Is a specific eyelid patch test series useful? Results of a French prospective study

Assier, Haudrey; Tétart, F.; Avenel-Audran, M.; Barbaud, A.; Bouëdec, Marie-Christine Ferrier-Le; Giordano‐Labadie, F.; Milpied, B.; Amsler, E.; Collet, E.; Girardin, P.; Soria, Angèle; Waton, J.; Truchetet, F.; Bourrain, Jean‐Luc; Géner, G.; Bernier, C.; Raison‐Peyron, Nadia

doi:10.1111/cod.13040

Cited by 18 publications

(15 citation statements)

References 25 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The high rate of fragrance allergy in this cohort (30.4%) echoes the results from multiple other studies that found fragrances to be major agents in eyelid ACD (Amin and Belsito, 2006, Ayala et al, 2003, Ockenfels et al, 1997, Shah et al, 1996, Valsecchi et al, 1992). High rates of contact sensitization to hydroperoxides of linalool and limonene reflect the high prevalence in the literature (Assier, 2018, Dittmar and Schuttelaar, 2019, Nath et al, 2017) and reinforce these as high-risk allergens. Although evidence exists that linalool and limonene may frequently cause irritant reactions (Assier, 2018), we found four of six reactions to be more pronounced at 5 days than at 2 days, which supports a diagnosis of ACD.…”

Section: Discussionmentioning

confidence: 65%

“…High rates of contact sensitization to hydroperoxides of linalool and limonene reflect the high prevalence in the literature (Assier, 2018, Dittmar and Schuttelaar, 2019, Nath et al, 2017) and reinforce these as high-risk allergens. Although evidence exists that linalool and limonene may frequently cause irritant reactions (Assier, 2018), we found four of six reactions to be more pronounced at 5 days than at 2 days, which supports a diagnosis of ACD. The other two reactions experienced a stable or decrease response.…”

Section: Discussionmentioning

confidence: 65%

See 1 more Smart Citation

Investigating the role of allergic contact dermatitis in residual ocular surface disease on dupilumab (ROSDD),,

Raffi

Suresh

Fishman

et al. 2019

International Journal of Women's Dermatology

View full text Add to dashboard Cite

BackgroundThe mechanisms underlying eye-related complications with dupilumab are poorly understood.ObjectiveThis study aimed to determine the incidence and characteristics of ocular complications with dupilumab and the prevalence of comorbid allergic contact dermatitis in the same subpopulation.MethodsThis is a retrospective chart review of 48 patients with atopic dermatitis who received dupilumab. For patients with eye involvement at first follow-up, we discuss the presence of eyelid dermatitis, blepharitis, or conjunctivitis and analyze available patch test findings in patients with ocular complications while treated with dupilumab.ResultsA total of 14 patients (29.2%) showed eye involvement while on dupilumab, all of whom experienced eye involvement prior to dupilumab. The results of the patch test were most commonly positive for emulsifier/surfactants (42.5%) and fragrances (30.4%). Nine patients experienced improvement with allergen avoidance subsequent to patch testing, and four of nine patients’ conditions cleared almost entirely. This is a non-randomized study in a small cohort of patients. Only 18 patients had their disease confirmed by an ophthalmologist.ConclusionAll patients with eye involvement while on dupilumab had a history of eye involvement prior to dupilumab, suggest that dupilumab may encourage rather than cause ocular surface inflammation. Significant improvement after patch testing in nearly half of patients suggests that allergic contact dermatitis contributes to some cases of dupilumab-associated eye complications.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 65%

Investigating the role of allergic contact dermatitis in residual ocular surface disease on dupilumab (ROSDD),,

Raffi

Suresh

Fishman

et al. 2019

International Journal of Women's Dermatology

View full text Add to dashboard Cite

show abstract

“…70 In seven studies in which patients with eyelid dermatitis or periorbital dermatitis were patch tested with MP, frequencies of sensitization ranged from 1.7% to 17%, but in five of the seven studies, the frequency was <7%. [72][73][74][75][76][77][78] In three investigations in which relevance was addressed, rates of relevant reactions were 43%, 77 58%, 78 and 75%, 74 but the culprit products were not mentioned. In four studies with a control group, the frequency of sensitization to MP was significantly lower than in routine testing.…”

Section: Relevance and Causative Productsmentioning

confidence: 99%

Myroxylon pereirae resin (balsam of Peru) – A critical review of the literature and assessment of the significance of positive patch test reactions and the usefulness of restrictive diets

