Is 2–6 h optimal window for ICSI?

Patel, Garima; Singh, Neeta; Sethi, Ankita

doi:10.1007/s10815-021-02315-w

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…[ 11 ] However, this lacks clinical relevance since the CPR and LBR were not compared. [ 31 ] Whereas in our study, both fertilisation rate and CPR were similar between the two compared groups.…”

Section: Discussioncontrasting

confidence: 44%

Two-six hours is the optimal timing of intracytoplasmic sperm injection after oocyte pickup: Single-centre 10 years cohort study

et al. 2022

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Section: Discussioncontrasting

confidence: 44%

Two-six hours is the optimal timing of intracytoplasmic sperm injection after oocyte pickup: Single-centre 10 years cohort study

et al. 2022

Self Cite

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“…ICSI should be conducted for a period of time during denudation, as oocytes should be restored during this timeframe ( 3 ). In terms of laboratory workflow, researchers have found that performing ICSI and oocyte denudation at any point within the currently accepted timeframe does not appear to negatively impact fertilization and blastulation success in patients with a favorable prognosis ( 5 ). It is highly unlikely that variability in the timing of ICSI during this period will have an significant impact on cycle outcome as oocyte appears to possess a physiological tolerance for fertilization during the commonly accepted 2-6 hour window ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of the time interval between denudation and ICSI on fresh embryo transfer reproductive outcomes: a retrospective study

Xiao,

Xue,

Zhang

et al. 2024

Front. Endocrinol.

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PurposeThis study aims to determine if the incubation after oocyte denudation before Intra-cytoplasmic sperm injection (ICSI) affects the clinical pregnancy rate.MethodsThis was a retrospective, consecutive data analysis of 1370 patients who underwent ICSI cycles at the Department of Reproductive Medicine of West China Second University of Sichuan University (Chengdu, Sichuan) between January 2020 and July 2022. The primary outcome was the clinical pregnancy rate. The second outcome included fertilization rate, biochemical pregnancy rate, and miscarriage rates.ResultsA total of 1370 continuous fresh transferred ICSI cycles were analyzed. Multivariate linear regression and logistic regression analysis of factors related to clinical pregnancy rates revealed that clinical pregnancy rates were significantly associated with denudation (DEN)-ICSI time interval. Long DEN-ICSI intervals are associated with a higher clinical pregnancy rate during fresh embryo transfer.ConclusionThe DEN-ICSI time interval is an independent factor for clinical outcomes in fresh ICSI transfer cycles.

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The Timing of Intracytoplasmic Sperm Injection Relative to Oocyte Retrieval: A Systematic Review and Meta-Analysis

Gupta

Thorrowgood

Ashton

et al. 2022

FandR

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Background: It is currently inconclusive whether different intracytoplasmic sperm injection (ICSI) timings post oocyte retrieval (POR) lead to altered chance of clinical pregnancy and live birth following in vitro fertilization (IVF) treatment. This study, therefore, aimed to synthesize literature-based evidence for better clinical guidance regarding ICSI practice. Methods: A systematic review and meta-analysis were performed according to PRISMA guidelines. Studies were searched for in PubMed, MEDLINE, EMBASE, and the Cochrane Library. Outcome endpoints included clinical pregnancy and live birth rates (LBRs). Results: A total of 605 records were retrieved in the initial search. After exclusion, 30 articles were included for further screening for eligibility. For meta-analysis, 1 prospective and 5 retrospective cohort studies were included for pooled analysis, from which clinical pregnancy rates (CPRs) were evaluated in 6 studies while LBRs were evaluated in 3 studies. CPRs were comparable when ICSI was performed at (a) [Formula: see text]2 hours POR (risk ratio or RR = 1.00, 95% confidence interval [CI] 0.94–1.08) vs 2+ hours, (b) [Formula: see text]3 hours (RR = 1.01, 95% CI 0.88–1.16) vs 3+ hours, (c) [Formula: see text]4 hours (RR = 0.99, 95% CI 0.93–1.05) vs 4+ hours, (d) [Formula: see text]5 hours (RR = 0.98, 95% CI 0.93–1.02) vs 5+ hours, and (e) [Formula: see text]6 hours (RR = 1.05, 95% CI 0.90–1.23) vs 6+ hours. However, LBR was reduced when ICSI was performed [Formula: see text]5 hours POR vs 5+ hours (RR = 0.94, 95% CI 0.89–0.99), but such reduction disappeared when comparing [Formula: see text]6 hours POR (RR = 1.09, 95% CI 0.85–1.38) vs 6+ hours. Conclusions: CPRs remain comparable when ICSI is performed at a range of timings up to 6-hour POR. However, LBR may benefit slightly by scheduling ICSI between 5- and 6-hour POR.

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Is 2–6 h optimal window for ICSI?

Cited by 3 publications

References 4 publications

Two-six hours is the optimal timing of intracytoplasmic sperm injection after oocyte pickup: Single-centre 10 years cohort study

Two-six hours is the optimal timing of intracytoplasmic sperm injection after oocyte pickup: Single-centre 10 years cohort study

Effect of the time interval between denudation and ICSI on fresh embryo transfer reproductive outcomes: a retrospective study

The Timing of Intracytoplasmic Sperm Injection Relative to Oocyte Retrieval: A Systematic Review and Meta-Analysis

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