Iron status in 268 Danish women aged 18-30 years: influence of menstruation, contraceptive method, and iron supplementation

Milman, Nils; Clausen, Jens; Byg, Keld-Erik

doi:10.1007/s002770050405

Cited by 125 publications

(98 citation statements)

References 22 publications

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“…We found that women without contraception had a higher elimination of iron, which led to steady-state concentrations of iron lower by about 20% compared to women using contraception. It has been shown that contraception regulates the abundance of menses (34) and therefore limits iron loss (35), which can explain this finding. Iron concentrations at steady-state were also affected by body size, as we found that iron absorption decreased when the body mass index increased.…”

Section: Discussionmentioning

confidence: 82%

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Angeli

Lainé

Lavenu

et al. 2016

AAPS J

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Abstract. Hepcidin regulates serum iron levels, and its dosage is used in differential diagnostic of iron-related pathologies. We used the data collected in the HEPMEN (named after HEPcidin during MENses) study to investigate the joint dynamics of serum hepcidin and iron during the menstrual cycle in healthy women. Ninety menstruating women were recruited after a screening visit. Six fasting blood samples for determination of iron-status variables were taken in the morning throughout the cycle, starting on the second day of the period. Non-linear mixed effect models were used to describe the evolution of iron and hepcidin.Demographic and medical covariates were tested for their effect on model parameters. Parameter estimation was performed using the SAEM algorithm implemented in the Monolix software. A general pattern was observed for both hepcidin and iron, consisting of an initial decrease during menstruation, followed by a rebound and stabilising during the second half of the cycle. We developed a joint model including a menstruation-induced decrease of both molecules at the beginning of the menses and a rebound effect after menses. Iron stimulated the release of hepcidin. Several covariates, including contraception, amount of blood loss and ferritin, were found to influence the parameters. The joint model of iron and hepcidin was able to describe the fluctuations induced by blood loss from menstruation in healthy non-menopausal women and the subsequent regulation. The HEPMEN study showed fluctuations of iron-status variables during the menstrual cycle, which should be considered when using hepcidin measurements for diagnostic purposes in women of child-bearing potential.

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Section: Discussionmentioning

confidence: 82%

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Angeli

Lainé

Lavenu

et al. 2016

AAPS J

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“…Due to the regular blood and iron losses at their menstrual periods, women of reproductive age a priori face a difficult situation concerning their iron balance. The amount of iron lost by menstruation varies from woman to woman, but is quite constant in the individual women [24]. Natural mechanisms in women have not compensated for these iron losses.…”

Section: Women Of Reproductive Agementioning

confidence: 99%

“…The lowest prevalence ~25% is found in Europe and the Americas, whereas South-East Asia and Africa present high prevalences of 48% and 57%, respectively [3]. In Denmark, pregnant women who do not take iron supplements have a prevalence of anemia of ~25% [24]; in contrast, the prevalence of anemia in women taking 40 mg ferrous iron daily is below 5% [25].…”

Section: Pregnant Womenmentioning

confidence: 99%

Anemia—still a major health problem in many parts of the world!

2011

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Anemia is a major global health problem, especially in developing countries. Still this fundamental health issue has not been solved but continues to exist affecting the health, quality of life and working capacity in billions of people all over the world. This paper gives a review on the prevalence and major causes of anemia seen on a global scale. Most cases of anemia are due to iron deficiency, which often work in symphony with folate deficiency and/or vitamin B 12 deficiency as well as with infections. More efforts should be dedicated to tackle this massive problem -we have the tools and we know the ways. Iron fortification of appropriate food items combined with iron supplements in specific population groups has proved to be efficient. Initially, the efforts should be centered on the specific risk groups for iron deficiency anemia, i.e. young children, adolescent females, women of reproductive age as well as pregnant women and postpartum lactating mothers.

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“…[13][14][15] It is projected that India has the utmost prevalence of anemia, i.e., 57-96.2%, among the South Asian countries. [16][17][18] To combat the high prevalence of IDA several government programs and state level schemes were rolled out in various states of India.…”

Section: Past Efforts and Current Scenariomentioning

confidence: 99%

Does effective counseling play an important role in controlling iron deficiency anemia among pregnant women

Saha¹,

Mazumder²,

Samanta³

2018

Natl J Physiol Pharm Pharmacol

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Background: Anemia during pregnancy is a common problem in most developing countries. According to the World Health Organization (1968), iron deficiency anemia (IDA) was present in 40-99% of pregnant women. Although many government projects have been introduced to eliminate this public health menace, non-compliance of iron and folic acid (IFA) supplementation due to various reasons made the projects unsuccessful. Hence, it is time to reexamine the problem of anemia in pregnancy, to assess more carefully the local etiological factors for prevailing and responsible for IDA, and then to design new strategies for prevention of the same. Aims and Objectives: The main of this study is to provide counseling to IDA pregnant women by effective communication and to study the impact of counseling on hematological indices. Materials and Methods: Pregnant women of rural population were first screened for IDA and then IDA women were grouped into experimental and control group. The experimental group women received counseling regarding benefits of regular IFA supplementation and good hygiene practices while the women in the control group were devoid of such counseling. Data on hematological parameters, hygiene practices, and IFA supplementation were taken from both groups and also after the end of the study. Data were then analyzed for statistical significance. Results: Our study showed statistically significant improvement in anemic status among pregnant women of the experimental group. Conclusion: In our study, it can be concluded that community-based interventions by means of effective communication help in improving anemic status in pregnant women.

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Iron status in 268 Danish women aged 18-30 years: influence of menstruation, contraceptive method, and iron supplementation

Cited by 125 publications

References 22 publications

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Anemia—still a major health problem in many parts of the world!

Does effective counseling play an important role in controlling iron deficiency anemia among pregnant women

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