Groot¹

2019

Contact Dermatitis

View full text Add to dashboard Cite

In this article, contact allergy to Myroxylon pereirae resin (MP) (balsam of Peru) is reviewed. The topics presented include the uses, the chemical composition, the frequency of sensitization, the relevance of positive reactions, the MP-containing products causing allergic contact dermatitis, co-reactivity with other fragrance and nonfragrance materials, the sensitizers, the usefulness of MP as a "marker" of fragrance allergy, and the effectiveness of, and indications for, "balsam-restrictive" diets. Sensitization to MP occurs in 4% to 8% of patients routinely tested for suspected contact dermatitis. There are few adequate data on relevance. Topical pharmaceuticals were formerly, but are not today, important sources of sensitization. Cosmetics and foods or drinks are hardly ever products responsible for sensitization to MP. Positive patch test reactions in the large majority probably result from previous sensitization to MP constituents because of their presence in fragrances and fragranced products, MP thereby acting as marker (or "indicator") of fragrance allergy. However, fragrance mix I is a more sensitive marker, and the added diagnostic value of testing with MP is unknown. The allergenic ingredients of MP include isoeugenol, eugenol and cinnamyl alcohol, but there are other-largely unknown-chemicals that are responsible for contact allergy. Suggestions are given for further research to address questions thus far unanswered and to improve patient care. K E Y W O R D Sbalsam of Peru, balsam-restrictive diet, chemical composition, eugenol, cinnamyl alcohol, coniferyl benzoate, fragrance, isoeugenol, Myroxylon pereirae resin, perfume, fragrance marker, contact allergy

show abstract

“…Identification of ACD as the most frequent cause of eyelid dermatitis has been well established, especially in the dermatologic literature. 4,8,[12][13][14][15] Eye care providers are quick to point to topical ophthalmic medications as potential ACD triggers. However, ACD is often misdiagnosed, or ophthalmologists and optometrists may be unsure of therapeutic options if patients fail to improve despite avoidance of ophthalmic medications.…”

Section: Introductionmentioning

confidence: 99%

Seven Common Allergen Groups Causing Eyelid Dermatitis: Education and Avoidance Strategies

Huang¹,

Yiannias²,

Killian³

et al. 2021

OPTH

View full text Add to dashboard Cite

Objective: Eyelid dermatitis is most commonly attributed to allergic response. This retrospective clinical study identifies common allergens with eyelid involvement and addresses a literary gap by providing a clear approach for effective management of periorbital allergic contact dermatitis (ACD) recurrence. Methods: Charts of 215 patients diagnosed with periorbital dermatitis who were patch tested with Mayo Clinic Standard Series, Extended Standard Series, and personal products from 2013 to 2017 were examined. Positive reaction rates for patients with eyelid involvement were compared to those without. Findings were also compared to North American Contact Dermatitis Group (NACDG) 2013-2014 and Mayo Clinic Contact Dermatitis Group (MCCDG) 2011-2015 general patch test populations. Results: The 215 patients showed more common allergy to shellac, benzalkonium chloride, acrylates, and surfactants than the NACDG and MCCDG study populations. Periorbital ACD allergen groups eliciting the highest positive reaction rates were, in descending order: metals, shellac, preservatives, topical antibiotics, fragrances, acrylates, and surfactants. Of the corticosteroids, only tixocortol pivalate (the screening agent for prednisolone and fluorometholone) and budesonide elicited positive reactions. Conclusion:The top seven eyelid ACD allergen groups were identified. Avoidance of these allergens can be straightforward, with initial empiric counseling and free, online allergen avoidance programs. Patients who are unresponsive to avoidance should undergo patch testing.

show abstract

Is a specific eyelid patch test series useful? Results of a French prospective study

Abstract: In French patients, testing for EACD with the extended baseline series and personal products, also including ROATs and use tests, appears to be adequate, considering the currently relevant positive test reactions. The regular addition of an eyelid series does not seem to be necessary.

Cited by 18 publications

References 25 publications

Investigating the role of allergic contact dermatitis in residual ocular surface disease on dupilumab (ROSDD),,

Investigating the role of allergic contact dermatitis in residual ocular surface disease on dupilumab (ROSDD),,

Myroxylon pereirae resin (balsam of Peru) – A critical review of the literature and assessment of the significance of positive patch test reactions and the usefulness of restrictive diets

Seven Common Allergen Groups Causing Eyelid Dermatitis: Education and Avoidance Strategies

Contact Info

Product

Resources

About