Preparation of Solifenacin Succinate Functional Particles Embedded in a Gelling–Swelling Layer (PEGS) and Their Formulation in Orally Disintegrating Tablets

Ijitsu, Shin; Hoashi, Yohei; Hori, Koji; Okimoto, Kazuto; Kai, Toshiya; Yoshida, Miyako; Uchida, Takahiro

doi:10.1248/cpb.c20-01009

Search citation statements

Order By: Relevance

Paper Sections

Select...

Concentration-intensity Taste Masking1

Insoluble Materials Coating1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, due to the complexity of such taste-masking granules, the conventional wet granulation and tableting methods are not applicable for high standards of excipients selection and process conditions in the preparation of molding. To solve that, Ijitsu et al used spherical mannitol as the excipient of Solifenacin succinate ODT and the semidirect compression without granulation, promoting the use of this new coating on ODT …”

Section: Concentration-intensity Taste Maskingmentioning

confidence: 99%

See 1 more Smart Citation

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Xie

et al. 2022

Mol. Pharmaceutics

View full text Add to dashboard Cite

Orodispersible dosage forms, characterized as quick dissolving and swallowing without water, have recently gained great attention from the pharmaceutical industry, as these forms can satisfy the needs of children, the elderly, and patients suffering from mental illnesses. However, poor taste by thorough exposure of the drugs’ dissolution in the oral cavity hinders the effectiveness of the orodispersible dosage forms. To bridge this gap, we put forward three taste-masking strategies with respect to the intensity of time, concentration, and perception. We further investigated the raw material processing, the composition of auxiliary material, formulation techniques, and process control in each strategy and drew conclusions about their effects on taste masking.

show abstract

Section: Concentration-intensity Taste Maskingmentioning

confidence: 99%

“…To solve that, Ijitsu et al used spherical mannitol as the excipient of Solifenacin succinate ODT and the semidirect compression without granulation, promoting the use of this new coating on ODT. 33 3.1.3. Salting-Out System Coating.…”

Section: Insoluble Materials Coatingmentioning

confidence: 99%

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Xie

et al. 2022

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

Preparation of Solifenacin Succinate Functional Particles Embedded in a Gelling–Swelling Layer (PEGS) and Their Formulation in Orally Disintegrating Tablets

Cited by 1 publication

References 32 publications

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Contact Info

Product

Resources

About