Iron Status in Pre-Eclampsia: A Case-Comparison Study

Abstract

Preeclampsia is one of the most leading causes of maternal mortality in developing countries. Many studies have demonstrated the relation between alteration of iron status and preeclampsia. The aim of the study was to assess the status of iron in preeclampsia. This case control study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in the third trimester of pregnancy attending the Obstetrics & Gynaecology Department of Dhaka Medical College Hospital were selected purposively as study subjects. Among them 50 diagnosed cases of preeclampsia were selected as cases and 50 normal healthy pregnant women as controls. Serum ferritin and serum iron concentration were measured in all study subjects. The mean serum ferritin concentration in cases and controls were 95.06±50.07 µg/l and 45.56±27.44 µg/l respectively. Mean serum iron concentration in cases was 121.78±41.93 µg/dl and that in controls was 61.04±24.18 µg/dl. The present study showed significant differences of mean serum ferritin and serum iron between cases and controls. The study revealed presence of significantly higher level of serum ferritin and serum iron in preeclamptic group.

Iron status parameters in preeclamptic women in Gaza, Palestine

“…There are many hypotheses has been suggested to explain its etiology. Many researchers reported that alteration of iron status is a risk factor for the pathogenesis of preeclampsia (Sultana, et al, 2012;Masti, & Pharm, 2014). Excess iron is postulated as causal factor in the oxidative stress in its radical form, which might be involved in the pathogenesis of preeclampsia (Masti, & Pharm, 2014).…”

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“…Kadar zat besi bebas dalam jumlah yang berlebihan memiliki toksisitas yang tinggi terhadap sel. 5 Toksisitasnya berasal dari kecenderungannya menghasilkan radikal bebas yang menyebabkan kerusakan sel. Kadar zat besi yang berlebihan juga dikaitkan dengan peningkatan stres oksidatif dan disfungsi endotel, yang merupakan patogenesis utama terjadinya preeklampsia.…”

“…Zat besi dilepaskan dari plasenta iskemik akibat destruksi eritrosit, sehingga memicu proses peroksidasi lipid dan stres oksidatif yang menyebabkan disfungsi sel endotel pada preeklampsia. 6 Mekanisme perbaikan vaskular yang buruk disertai dengan vasospasme akan berkembang menjadi disfungsi endotel.…”

“…Proses hemolisis yang terjadi pada preeklampsia, akan meningkatkan kadar zat besi yang bebas, yang kemudian akan semakin memperberat derajat disfungsi endotel dan terbentuknya stres oksidatif, sehingga pada ujungnya akan memperberat manifestasi klinisi pada preeklampsia. 6,7 Hal ini menyebabkan terjadinya lingkaran setan terkait gangguan metabolisme zat besi dan preeklampsia. Peningkatan kadar zat besi dapat memperkuat patogenesa preeklampsia yang akan menghasilkan lebih banyak zat besi bebas.…”

Association of Maternal Serum Homocysteine Levels with Pre-eclampsia

“…2 Pre-eclampsia or eclampsia is decreasing in developed countries, but it is still a major cause of maternal death in developing countries like Bangladesh, where about 16% incidence of preeclampsia was reported. 3 It is due to lack of public awareness, inadequate health education, poor socio-economic condition and less antenatal coverage. It would be better to diagnose preeclampsia before clinical manifestation as prevention or delay in the onset of this disease would have a significant impact on maternal and perinatal outcome.…”