Irritant and allergic reactions to topically applied Micatin® cream

Tr, Wade; He, Jones; Wa, Artis

doi:10.1111/j.1600-0536.1979.tb04831.x

Cited by 8 publications

(1 citation statement)

References 7 publications

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“…In many cases reported, only pharmaceutical products containing imidazole derivatives were tested. While results suggested that the active ingredient was the allergen, the role of vehicle components could not always be excluded (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), even when the ingredients of the vehicle reacted negatively (7). In some other studies, pharmaceutical products and only some imidazole derivatives were investigated.…”

Section: Identification Problemsmentioning

confidence: 99%

Contact allergy to imidazoles used as antimycotic agents

et al. 1995

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The present article reviews the literature (up to 1994) on contact sensitivity to imidazoles and presents the results obtained from 15 patients observed at the Contact Allergy Unit in Leuven. The frequency as well as the cross-reaction patterns described are analyzed. Although allergic contact reactions may have been missed in the past (mainly because of problems with the correct choice of vehicle for patch testing), they seem to be relatively infrequent in view of their widespread use. The imidazole derivatives most frequently reported to be allergens are miconazole, econazole, tioconazole, and isoconazole. As far as cross-reactivity is concerned, statistically significant associations were found in the patient data between miconazole, econazole, and isoconazole; between sulconazole, miconazole, and econazole; and also between isoconazole and tioconazole. Patients sensitive to phenylethyl imidazoles (except ketoconazole) needing antimycotic therapy should be advised to use ketoconazole, clotrimazole, bifonazole, or, perhaps, the new flutrimazole. Clearly, non-imidazole antifungals can also be used.Key words: allergic contact dermatitis; antimycotic agents; imidazoles; cross-sensitivity; medicaments; ketoconazole; clotrimazole; bifonazole; miconazole; tioconazole; croconazole. © Munksgaard, 1995. Accepted for publication 23 November 1994Since they were first introduced in 1969, imidazoles have probably become the most widely used of all antifungals in human and veterinary medicine. Moreover, imidazole derivatives such as enilconazole are also used for antifungal protection of citrus fruit, vegetables, and other plants (1).Considering the tremendous amounts of imidazole derivatives used and the possibility of them being stored in the skin (2), the paucity of published reports on their contact sensitization capacity would indicate that they are very weak allergens. However, a growing number' of case reports and real or quasi-cross-reaction studies have made it possible to evaluate which are the "stronger" and which the "weaker" allergens, as well as potential cross-reaction patterns.To evaluate studies concerning frequency as well as cross-reaction patterns described, we surveyed the available literature up to 1994 on contact sensitivity to imidazoles and included the results of 15 of our own patients with imidazole contact allergy, with a view to a better understanding of the chemical structure required for sensitization and crosssensitization, and also to proposals for an imidazole series for testing and for therapeutic alternatives for patients sensitive to particular imidazole derivatives.

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Section: Identification Problemsmentioning

confidence: 99%

Contact allergy to imidazoles used as antimycotic agents

et al. 1995

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Drugs Used Topically

Andersen¹,

Maibach²

1983

Handbook of Experimental Pharmacology

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Allergic Contact Dermatitis of the Anogenital Region in Men and Women

Cheng

Fernández‐Peñas

2020

J Low Genit Tract Dis

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Objectives Allergic contact dermatitis is an uncommon but important cause of skin disease in the anogenital region. Relevant allergens are described in women and less commonly in men. The aim of this study was to describe outcomes of patch testing in men and women presenting with anogenital dermatoses. Materials and Methods Cases patch tested for anogenital conditions at 2 patch test clinics in Sydney, Australia, from 2002 to 2017 were reviewed. Positive and relevant patch test reactions were recorded. Results Thirty-seven women and 27 men were included. Dermatitis was the most common diagnosis, followed by psoriasis and lichen sclerosus. Thirty percent had a final diagnosis of allergic contact dermatitis. The most frequent relevant allergens were fragrance mix I (9%), patients own products (9%), Myroxylon pereirae (8%), cocamidopropyl betaine (3%), and benzocaine (3%). Conclusions The top positive and relevant allergens seen were in concordance with other reports from Australia and the rest of the world. Fragrances and medicaments are common allergens, and it is recommended that products used on anogenital skin be fragrance free. Testing patients own products is imperative.

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Irritant and allergic reactions to topically applied Micatin® cream

Cited by 8 publications

References 7 publications

Contact allergy to imidazoles used as antimycotic agents

Contact allergy to imidazoles used as antimycotic agents

Drugs Used Topically

Allergic Contact Dermatitis of the Anogenital Region in Men and Women

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