Origin, evolution, and global transmission of community-acquired
            <i>Staphylococcus aureus</i>
            ST8

Strauß, Lena; Stegger, Marc; Akpaka, Patrick Eberechi; Alabi, Abraham; Breurec, Sébastien; Coombs, Geoffrey W.; Egyir, Beverly; Larsen, Anders Rhod; Laurent, François; Monecke, Stefan; Peters, Georg; Skov, Robert; Strommenger, Birgit; Vandenesch, François; Schaumburg, Frieder; Mellmann, Alexander

doi:10.1073/pnas.1702472114

Cited by 132 publications

(190 citation statements)

References 67 publications

(111 reference statements)

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“…Clean reads were used for de novo assembly with SPAdes v3.6.2 (Bankevich et al, 2012). Only assemblies that harbored ≥95% of core genome (cg) MLST targets were used for further analysis as previously described (Strauß et al, 2017). If the criteria were not met, the sample was re-sequenced.…”

Section: Whole-genome Sequencing and Assemblymentioning

confidence: 99%

The Genomic Context for the Evolution and Transmission of Community-Associated Staphylococcus aureus ST59 Through the Food Chain

Pang

Zhang

et al. 2020

Front. Microbiol.

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Sequence type 59 (ST59) is a predominant clonal lineage of community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) in Asia. Despite its increasing clinical relevance in China, the evolution and geographic expansion of ST59 has been relatively uncared for. Previous study has shown that ST59 was the predominant clone in food-related MRSA in China. This study compared the genomes of 87 clonal complex (CC) 59 S. aureus isolates sourced from food chain and infection cases to reconstruct the molecular evolution and geographical spread of ST59. Accordingly, three major sub-clades of ST59 were identified and these did not correlate with isolation source or location. Phylogenetic analysis estimated that ST59 in mainland China diverged from a most common recent ancestor around 1974, and most of the cases of cross-country transmission occurred between 1987 and 2000. Notably, two recent events of crosscountry transmission through the food chain were observed, the isolates from these events diverged within relatively short time intervals. These isolates also showed high similarity in terms of their core genome, accessory genes, and antibiotic resistance patterns. These findings provide a valuable insight into the potential route of ST59 expansion in China and indicate a need for robust food chain surveillance to prevent the spread of this pathogen.

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Section: Whole-genome Sequencing and Assemblymentioning

confidence: 99%

The Genomic Context for the Evolution and Transmission of Community-Associated Staphylococcus aureus ST59 Through the Food Chain

Pang

Zhang

et al. 2020

Front. Microbiol.

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“…CC 8 cluster composed of two clades ST 8 (MSSA) and ST 241 (MRSA) with the two clades sharing a recent common ancestor. Studies have shown that MSSA isolates of CC 8 act as reservoirs for MRSA pending acquisition of the staphylococcal cassette [52,53].…”

Section: Discussionmentioning

confidence: 99%

Strain typing and characterization of virulence genes in clinicalStaphylococcus aureusisolates from Kenya

Kyany’a

Nyasinga

Matano³

et al. 2018

Preprint

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“…Molecular evolution of MRSA has been favored by horizontal gene transfer [56] and clonal dissemination of certain strains [83][84][85].…”

Section: Genetic Structure Of the Population Of S Aureusmentioning

confidence: 99%

“…In the 1990s, a new type of MRSA appeared in the USA causing infections in the community among healthy and younger people who had no history of hospital admission or medical treatment in the previous year was reported in Western Australia [70]. These types of MRSA strains were described as CA-MRSA [85,93].…”

Section: Epidemiology Of Methicillin-resistant S Aureusmentioning

confidence: 99%

Typification Methods and Molecular Epidemiology of Staphylococcus aureus with Methicillin Resistance

Vivas

Gutierrez²

2019

Staphylococcus Aureus

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Recent interest in the study of Staphylococcus aureus derives from the high frequency of antibiotic-resistant strains that cause frequent outbreaks of infection, especially methicillin-resistant S. aureus (MRSA). The objective of this chapter was to study the population genetic structure and the origin of MRSA isolation. Classification of staphylococcal cassette chromosome mec (SCCmec) is the most important method to identify and define the S. aureus methicillin-resistant clonal nature. Molecular epidemiological studies have demonstrated dissemination patterns of few strains which are responsible for the important worldwide problem. There is a predominance of pandemic clones of MRSA associated to hospital-acquired infections (HA-MRSA) which has been replaced today by communityacquired strains (CA-MRSA). Understanding the epidemiology and clonality of S. aureus infections has important implications for future efforts to control of the emergence of multidrug-resistant strains and the spread of clones resistant and sensible to methicillin.

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Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8

Cited by 132 publications

References 67 publications

The Genomic Context for the Evolution and Transmission of Community-Associated Staphylococcus aureus ST59 Through the Food Chain

The Genomic Context for the Evolution and Transmission of Community-Associated Staphylococcus aureus ST59 Through the Food Chain

Strain typing and characterization of virulence genes in clinicalStaphylococcus aureusisolates from Kenya

Typification Methods and Molecular Epidemiology of Staphylococcus aureus with Methicillin Resistance

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