Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy

Kostrzewa, Marta; Żyła, Monika; Horzelski, Wojciech; Kaczmarek, Beata; Szyłło, Krzysztof; Grzesiak, Mariusz

doi:10.1002/ijgo.13104

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…Similar to our study, Kostrzewa et al [ 27 ] reported that in patients younger than 35 years with a spontaneous pregnancy, both low (< 1.1 ng/mL) and high (> 4.5 ng/mL) AMH concentrations significantly increased the risk of pregnancy loss in the first trimester. Gleicher et al [ 28 ] built logistic regression models to predict IVF outcomes.…”

Section: Discussionsupporting

confidence: 91%

“…The rates of pregnancy loss are higher among women with PCOS than among women without the syndrome [ 32 , 33 ]. The abovementioned studies also showed similar pregnancy outcomes among women without PCOS but with high AMH levels [ 27 – 29 ]. Nilsson et al [ 34 ] reported that AMH suppresses growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) expression.…”

Section: Discussionmentioning

confidence: 86%

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Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle

Liu

Han

Wang

et al. 2022

BMC Pregnancy Childbirth

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Background Anti-Müllerian hormone (AMH) is used as a biomarker to estimate ovarian reserve. The relationship between AMH and early miscarriage of in vitro fertilization (IVF) is still inconclusive. This study aimed to explore whether serum AMH levels are associated with early miscarriage rates after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with fresh embryo transfer (ET). Methods This retrospective cohort study included 2246 patients undergoing their first oocyte retrievals for IVF/ICSI with fresh embryos transferred to Tianjin Central Hospital of Gynecology Obstetrics between May 2018 and March 2020. The serum AMH levels of the patients were measured within 12 months before the IVF/ICSI cycles. All women were divided into a low-AMH group, medium-AMH group and high-AMH group. Binary logistic regression was applied to confirm whether the serum AMH level was associated with the risk of early miscarriage independent of potential confounders, such as age, body mass index (BMI), duration of infertility, main diagnosis, history of internal medicine diseases, number of oocytes retrieved and high-quality embryo rate. Results The early miscarriage rate was significantly lower in the medium-AMH group than in either the low-AMH or high-AMH group among young (< 35 years) women (P = 0.015). In women above 35 years of age, the early miscarriage rates in the three AMH groups were not significantly different. Young women with high serum AMH levels had a significantly higher risk of early miscarriage regardless of age or other potential confounders (adjusted odds ratio (OR) 2.382, 95% confidence interval (CI) 1.246 to 4.553, P = 0.009). The results remained similar after restricting the analysis to women without polycystic ovary syndrome (PCOS). Conclusions With a high AMH level, young women had a higher risk of early miscarriage than women with a medium AMH level in their first IVF/ICSI treatment. In young women, serum AMH levels were independently associated with the risk of early miscarriage after IVF-ET treatment. Serum AMH levels might be a valuable marker to estimate the risk of early miscarriage. It is worth noting to the clinical value of AMH.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 86%

Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle

Liu

Han

Wang

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…In contrast, the adjusted relative risk of miscarriage corresponding to AMH levels <1.0, 1.0–3.5 versus >3.5 ng/mL was 1.13 (0.74–1.72) versus Ref versus 1.13 (0.82–1.56) in another prospective study 22 . Kostrzewa et al reported RR for miscarriage corresponding AMH levels <1.1 versus 1.1–4.5 versus >4.5 ng/mL was 3.66 (2.1–6.4, p < 0.001) versus Ref versus 3.0 (1.61–5.59, p < 0.001), although the study recruited only 66 women 19 . Based on the conflicting results and inconsistent study designs, the systematic review concluded that clinical recommendations could not be offered 18 …”

Section: Resultsmentioning

confidence: 97%

“…22 Kostrzewa et al reported RR for miscarriage corresponding AMH levels <1.1 versus 1.1-4.5 versus >4.5 ng/mL was 3.66 (2.1-6.4, p < 0.001) versus Ref versus 3.0 (1.61-5.59, p < 0.001), although the study recruited only 66 women. 19 Based on the conflicting results and inconsistent study designs, the systematic review concluded that clinical recommendations could not be offered. 18 CQ2.…”

Section: Resultsmentioning

confidence: 99%

Anti‐Müllerian hormone for screening, diagnosis, evaluation, and prediction: A systematic review and expert opinions

Iwase,

Asada,

Sugishita

et al. 2023

J of Obstet and Gynaecol

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AimTo present evidence‐based recommendations for anti‐Müllerian hormone (AMH) measurement as an ovarian reserve test.MethodsA systematic literature search for the clinical utility of AMH was conducted in PubMed from its inception to August 2022 to identify studies, including meta‐analyses, reviews, randomized controlled trials, and clinical trials, followed by an additional systematic search using keywords. Based on this evidence, an expert panel developed clinical questions (CQs).ResultsA total of 1895 studies were identified and 95 articles were included to establish expert opinions subdivided into general population, infertility treatment, primary ovarian insufficiency, polycystic ovary syndrome, surgery, and oncofertility. We developed 13 CQs and 1 future research question with levels of evidence and recommendations.ConclusionThe findings of the current systematic review covered the clinical utility of AMH including its screening, diagnosis, evaluation, and prediction. Although some clinical implications of AMH remain debatable, these expert opinions may help promote a better understanding of AMH and establish its clinical significance.

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“…Recently, research found that high levels of serum AMH had a significantly higher risk of miscarriage in women with or without PCOS [ 46 ]. Similarly, an increased rate of miscarriage has been reported in women with high or low AMH levels [ 47 ]. High serum AMH levels were also associated with an increased risk of preterm delivery in women with PCOS [ 48 ].…”

Section: Discussionmentioning

confidence: 95%

Association of the Cumulative Live Birth Rate with the Factors in Assisted Reproductive Technology: A Retrospective Study of 16,583 Women

Wang

Zhang

et al. 2023

JCM

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The cumulative live birth rate (CLBR) can better reflect the overall treatment effect by successive treatments, and continuous rather than categorical variables as exposure variables can increase the statistical power in detecting the potential correlation. Therefore, the dose–response relationships might find an optimal dose for the better CLBR, offering evidence-based references for clinicians. To determine the dose–response relationships of the factors and the optimal ranges of the factors in assisted reproductive technology (ART) associated with a higher CLBR, this study retrospectively analyzed 16,583 patients undergoing the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) from January 2017 to January 2019. Our study demonstrated the optimal ranges of age with a higher CLBR were under 32.10 years. We estimated the CLBR tends to increase with increased levels of AMH at AMH levels below 1.482 ng/mL, and the CLBR reaches a slightly high level at AMH levels in the range from 2.58–4.18 ng/mL. The optimal ranges of basal FSH with a higher CLBR were less than 9.13 IU. When the number of cryopreserved embryos was above 1.055 and the number of total transferred embryos was 2, the CLBR was significantly higher. In conclusion, there is a non-linear dose–response relationship between the CLBR with age, AMH, basal FSH, and the number of cryopreserved embryos and total transferred embryos. We proposed the optimal ranges of the five factors that were correlated with a higher CLBR in the first oocyte retrieval cycle, which may help consultation at IVF clinics.

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Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy

Cited by 8 publications

References 25 publications

Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle

Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle

Anti‐Müllerian hormone for screening, diagnosis, evaluation, and prediction: A systematic review and expert opinions

Association of the Cumulative Live Birth Rate with the Factors in Assisted Reproductive Technology: A Retrospective Study of 16,583 Women

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