Is an oral disintegrating tablets a formulation that is easy to ingest for patients experiencing difficulty with eating and swallowing?

Umaki, Yoshifumi; Nozaki, Sonoko; Sugishita, Shuhei; Shiimoto, Kumiko; Hashiguchi, Shuji; Inui, Tomoyuki; Adachi, Kazutaka

doi:10.5692/clinicalneurol.49.90

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…This is mainly because of their advantages for patients with poor swallowability and because they do not need to be taken with water. 5,6) However, if ODTs containing bitter medicines are kept in the mouth with even a small volume of saliva for few seconds, the concentration of dissolved drug in the oral cavity may exceed the bitterness threshold of the medicine. 7,8) Recently, ODTs have been developed containing small functional particles with novel taste-masking properties or photostability.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Novel Functional Drug Particles Embedded in a Gelling–Swelling Layer (PEGS) for Taste Masking and Subsequent Rapid Drug Release

Ijitsu

Hoashi

Hori

et al. 2021

CHEMICAL & PHARMACEUTICAL BULLETIN

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The purpose of this research was to develop novel functional drug particles embedded in a gelling-swelling layer (PEGS) which are capable of achieving both taste-masking of unpalatable drugs and rapid drug elution. The functional particles had a three-layer structure consisting of a core drug layer, a gelling-swelling layer and an outer water-penetration control layer containing a water-insoluble polymer. The concept of formulation design was as follows: when water reaches the gelling-swelling layer, pulverized fine gelling-swelling particles gellate and swell from water absorption to form a rigid layer, thereby preventing drug release. After a defined lag time, the increased volume of the gelling-swelling layer breaks down the outer water-penetration control layer, leading to rapid drug release.In order to adapt this system for use in orally disintegrating tablets, PEGS were prepared at a size of about 250 μm using a fine particle-coating method. Ambroxol hydrochloride was used as a model drug for bitterness and the effects of different gelling-swelling agents and water-insoluble polymers on drug release characteristics from PEGS were examined. In in vitro dissolution tests, it was shown that the drug dissolution rate from PEGS could be suppressed to about 5% after 2 minutes and increased to more than 85% after 30 minutes by adjusting the composition and thickness of the outer layer. The PEGS expanded about 1.5-fold and the outer layer was ruptured after 5 minutes in water.

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Section: Introductionmentioning

confidence: 99%

Preparation of Novel Functional Drug Particles Embedded in a Gelling–Swelling Layer (PEGS) for Taste Masking and Subsequent Rapid Drug Release

Ijitsu

Hoashi

Hori

et al. 2021

CHEMICAL & PHARMACEUTICAL BULLETIN

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Preparation of Solifenacin Succinate Functional Particles Embedded in a Gelling–Swelling Layer (PEGS) and Their Formulation in Orally Disintegrating Tablets

Ijitsu

Hoashi

Hori

et al. 2021

CHEMICAL & PHARMACEUTICAL BULLETIN

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Quality Evaluation for Pharmaceutical Products and Medical Supplies: Proper Use

Miyamoto

2014

YAKUGAKU ZASSHI

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In the proper use of medicine, the quality of medical supplies is an important factor. Use of generic products not only reduces drug costs for the patient, but also oŠers substantial advantages for governments in reducing medical expenses. When evaluation of the quality of generic products is centered on tablets, products with qualities that are unstable over time may be encountered. Some dosage forms require suitable pharmaceutical tests, processes, and apparatuses, such as those for evaluating orally disintegrating tablets or cutaneous preparations. For example, although simple test equipment has been proposed for patches, a uniˆed method is required. The pharmacist plays an important role in choosing high-quality generic products; however, a substantial amount of information needs to be made available to the public in order to achieve that goal.Key words-evaluation of pharmaceutical products; dosage form; products quality test; generic product; patch

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Is an oral disintegrating tablets a formulation that is easy to ingest for patients experiencing difficulty with eating and swallowing?

Cited by 4 publications

References 4 publications

Preparation of Novel Functional Drug Particles Embedded in a Gelling–Swelling Layer (PEGS) for Taste Masking and Subsequent Rapid Drug Release

Preparation of Novel Functional Drug Particles Embedded in a Gelling–Swelling Layer (PEGS) for Taste Masking and Subsequent Rapid Drug Release

Preparation of Solifenacin Succinate Functional Particles Embedded in a Gelling–Swelling Layer (PEGS) and Their Formulation in Orally Disintegrating Tablets

Quality Evaluation for Pharmaceutical Products and Medical Supplies: Proper Use

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