Iron status parameters in preeclamptic women

Siddiqui, Imran; Jaleel, Anila; Kadri, Hanan M. F. Al; Saeed, Waleed Al; Tamimi, Waleed

doi:10.1007/s00404-010-1728-2

Cited by 48 publications

(36 citation statements)

References 30 publications

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“…The answer is almost certainly that it is a leakage molecule from damaged cells (126), and when in serum it is found to have lost its iron content (782–785). Serum ferritin is, as expected, raised during PE (244, 246, 249, 253, 255, 786, 787) and in many other inflammatory diseases (126), including infection [e.g., Ref. (788, 789) and above].…”

Section: Proteomic and Similar Biomarkers – Circulating And Placentalsupporting

confidence: 74%

A Dormant Microbial Component in the Development of Preeclampsia

Kell

Kenny

2016

Front. Med.

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Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE and are widely considered to contribute to its severity. These are abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress, and inflammation. What is lacking, however, is an explanation of how these themselves are caused. We here develop the unifying idea, and the considerable evidence for it, that the originating cause of PE (and of the four classes of dysregulation) is, in fact, microbial infection, that most such microbes are dormant and hence resist detection by conventional (replication-dependent) microbiology, and that by occasional resuscitation and growth it is they that are responsible for all the observable sequelae, including the continuing, chronic inflammation. In particular, bacterial products such as lipopolysaccharide (LPS), also known as endotoxin, are well known as highly inflammagenic and stimulate an innate (and possibly trained) immune response that exacerbates the inflammation further. The known need of microbes for free iron can explain the iron dysregulation that accompanies PE. We describe the main routes of infection (gut, oral, and urinary tract infection) and the regularly observed presence of microbes in placental and other tissues in PE. Every known proteomic biomarker of “preeclampsia” that we assessed has, in fact, also been shown to be raised in response to infection. An infectious component to PE fulfills the Bradford Hill criteria for ascribing a disease to an environmental cause and suggests a number of treatments, some of which have, in fact, been shown to be successful. PE was classically referred to as endotoxemia or toxemia of pregnancy, and it is ironic that it seems that LPS and other microbial endotoxins really are involved. Overall, the recognition of an infectious component in the etiology of PE mirrors that for ulcers and other diseases that were previously considered to lack one.

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Section: Proteomic and Similar Biomarkers – Circulating And Placentalsupporting

confidence: 74%

A Dormant Microbial Component in the Development of Preeclampsia

Kell

Kenny

2016

Front. Med.

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“…There was highly significant difference of mean serum ferritin concentration between cases and controls (p = 0.0001) ( Table -I). The study also showed that mean serum accordance with other similar studies like Rayman et al 6 Recent study by Siddiqui et al 8 also revealed that serum ferritin and serum iron concentration were significantly higher (p<0.05) in preeclamptic women in comparison to normal pregnant women which are similar to the findings of present study. However, Ugwaja et.…”

Section: Resultssupporting

confidence: 83%

“…However, endothelial dysfunction has been considered to play a central role in the pathophysiology of preeclampsia 5 . In many studies alteration of iron status has been claimed as a factor for vascular endothelial cell damage of preeclampsia and its consequences [6][7][8] . Iron is essential to nearly all cells but the amount of iron required by Bangladesh J Med Biochem; 5 (2) 54 R Sultana, S Ahmed, N Sultana, SM Fazlul Karim et al iron concentration in cases was 121.78±41.93 µg/dl and that in controls was 61.04±24.18 µg/dl.…”

Section: Introductionmentioning

confidence: 99%

Iron Status in Pre-Eclampsia: A Case-Comparison Study

Sultana

Ahmed²,

Sultana

et al. 2013

Bangladesh J Med Biochem

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Preeclampsia is one of the most leading causes of maternal mortality in developing countries. Many studies have demonstrated the relation between alteration of iron status and preeclampsia. The aim of the study was to assess the status of iron in preeclampsia. This case control study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in the third trimester of pregnancy attending the Obstetrics & Gynaecology Department of Dhaka Medical College Hospital were selected purposively as study subjects. Among them 50 diagnosed cases of preeclampsia were selected as cases and 50 normal healthy pregnant women as controls. Serum ferritin and serum iron concentration were measured in all study subjects. The mean serum ferritin concentration in cases and controls were 95.06±50.07 µg/l and 45.56±27.44 µg/l respectively. Mean serum iron concentration in cases was 121.78±41.93 µg/dl and that in controls was 61.04±24.18 µg/dl. The present study showed significant differences of mean serum ferritin and serum iron between cases and controls. The study revealed presence of significantly higher level of serum ferritin and serum iron in preeclamptic group.

