Is accelerated corneal collagen cross-linking for keratoconus the way forward? Yes

Tsatsos, Michael; MacGregor, Cheryl; Kopsachilis, Nikolaos; Anderson, David F.

doi:10.1038/eye.2014.97

Cited by 11 publications

(6 citation statements)

References 13 publications

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“…[8][9][10][11][12] Currently, there is still a debate on the effectiveness between conventional CXL and its accelerated counterparts. 13,14 A corneal stromal demarcation line indicating the transition between the anterior cross-linked and posterior untreated corneal stroma could be observed using a slit lamp by as early as 2 weeks after CXL. 15 The depth of this line has been postulated as an indirect measurement of cross-linking effectiveness.…”

mentioning

confidence: 99%

Comparison of the Central and Peripheral Corneal Stromal Demarcation Line Depth in Conventional Versus Accelerated Collagen Cross-Linking

Chan

Lai

et al. 2015

Cornea

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confidence: 99%

Comparison of the Central and Peripheral Corneal Stromal Demarcation Line Depth in Conventional Versus Accelerated Collagen Cross-Linking

Chan

Lai

et al. 2015

Cornea

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“…Combined PRK and CXL has shown promising results in the treatment of keratoconus and postlaser-assisted in situ keratomileusis ectasia, where only partial surface ablation is performed. [67] In this case, PRK ablation was performed for the whole refractive correction of −7.75/−0.75 × 10 (right eye) and −7.50/−1.00 × 170 (left eye). The addition of CXL in the presence of ocular surface disease may have been a contributing factor to the complicated outcome.…”

Section: Discussionmentioning

confidence: 99%

Combined photorefractive keratectomy and cross-linking. Pushing the limits

Tsatsos

Athanasiadis

MacGregor³

et al. 2019

Taiwan J Ophthalmol

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Correction of refractive error through laser-assisted means has soared in popularity in recent years, allowing it to become an increasingly routine surgical procedure. Technique refinement and adjustments resulted in laser-assisted refractive surgery to be combined with treatments such as collagen cross linking (CXL). This has broadened safety parameters and widened the treatment boundaries. Laser correction combined with CXL has been advocated in the treatment of high refractive errors as a safe option for full refractive correction while increasing corneal biomechanical stability. We present a complicated case where a young female patient with a preoperative best-corrected visual acuity (BCVA) of 20/20 in each eye was fully corrected by excimer laser followed by CXL. Factors potentially leading to inflammation, such as ocular surface disease, in addition to laser treatment and CXL, resulted in persistent epithelial defect followed by corneal melt and subsequent thinning. After the treatment, the patient relies on rigid gas-permeable contact lenses, achieving a BCVA of 20/25 and 20/23 in the right eye and left eye, respectively.

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“…A few clinical studies also demonstrated the treatment efficacy and safety of these accelerated protocols, 9Y12 although no general consensus on this form of treatment has been made. 13,14 thickness. Subsequently, the cornea is photoactivated using identical treatment parameters as described previously.…”

Section: Surgical Procedures Of Corneal Collagen Cross-linkingmentioning

confidence: 99%