Is Anti-Müllerian Hormone Associated with IVF Outcomes in Young Patients with Diminished Ovarian Reserve?

Pereira, Nigel; Setton, Robert; Petrini, Allison C.; Lekovich, Jovana P.; Elias, Rony T.; Spandorfer, Steven D.

doi:10.2217/whe.15.102

Cited by 19 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As mentioned above, data on the qualitative importance of AMH for oocytes are unclear. AMH levels have been shown to correlate with the number of oocytes retrieved during gonadotrophin stimulation; however, studies on the correlation of AMH with the number of clinically successful pregnancies are often contradictory, and AMH levels do not correlate with the number of live births . These findings question the ability of serum AMH as a predictor of the course of pregnancy and/or spontaneous abortion at an early stage .…”

Section: Introductionmentioning

confidence: 98%

“…AMH levels have been shown to correlate with the number of oocytes retrieved during gonadotrophin stimulation; however, studies on the correlation of AMH with the number of clinically successful pregnancies are often contradictory, 10,11 and AMH levels do not correlate with the number of live births. 13,14 These findings question the ability of serum AMH as a predictor of the course of pregnancy and/or spontaneous abortion at an early stage. 8,9,11 The aim of the present study was therefore to study the prognostic value of AMH serum levels as a marker of early abortion among women younger than 35 years in the first trimester of spontaneous pregnancy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy

Kostrzewa

Żyła

Horzelski

et al. 2020

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Objective To assess anti‐Müllerian hormone (AMH) levels as a marker of early abortion in the first trimester among women younger than 35 years. Methods Prospective study of women aged 18–34 years with a spontaneous pregnancy at less than 12.6 gestational weeks in Łódź, Poland, between January 2017 and November 2018. Cases of anembryonic abortion and assisted conception were excluded. Blood samples were collected and assayed for serum AMH levels. Data were compared between women with an embryo with no cardiac activity by ultrasound (n=30) and those with a normal embryo (n=33) by using Statistica12 software. Results The 10th and 90th percentiles of serum AMH concentration among control women were used to identify a reference AMH range (1.1–4.5 ng/mL). Risk of pregnancy loss in the first trimester was found to be higher for both low AMH (<1.1 ng/mL; relative risk [RR], 3.66; 95% confidence interval [CI], 2.1–6.4; P<0.001) and high AMH (>4.5 ng/mL; RR, 3.0; 95% CI, 1.61–5.59; P<0.001). Conclusions Both very low and very high AMH concentrations were found to significantly increase the risk of abortion in the first trimester of pregnancy. Serum AMH might be a valuable marker to predict the risk of early abortion.

show abstract

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy

Kostrzewa

Żyła

Horzelski

et al. 2020

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…In young patients with low AMH levels who have good quality embryos, AMH is not associated with clinical pregnancy, spontaneous miscarriage, or live birth rates [16].…”

Section: Discussionmentioning

confidence: 92%

Live birth rate after IVF/ICSI in women with low and extremely low AMH: an age-matched controlled study

Zaghloul

Amin

Mansour

et al. 2020

Middle East Fertil Soc J

View full text Add to dashboard Cite

Background: An age-matched controlled study, to assess the outcome of IVF/ICSI in low and extremely low AMH levels in different age groups by comparing the live birth rate Materials and methods: An age-matched controlled study was done at the Egyptian IVF center, Cairo, Egypt, including 306 infertile women with low AMH levels undergoing IVF/ICSI and an age-matched number of women with normal AMH. The live birth rate in the different age groups according to the AMH level was compared. Results: There was no significant difference between LBR in the extremely low AMH arm (11.43%) and low AMH (16.4%) (P = 0.24). The LBR was 30.4% in women with normal AMH as compared to 14.7% in all women with AMH below 1 pg/ml (P = 0.002). The LBR was significantly higher in women below the age of 35 years and women of 35-40 years with normal AMH (33.2% and 31.7%) as compared to LBR in the corresponding age groups with low AMH (18.6% and 13.3%). Conclusions: There was no difference in the outcome of IVF between patients with low and extremely low AMH levels. Women with normal AMH level resulted in a higher pregnancy rate as compared to women with low AMH level in the same age group. Age is important in determining prognosis of IVF in patients with low levels of AMH.

show abstract

“…This finding is of particular importance to women who require ART after salpingectomy. Reduced ovarian reserve, as reflected by lower AMH serum concentrations, correlate with a lower oocyte yield after controlled ovarian hyperstimulation . Studies report a strong correlation between the number of oocytes retrieved per cycle and live birth …”

Section: Discussionmentioning

confidence: 99%

The effect of laparoscopic salpingectomy for ectopic pregnancy on ovarian reserve

Rodgers

Carter

Reid³

et al. 2020

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

Background: Salpingectomy may damage ovarian reserve by direct vascular interruption to the ovary or thermal vascular injury from electrosurgery. It is plausible that this risk may increase in the context of salpingectomy conducted for ectopic pregnancy due to the distension of the fallopian tube and vascular changes associated with pregnancy.Aim: To report anti-Müllerian hormone (AMH) concentrations before and after laparoscopic salpingectomy for ectopic pregnancy as an indicator of change in ovarian reserve. Materials and Methods:Women aged 18-44 years scheduled for salpingectomy for tubal ectopic pregnancy were prospectively recruited. Serum AMH concentrations were measured immediately prior to surgery, then repeated four months post-operatively. In all cases, salpingectomy was conducted laparoscopically using bipolar electrosurgery and mechanical scissors. A group of women scheduled for uterine curettage for first trimester miscarriage was recruited to ensure any observed change in AMH concentration in the women undergoing salpingectomy was secondary to surgery, rather than an effect of pregnancy.Results: Paired pre-and post-operative serum AMH concentrations were obtained from 32 women with tubal ectopic pregnancy. The mean age of the women was 33.6 ± 4.6 years. There was no significant difference in the median pre-and postoperative AMH concentrations (13.00 pmol/L (range 5-67 pmol/L) vs 15.25 pmol/L (range 3-96 pmol/L), P = 0.575). Median AMH concentrations also remained stable in women experiencing a first trimester miscarriage (10.40 pmol/L (range 3.9-37.8 pmol/L) vs 13.67 pmol/L (range 2.8-30.5 pmol/L), P = 0.185). Conclusion:Laparoscopic salpingectomy using electrosurgery and mechanical scissors does not damage ovarian reserve. AMH concentrations do not fluctuate from baseline in the first trimester of pregnancy. K E Y W O R D Santi-Müllerian hormone, ectopic pregnancy, ovarian reserve, salpingectomy

show abstract

Is Anti-Müllerian Hormone Associated with IVF Outcomes in Young Patients with Diminished Ovarian Reserve?

Cited by 19 publications

References 32 publications

Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy

Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy

Live birth rate after IVF/ICSI in women with low and extremely low AMH: an age-matched controlled study

The effect of laparoscopic salpingectomy for ectopic pregnancy on ovarian reserve

Contact Info

Product

Resources

About