Is ADHD an inflammation-related disorder?

Binici, Nagihan Cevher; Kutlu, Ayşe

doi:10.5455/apd.5132

Cited by 5 publications

(14 citation statements)

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“…Yorbik et al (22) reported increased MPV as an indicator of the inflammatory response in ADHD. Avcil et al (19) found MPV, NLR, and PLR levels were higher than the controls, Binici et al (23) reported only MPV levels were higher in ADHD compared to the control group but this difference was not significant in the analyses performed with comorbidity and body mass index. In our study, we excluded all psychiatric disorders and obese patients except ODD and so body mass index was not evaluated as a cofactor.…”

Section: Discussionmentioning

confidence: 96%

“…In a study on platelet and MPV levels in ADHD, MPV found to be higher than controls, but no difference found in platelet levels (22). There are some studies which indicate NLR as an inflammatory marker can increase in depression, bipolar disorder and schizophrenia (19,(23)(24)(25)(26). PLR is a sensitive inflammatory marker and prognostic factor in some malignancies (27).…”

Section: Discussionmentioning

confidence: 99%

“…In high grade inflammatory disease, MPV levels negatively correlated with inflammation (29)(30)(31) however, MPV levels found to be increased in low grade inflammatory diseases such as embolism and infective endocarditis (21,32). MPV was also investigated in psychiatric disorders such as bipolar disorder, depression, anxiety disorder, panic disorder, suicide attempt, and ADHD (23,(33)(34)(35)(36). In this study, MPV and BASO levels were found to be high, especially in boys, but no significant difference was observed in other inflammatory and hematological markers.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, MONO levels for hyperactivity subtype and MPVLR for attentiondeficit subtype may be a significant marker. In the literature, MONO levels did not differ between ADHD and controls, and did not investigate in ADHD subtypes (23). Another marker, MPVLR is a strong predictor of diabetic nephropathy (42), in the diagnosis of childhood appendicitis and the differentiation of appendicitis perforation (43) and early and late mortality in ST elevated myocardial infarction (44).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Aksu

Dağ

2020

Düzce Tıp Fakültesi Dergisi

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Aim: It was aimed to evaluate the hematological inflammatory markers in treatment-naive and comorbidity-free children and adolescents with attention deficit and hyperactivity disorder (ADHD) in this study. Material and Methods: One hundred sixty-nine children aged 6-18, who were diagnosed with ADHD according to DSM-5 criteria were included in the study. Age and sex-matched 59 healthy children without any psychiatric and/or medical disorder were included as a control group. The children who had an intellectual disability and/or autism spectrum disorder, acute, chronic or inflammatory diseases were excluded from the study. Smoking, obesity and using psychotropic medications and lack of data in records were other exclusion criteria. ADHD and control groups were compared in terms of sociodemographic characteristics, inflammatory markers and hematological parameters. Results: Mean platelet volume (MPV) and Basophil (BASO) levels were significantly higher in the ADHD group compared to the control group and this statistical difference was only observed for boys. In hyperactivity subtype, red cell distribution width (RDW), lymphocyte (LYMPH) and monocytes (MONO) were higher; in attention deficit subtype mean platelet volume-to-lymphocyte ratio (MPVLR) was higher than all other subtypes and control group. MPV was similar in three subtypes, and were higher in all of them than the control group. Conclusion: This study revealed that MPV and BASO tend to be higher in the ADHD group especially in boys. Hematological biomarkers may be useful for diagnosis of ADHD and determination of ADHD subtypes but data on this subject are insufficient and more comprehensive studies are needed.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Aksu

Dağ

2020

Düzce Tıp Fakültesi Dergisi

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“…However, these studies had confl icting results. Avcil reported that NLR, PLR, MLR and MPV values were signifi cantly higher in 82 children with ADHD, compared to the control group (27), whereas Binici et al reported that NLR, PLR and MPV in 65 children with ADHD was not statistically different as compared to the control group (28). As far as we know, no previous studies have investigated eosinophil/lymphocyte ratio (ELR), basophil/lymphocyte ratio (BLR) and PDW, which are considered infl ammatory markers in children and adolescents with ADHD.…”

Section: Introductionmentioning

confidence: 97%

Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

Uzun¹

2021

BLL

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AIM: This study aims to investigate whether there is a relationship between attention-defi cit/hyperactivity disorder (ADHD) and infl ammation, using hematologic infl ammatory parameters in a large sample of children and adolescents. METHOD: This retrospective study comprises 347 children and adolescents with ADHD between 6 and 17 years of age who met the inclusion criteria as well as 205 healthy children and adolescents in the control group. Serum parameters such as white blood cell (WBC), neutrophil, lymphocyte, platelet, monocyte, eosinophil and basophil counts, mean platelet volume (MPV), and platelet distribution width (PDW) were recorded from complete blood count tests at the time of admission, while neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and other ratios were calculated based on these counts. RESULTS: NLR, PLR, MPV, PDW, WBC and neutrophil counts were signifi cantly higher in children and adolescents with ADHD than in the control group. In the ADHD group, NLR, WBC and neutrophil counts were signifi cantly higher in girls than in boys. CONCLUSIONS: The results of this study support the hypothesis that infl ammation plays an important role in the complex pathophysiology of ADHD. In addition, our data confi rm that easily obtainable and reliable hematological parameters can be used when investigating the role of infl ammation in ADHD etiology (Tab. 4, Ref.

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The Interplay Between Blood Inflammatory Markers, Symptom Domains, and Severity of ADHD Disorder in Children

Abdel Samei,

Mahmoud,

Salem Boshra

et al. 2023

J Atten Disord

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Objective: ADHD has a multi-factorial etiology among which the inflammatory theory presupposition. We aimed to explore the interplay between blood inflammatory markers; neutrophil lymphocyte ratios (NLR), platelet\lymphocyte ratio (PLR), mean platelet volume (MPV), symptom domains, and severity of ADHD. Method: A total of 50 children with ADHD and 50 healthy controls were recruited. Children were assessed using the mini-international neuropsychiatric interview for children and adolescents (MINI-KID), the Wechsler intelligence scale for children, the Conners’ parent rating scale. Then, NLR, PLR, and MPV were measured. Results: There was a statistically significant difference between children with ADHD and the control group with regard to all blood inflammatory markers (except platelet count). The subtypes and severity of ADHD had no significant relation with NLR, PLR, and MPV. Conclusion: blood inflammatory markers are significantly high in children with ADHD but could not predict specific symptom domains or severity.

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Is ADHD an inflammation-related disorder?

Cited by 5 publications

References 0 publications

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

The Interplay Between Blood Inflammatory Markers, Symptom Domains, and Severity of ADHD Disorder in Children

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