We discuss the Groenewold-Van Hove problem for R 2n , and completely solve it when n = 1. We rigorously show that there exists an obstruction to quantizing the Poisson algebra of polynomials on R 2n , thereby filling a gap in Groenewold's original proof. Moreover, when n = 1 we determine the largest Lie subalgebras of polynomials which can be consistently quantized, and explicitly construct all their possible quantizations.