Is Africa the origin of major Haitian Staphylococcus aureus lineages?

Schaumburg, Frieder; Gast, Birgit; Sannon, Herriot; Mellmann, Alexander; Becker, Karsten

doi:10.1016/j.ijid.2015.02.012

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Consequently, detection of high rates of PVL-positive ST8-MSSA in Trinidad and Tobago gave reason to speculate about a Caribbean origin of the USA300 lineage ( 29 ). When high rates of PVL-positive ST152-MSSA were detected in Haiti, their origin was linked with sub-Saharan Africa (SSA) because many people from the Caribbean have African ancestry ( 30 , 31 ) and PVL is known to be present in SSA in very high rates ( 6 , 7 , 32 ). Like ST152, ST8 is a widespread clone in SSA.…”

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confidence: 99%

Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8

Strauß

Stegger

Akpaka

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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SignificanceUSA300 is a hypervirulent, community-acquired, multidrug-resistant Staphylococcus aureus clone that started to spread in the United States around 17 years ago. Many studies detected it also in South America, Europe, and the Asia-Pacific region. In this study, we show that USA300 is also circulating in sub-Saharan Africa. Locating the temporal and spatial origin of clonal lineages is important with respect to epidemiology and molecular evolution of pathogens. We show that USA300 evolved from a less virulent and less resistant ancestor circulating in Central Europe around 160 years ago. Constant surveillance of pathogen transmission routes is vital to prevent and control potential outbreaks. Whole genome sequencing proved to be a useful tool for epidemiological surveillance.

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mentioning

confidence: 99%

Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8

Strauß

Stegger

Akpaka

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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132

181

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“…In Haiti, in one study from 10 S. aureus clinical isolates (skin and soft tissues infections and empyema) ST672 was identified in one isolate. This strain was categorized as CC672 and was from MSSA penicillin susceptible and PVL- positive ( Schaumburg et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Surveillance of osteoarticular infections caused by Staphylococcus aureus in a paediatric hospital in Mexico City

Aguilar-Gómez

Mérida-Vieyra

Isunza-Alonso

et al. 2022

Front. Cell. Infect. Microbiol.

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Staphylococcus aureus is the main aetiologic agent of osteoarticular infections (OAIs) in paediatric patients. The aim of this prospective unicenter study was to describe the phenotypic and genotypic characteristics of S. aureus isolates obtained from OAIs in paediatric patients admitted to tertiary care hospital. Through a surveillance program called OsteoCode, a multidisciplinary team was created and we identified 27 patients with OAIs caused by S. aureus from 2019 to 2021. The susceptibility profile, virulence factors, biofilm formation, pulsed-field gel electrophoresis (PFGE), clonal complex (CC) and sequence type (ST) were determined. In addition, the clinical characteristics and evolution of the patients presented six months after the diagnosis of OAIs were described. Ninety-two percent of the isolates were methicillin-sensitive S. aureus (MSSA). In methicillin-resistant S. aureus (MRSA), SCCmec-II and SCCmec-V were detected. The pvl gene was only observed in MSSA (18.5%) and was associated with highest fever (p=0.015), multiple localization (p=0.017), and soft tissue sites of infection beyond the bone (pyomyositis, pulmonary abscess) (p=0.017). Biofilm formation was detected in 55.6% of isolates. The most common CC were CC5 and CC30 which represent the most common linages for bone and joint infections worldwide. The isolates were distributed in different STs, and ST672 was predominant. MRSA were associated with a longer duration of intravenous treatment and a prolonged hospital stay (p=0.023). Recurrent infection occurred in five children and orthopaedic complications in 33.3% of patients. This is the first study that reflects the epidemiology of S. aureus in OAIs in paediatric patients in Mexico; a clear predominance of MSSA distributed in different STs was observed. Our findings highlight that a multidisciplinary team is required for the diagnosis and treatment of OAIs.

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Molecular epidemiology of Staphylococcus aureus from Lambaréné, Gabon

Okuda

Toepfner

Alabi

et al. 2016

Eur J Clin Microbiol Infect Dis

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While there is an abundance of data on the epidemiology and molecular typing of Staphylococcus aureus, especially those carrying Panton-Valentine leucocidin (PVL) genes or mecA from Western Europe, Northern America and Australia, comparably few studies target African strains. In this study, we characterised genes associated with virulence and resistance, as well the phylogenetic background of S. aureus from healthy carriers and outpatients in Gabon. In total, 103 isolates from 96 study participants were characterised. Seventy-nine isolates originated from throat swabs and 24 isolates from skin lesions. Three isolates carried mecA, although only one, belonging to CC8-MRSA-IV [PVL+] 'USA300', was found to be phenotypically oxacillin-resistant; two CC88-MRSA-IV isolates appeared to be oxacillin-susceptible. PVL genes were common, with a total of 44 isolates (43 %) found to be PVL-positive. CC15-MSSA [PVL+] (n = 29) and CC152-MSSA [PVL+] (n = 9) were the predominant clones among the PVL-positive isolates. Among PVL-negative isolates, CC5-MSSA (n = 12), CC101-MSSA (n = 10) and CC15 (n = 9) were the most frequent. A hitherto undescribed multilocus sequence type of S. schweitzeri was detected twice in unrelated patients. The data emphasise a need for further studies on the role of PVL in African populations and the clinical significance of S. schweitzeri.

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Is Africa the origin of major Haitian Staphylococcus aureus lineages?

Cited by 3 publications

References 9 publications

Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8

Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8

Surveillance of osteoarticular infections caused by Staphylococcus aureus in a paediatric hospital in Mexico City

Molecular epidemiology of Staphylococcus aureus from Lambaréné, Gabon

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