Irradiation of gold nanoparticles by x‐rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production

Leung, M.; Chow, James C. L.; Chithrani, Devika B.; Lee, Martin J. G.; Oms, B; Jaffray, David A.

doi:10.1118/1.3539623

Cited by 224 publications

(208 citation statements)

References 45 publications

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“…The "Penelope Physics List" has been used in many recent publications, for either calculating the RDD, DER, or in order to create dose distributions to import to a radiobiological model (Leung et al 2011, Lin et al 2015. This selection is based on the original paper presenting the suitability of the "Penelope" models for nanodosimetric (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…This is due to the production of low energy secondary radiation which deposits energy close to the GNP, enhancing the local dose. Monte Carlo (MC) simulations for the quantification of the local dose enhancement have been implemented by many groups (McMahon et al 2011b, Leung et al 2011, Wälzlein et al 2014, Lin et al 2014, Xie et al 2015.…”

Section: Introductionmentioning

confidence: 99%

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Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Sotiropoulos

Taylor

Henthorn

et al. 2017

Biomed. Phys. Eng. Express

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Gold nanoparticles (GNPs) have shown a potential as a radiosensitizer in radiotherapy. The radiosensitization effect is thought to be linked to the increased dose deposition around the GNP. Monte Carlo simulations have been implemented for the calculation of the dose distributions around the GNPs and have been used for the calculation of the dose enhancement. They have also been imported to radiobiological models to predict biological endpoints. This work assessed the implications of different physical interaction models on the dose distribution and dose enhancement of GNPs surrounded by water under proton irradiation. The Penelope and Livermore physical interaction model implementation of the Geant4 simulation toolkit were compared considering the following parameters: i) GNP size, ii) proton energy, and iii) alternative physics model parameters in the gold or water medium. We found that neither the dose distribution nor the dose enhancement is sensitive to the model selection after the first 100 nm from the GNP surface. Within the first 100 nm the Livermore models calculated a higher dose, attributed to a higher production of low energy secondary electrons inside the GNP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Sotiropoulos

Taylor

Henthorn

et al. 2017

Biomed. Phys. Eng. Express

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“…In this case, optimum DEF occurs for silver nanoparticles smaller than 30 nm homogeneously distributed in the sensitive medium. As the percentage of silver mass increases, aggregation, growth, and segregation of the particles diminish the DEF, probably due to self-absorption of dose by the silver nanoparticles 9,41,43 . Figure 2 shows that the peak-to-peak amplitude of the alanine spectrum is larger for sample containing a percentage of silver mass of 0.05% as compared with the sample containing a percentage of silver mass of 1%, which is unexpected according to the Bragg rule for composite materials 9,41,44 .…”

Section: Resultsmentioning

confidence: 99%

Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives

Guidelli

Baffa

2014

AIP Conference Proceedings

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Abstract. Metallic nanoparticles increase the delivered dose and consequently enhance tissue radio sensitization during radiation therapy of cancer. The Dose Enhancement Factor (DEF) corresponds to the ratio between the dose deposited on a tissue containing nanoparticles, and the dose deposited on a tissue without nanoparticles. In this sense, we have used electron spin resonance spectroscopy (ESR) to investigate how silver and gold nanoparticles affect the dose deposition in alanine dosimeters, which act as a surrogate of soft tissue. Besides optimizing radiation absorption by the dosimeter, the optical properties of these metal nanoparticles could also improve light emission from materials employed as radiation detectors. Therefore, we have also examined how the plasmonic properties of noble metal nanoparticles could enhance radiation detection using optically stimulated luminescence (OSL) dosimetry. This work will show results on how the use of gold and silver nanoparticles are beneficial for the ESR and OSL dosimetric techniques, and will describe the difficulties we have been facing, the challenges to overcome, and the perspectives.

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“…So, due to the poorly formed tumor vasculature, the accumulation of unlabeled nanoparticles within the tumor can occur under passive targeting by increasing the effect of permeability and retention (EPR) 38 , 39 . Several other studies demonstrated the effects of GNPs in radiation treatment of the different tumors 33 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 …”

Section: Introductionmentioning

confidence: 99%

“…But it requires significantly higher concentrations of GNPs. In an independent project by Leung et al (46) using the MC technique, it was shown that gold nanoparticles with larger diameter and concentration increase the DEF in the tumor area. This means that, to obtain more precise results and knowing the parameters effective in cancer treatment by gold nanoparticles, more studies and examinations should be carried out.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticle‐based brachytherapy enhancement in choroidal melanoma using a full Monte Carlo model of the human eye

Asadi

Vaezzadeh

Masoudi

et al. 2015

J Applied Clin Med Phys

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The effects of gold nanoparticles (GNPs) in 125I brachytherapy dose enhancement on choroidal melanoma are examined using the Monte Carlo simulation technique. Usually, Monte Carlo ophthalmic brachytherapy dosimetry is performed in a water phantom. However, here, the compositions of human eye have been considered instead of water. Both human eye and water phantoms have been simulated with MCNP5 code. These simulations were performed for a fully loaded 16 mm COMS eye plaque containing 13 125I seeds. The dose delivered to the tumor and normal tissues have been calculated in both phantoms with and without GNPs. Normally, the radiation therapy of cancer patients is designed to deliver a required dose to the tumor while sparing the surrounding normal tissues. However, as the normal and cancerous cells absorbed dose in an almost identical fashion, the normal tissue absorbed radiation dose during the treatment time. The use of GNPs in combination with radiotherapy in the treatment of tumor decreases the absorbed dose by normal tissues. The results indicate that the dose to the tumor in an eyeball implanted with COMS plaque increases with increasing GNPs concentration inside the target. Therefore, the required irradiation time for the tumors in the eye is decreased by adding the GNPs prior to treatment. As a result, the dose to normal tissues decreases when the irradiation time is reduced. Furthermore, a comparison between the simulated data in an eye phantom made of water and eye phantom made of human eye composition, in the presence of GNPs, shows the significance of utilizing the composition of eye in ophthalmic brachytherapy dosimetry Also, defining the eye composition instead of water leads to more accurate calculations of GNPs radiation effects in ophthalmic brachytherapy dosimetry.PACS number: 87.53.Jw, 87.85.Rs, 87.10.Rt

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Irradiation of gold nanoparticles by x‐rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production

Cited by 224 publications

References 45 publications

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives

Gold nanoparticle‐based brachytherapy enhancement in choroidal melanoma using a full Monte Carlo model of the human eye

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