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“…In a recent study by Siddiqui et al 28 , mean serum ferritin concentration in preeclamptics was higher than in normal pregnant women. In this study, no significant differences were found among hemoglobin concentration or hematocrit, either.…”

Section: Discussionmentioning

confidence: 81%

Is preeclampsia associated with restless legs syndrome?

Ramirez

Cabrera

Hidalgo³

et al. 2013

Sleep Medicine

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OBJECTIVE: Restless legs syndrome (RLS) is a common neurologic disorder. Secondary RLS includes pregnancy and iron deficiency. Prevalence of RLS in pregnancy ranges from 11% to 27%. We aimed to assess the frequency and characteristics of RLS in pregnancy in a Peruvian population and to evaluate the possible pregnancy or delivery complications due to RLS. METHODS: We assessed 218 consecutive expectant mothers at the inpatient clinic of the Hospital San Bartolome in Lima, Peru. Assessment was performed by using the standard diagnostic criteria for RLS and by using a clinical and diagnostic interview. Questionnaires for RLS severity, idiopathic RLS (IRLS), and excessive daytime sleepiness (EDS) according to the Epworth sleepiness scale (ESS) were used. Blood examination was performed for hemoglobin and hematocrit. For comparison, RLS patients were matched for age and body mass index (BMI) with pregnant women without RLS. RESULTS: Out of 218 patients, 40 (18.4%) fulfilled diagnostic criteria for RLS. In RLS patients, prophylactic iron supplementation therapy during pregnancy was less frequently taken (P=.02). Pregnant women with RLS had a higher ESS score than pregnant controls (10.6 +/-3.1 vs 7.6. +/-3.6; P<.001). Preeclampsia was more frequent in RLS (7/40 vs 1/39; P=.03). CONCLUSIONS: In our study, RLS was frequent in pregnant Peruvian women, especially in those without prophylactic iron supplementation. RLS patients described more EDS. Preeclampsia was more common in RLS. Our study is the first study to indicate a possible association between RLS and preeclampsia. Restless legs syndrome (RLS) is a common neurological disorder. Secondary RLS includes pregnancy and iron deficiency. Prevalence of RLS in pregnancy ranges between 11-27%. We aimed at assessing frequency and characteristics of RLS in pregnancy in a Peruvian population and to evaluate possible pregnancy or delivery complications due to RLS. Methods:We assessed 218 consecutive expectant mothers at the inpatient clinic of the Hospital San Bartolome, Lima, Peru. Assessment was performed by using the standard diagnostic criteria for RLS and by a clinical-diagnostic interview. Questionnaires for RLS severity (IRLS) and excessive daytime sleepiness (EDS) by Epworth Sleepiness Scale (ESS) were used. Blood examination was performed for hemoglobin and hematocrit. For comparison, RLS patients were matched for age-and BMI with pregnant women without RLS. Results:Out of 218 patients, 40 (18.4%) fulfilled diagnostic criteria for RLS. In RLS patients, prophylactic iron supplementation therapy during pregnancy was taken less frequently (p=0.02). Pregnant women with RLS had a higher ESS score than pregnant controls (10.6 +/-3.1 vs. 7.6. +/-3.6; p<0.001). Preeclampsia was more frequent in RLS (7/40 vs. 1/39; p=0.03). Conclusions:In our study, RLS was frequent in pregnant Peruvian women, especially in those without prophylactic iron supplementation. RLS patients described more daytime sleepiness.Preeclampsia was more common in RLS. This is the first study indic...

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Iron status parameters in preeclamptic women

Abstract: We recommend that any pregnant female with higher serum iron and ferritin concentrations should be further investigated for preeclampsia.

Cited by 48 publications

References 30 publications

A Dormant Microbial Component in the Development of Preeclampsia

A Dormant Microbial Component in the Development of Preeclampsia

Iron Status in Pre-Eclampsia: A Case-Comparison Study

Is preeclampsia associated with restless legs syndrome?

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