Irradiation Reactions in the Bladder: Their Occurrence and Clinical Course Following The Use of X-Ray and Radium in the Treatment of Female Pelvic Disease

Watson, Ernest M.; Herger, Charles C.; Sauer, Hans R.

doi:10.1016/s0022-5347(17)69739-8

Cited by 29 publications

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“…Alterations also take place in the urothelial lining, but with ulcers and crystal inclusions. In rare instances even urothelial cancer may develop (Watson et al, 1947;Kottmeier, 1953;Basu Mallik, 1962;Maier, 1972). One of the reasons why such effects occur after a long time delay is probably that both the urothelium, the endothelium and the smooth muscle bundles with the connective tissue components have a very long turnover time (Farsund, 1975;Stewart et al, 1980).…”

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Some Long‐Term Cell Kinetic Effects of Ionizing Radiation On Mouse Bladder Urothelium

Reitan

1986

Cell Proliferation

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The cell kinetics of the mouse bladder urothelium were followed with tritiated thymidine pulse labelling and flow cytometry for one year after irradiation with electrons. No perturbations were registered after 10 Gy. Three to four weeks after 20 G y an elevation of the labelling index with a subsequent return to normal was seen. Flow cytometry revealed some increase in the proportion of octaploid nuclei at the same time. From about six months after irradiation the normal polyploidization decreased. The urothelium turned into a mainly diploid cell population. The proportion of diploid S phase cells also increased. The data give some support to the model hypothesis of reactive proliferation in a 'flexible' tissue, according to Wheldon et al. (1982). . (1982) Early and late morphological changes (Including carcinoma of the urothelium) induced by irradiation of the rat urinary bladder. Br. J. Cancer. 46,403. BASU MALLIK, M.K. (1962) Study of radiation necrosis of the urinary bladder following treatment of carcinoma of the cervix. Am. J. Obslet. Gynaecol. 83, 393. BECK, H.P. (1980) Evaluation of flow cytometric data of human tumours. Correction procedures for background and cell aggregations.

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Some Long‐Term Cell Kinetic Effects of Ionizing Radiation On Mouse Bladder Urothelium

Reitan

1986

Cell Proliferation

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The subcellular basis of damage to the human urinary bladder induced by irradiation

Antonakopoulos

Hicks

Berry

1984

The Journal of Pathology

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The effects of x-irradiation on the subcellular structure of the human urinary bladder were investigated by electron microscopic examination of biopsies taken during check cystoscopies from 25 patients between 1 month and 22 years after completion of a course of therapeutic radiation. All tissues of the bladder wall were damaged to some extent by the treatment. In the urothelium this was reflected by the development of more than the usual numbers of lysosomes and autophagic vacuoles in all cell layers. In the bladder wall, large often binucleate or multinucleate fibroblasts were prominent and persistent in all specimens and were associated with the development of progressive fibrosis. The vasculature and the muscle coats of the bladder wall were also damaged. In the blood vessels many endothelial cells were oedematous or necrotic and some intravascular coagulation was also observed. Smooth muscle cells became oedematous soon after irradiation, and after longer time intervals there was focal death and loss of individual muscle cells. The observed degeneration and extensive necrosis of the bladder wall, which involved severe destruction and disorganization of the muscular layers, is sufficient to explain the clinical sequelae of bladder irradiation, namely loss of elasticity, reduced capacity and incomplete micturition with residual urine.

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The Kidney and the Bladder

Green¹

1989

Long-Term Complications of Therapy for Cancer in Childhood and Adolescence

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Irradiation Reactions in the Bladder: Their Occurrence and Clinical Course Following The Use of X-Ray and Radium in the Treatment of Female Pelvic Disease

Cited by 29 publications

References 5 publications

Some Long‐Term Cell Kinetic Effects of Ionizing Radiation On Mouse Bladder Urothelium

Some Long‐Term Cell Kinetic Effects of Ionizing Radiation On Mouse Bladder Urothelium

The subcellular basis of damage to the human urinary bladder induced by irradiation

The Kidney and the Bladder

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