Current Clinical Research Directions on Temporomandibular Joint Intra-Articular Injections: A Mapping Review

Abstract

This mapping review aims to identify and discuss current research directions on intracavitary temporomandibular joints (TMJs) injections. The inclusion criteria allowed studies published in the last full six years, based on patients diagnosed with temporomandibular joint disorders (TMDs), treated by TMJ intra-articular injections. Medical databases covered by the Association for Computing Machinery, Bielefeld Academic Search Engine, PubMed, and Elsevier Scopus engines were searched. The results were visualized with tables, charts, and diagrams. Of the 2712 records identified following the selection process, 152 reports were qualified for review. From January 2017, viscosupplementation with hyaluronic acid (HA) was the best-documented injectable administered into TMJ cavities. However, a significant growing trend was observed in the number of primary studies on centrifuged blood preparations administrations that surpassed the previously leading HA from 2021.

Temporomandibular Joint (TMJ) Replacement Affects Quality of Life: A Systematic Review and Synthesis of Clinical Trials

“…Albeit degenerative disease can reach a severity that exceeds the possibilities of conservative and minimally invasive treatment. Then, TMJ replacement should be considered as a real alternative to more conservative pain relief approaches [6,[24][25][26][27][28][29][30][31][32].…”

Efficacy of Injectable Platelet-Rich Fibrin (I-PRF) in Managing Temporomandibular Joint Pain: A Prospective Clinical Study

“…However, these approaches may have limitations in addressing the diverse underlying causes and providing sustained relief. In recent years, regenerative medicine has gained attention as a potential avenue for managing TMJ disorders [ 5 ]. Injectable platelet-rich fibrin (I-PRF), a form of autologous platelet concentrate, has demonstrated promising results in promoting tissue regeneration and modulating inflammatory processes [ 6 ].…”

Intra-Articular Local Anesthetics in Temporomandibular Disorders: A Systematic Review and Meta-Analysis

“…An alternative to systemic analgesic pharmacotherapy is the local administration of drugs. The professional literature indicates the possibility of performing nearby nerve blocks, intra-articular administration of anti-inflammatory drugs (corticosteroids and nonsteroidal anti-inflammatory drugs), analgesics (opioids), or local anesthetics [ 17 , 18 , 19 , 20 , 21 , 22 ].…”

“…According to the latest reports, cytotoxicity of bupivacaine in intra-articular injections is suspected, and there have been many reports of chondrolysis after shoulder arthroscopy in which intra-articular injections of anesthetics were used [ 25 , 27 ]. Injection of local anesthetics into the temporomandibular joint cavities is not commonly performed [ 21 , 28 ]. The growing number of scientific publications on this topic allows for a first cross-sectional evaluation and encourages a critical assessment of the effectiveness of the discussed therapy [ 21 , 28 ].…”

“…Injection of local anesthetics into the temporomandibular joint cavities is not commonly performed [ 21 , 28 ]. The growing number of scientific publications on this topic allows for a first cross-sectional evaluation and encourages a critical assessment of the effectiveness of the discussed therapy [ 21 , 28 ].…”