In this paper we continue our study of Groenewold-Van Hove obstructions to quantization. We show that there exists such an obstruction to quantizing the cylinder T * S 1 . More precisely, we prove that there is no quantization of the Poisson algebra of T * S 1 which is irreducible on a naturally defined e(2) × R subalgebra. Furthermore, we determine the maximal "polynomial" subalgebras that can be consistently quantized, and completely characterize the quantizations thereof. This example provides support for one of the conjectures in [GGT], but disproves part of another. Passing to coverings, we also derive a no-go result for R 2 which is comparatively stronger than those originally found by Groenewold [Gr] and Van Hove [vH].