Is Aquatic Physical Therapy a Feasible Treatment for Musculoskeletal Dysfunction of Sickle Cell Disease Patients?

Zanoni, Camila Tatiana; Galvão, Fábio; Cliquet, Alberto

doi:10.4172/2157-7595.1000216

J Yoga Phys Ther

2015

DOI: 10.4172/2157-7595.1000216

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Is Aquatic Physical Therapy a Feasible Treatment for Musculoskeletal Dysfunction of Sickle Cell Disease Patients?

Camila Tatiana Zanoni¹,

Fábio Galvão²,

Alberto Cliquet³

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2018

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“…Another study performed in patients with SCD who received gene therapy with the use of lentiviral gene addition of an antisickling β-globin variant, showed that normal blood cell counts were attained after the transduced stem cells were engrafted. While adverse events related to the BB305-transduced cells were not observed, and the pattern of vector integration remained polyclonal without clonal dominance, insertional oncogenesis was reported in clinical gene-transfer studies with gamma retroviral vectors [94,95].…”

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confidence: 96%

Sickle Cell Anaemia- A Synopsis of the Inherited Ailment

Chatterjee¹,

Agrawal²,

Adapa³

et al. 2018

Arch Med

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Sickle Cell Anaemia (SCA) is one of the most prevalent monogenic disorders. The formation of polymerised haemoglobin leading to erythrocyte rigidity and appearance of characteristic sickle-shaped Red blood Cells (RBCs) resulting in vascular occlusion and haemolysis is central to the molecular pathogenesis of the disease. A major drawback of the disease in children is the development of cerebrovascular disease, hypoxia, and neuro-cognitive impairment. The recurrent episodes of vascular occlusion and inflammation of the vessels lead to progressive organ damage which becomes apparent with age. In addition to hydroxyurea and butyrate treatments, novel methods such as gene therapy and others to prevent complications from SCA are being evaluated. This article reviews the diagnostic approaches, therapies and advancements in SCA treatment with particular emphasis on the future perspective of research towards a cure for SCA.

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mentioning

confidence: 96%

Sickle Cell Anaemia- A Synopsis of the Inherited Ailment

Chatterjee¹,

Agrawal²,

Adapa³

et al. 2018

Arch Med

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Is Aquatic Physical Therapy a Feasible Treatment for Musculoskeletal Dysfunction of Sickle Cell Disease Patients?

Cited by 1 publication

References 19 publications

Sickle Cell Anaemia- A Synopsis of the Inherited Ailment

Sickle Cell Anaemia- A Synopsis of the Inherited Ailment

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