]63,68,70,71,74,75,78,80,80,82,86,88,89,[91][92][93]95,[98][99][100][101][102]105,106,110,[113][114][115][116][117]120,121,124,126,127,129,130,…”