Iron status and haematological changes in adolescent female inpatients with anorexia nervosa

Kennedy, Amy; Kohn, Michael; Lammi, Ahti; Clarke, Stephen

doi:10.1111/j.1440-1754.2004.00432.x

Cited by 53 publications

(60 citation statements)

References 2 publications

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“…Iron deficiency is uncommon among female patients with anorexia nervosa due to increased iron storage secondary to reduced iron losses from amenorrhoea 17 . However, low body mass index (BMI) was an independent risk factor for 'mild iron deficiency' (serum ferritin , 20 mg l 21 and haemoglobin $120 g l…”

mentioning

confidence: 99%

Trends in the prevalence of anaemia in Japanese adult women, 1989–2003

Hayashi

Yoshiike

Yoshita

et al. 2008

Public Health Nutr.

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Objective: There is an increasing concern of anaemia in Japanese women, but no national trend data has existed to date. We analysed long-term national trends of anaemia in adult women. Design: Secondary analyses of 15 consecutive cross-sectional nationwide surveys conducted during the period 1989-2003. Analyses were based on 5-year intervals (1989-1993, 1994-1998, 1999-2003). Setting: Japan. Subjects: The subjects included the National Health and Nutrition Survey of Japan (NHNS-J) population. Analyses were based on 50 967 non-pregnant/non-lactating women aged 20 years and over, with complete data sets. We stratified subjects into six age groups (20-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years and 701 years), and three age groups (20-49 years, 50-69 years, 701 years) for analyses on residential areas (metropolitan, cities and towns). Results: Decreases in trends of mean haemoglobin values (intravenous) were significant in all age groups. Changes in the prevalence of anaemia were significant only in women aged 30-39 and 40-49 years. Anaemia (haemoglobin , 12.0 g dl 21 ) increased from 16.8% to 20.6% in women aged 30-39 years, and from 20.2% to 26.9% in women aged 40-49 years, respectively. Prevalence was highest in women aged 70 years and older in all times, but no significant change was observed. Conclusions: Haemoglobin values have declined significantly in all ages in the last 15 years. Anaemia was especially significant in women aged 30-39 years and 40-49 years. Our findings suggest that a large number of young women in Japan are at risk of anaemia, so continuous monitoring and controlling efforts of this trend are needed.

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mentioning

confidence: 99%

Trends in the prevalence of anaemia in Japanese adult women, 1989–2003

Hayashi

Yoshiike

Yoshita

et al. 2008

Public Health Nutr.

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“…A normal C-reactive protein can be used to exclude elevated ferritin caused by acute phase reactions. According to a study of anorexia nervosa patients, ferritin can be elevated during periods of acute malnourishment, perhaps due to iron going into storage as intravascular volume and thus the number of red blood cells falls [24]. Erhabor Recent study suggests that due to the catabolic nature of anorexia nervosa, isoferritins may be released.…”

Section: High Serum Ferritinmentioning

confidence: 99%

Ferritin Level in Pre and Postmenopausal Women Attending Usmanu Danfodiyo University Teaching Hospital Sokoto

Erhabor¹

2017

HIJ

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Healthy individuals possess 3-4g of iron in his/her iron store, mostly in haemoglobin (oxygen-carrying pigment of blood) which is the most essential requirement of blood. Ferritin is a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion. Serum ferritin is an indirect marker of the total amount of iron stored in the body and hence is used as a diagnostic marker for iron deficiency anaemia. This study was carried out to determine the level of serum ferritin in pre-and postmenopausal women attending Usmanu Danfodiyo University Teaching Hospital Sokoto. The study was conducted among one hundred and fifty women (75 premenopausal and 75 postmenopausal) with mean age 43.99±19.22. The age range for premenopausal and postmenopausal women was 18-49 and 50-87 years respectively. The serum ferritin levels were compared among the premenopausal and postmenopausal subjects. The serum ferritin was significantly higher among postmenopausal women 47.38 ± 43.00 compared to premenopausal women 21.96 ± 20.15 (p=0.01). The prevalence of anaemia based on serum ferritin level was higher among premenopausal women (8.7%) compared to postmenopausal women (2.7%). Low ferritin level <3.5ng/ml was higher among Hausa /Fulani (6.02%) compared to other ethnic groups. The difference however was not statistically significant (p=0.91). Low ferritin level was higher among premenopausal women in the 25-34 years age group compared to other age groups. This study has shown that anaemia based on serum ferritin level of <3.5ng/ml was significantly higher among premenopausal compared to postmenopausal women. Ferritin level <3.5ng/ml was higher among Hausa /Fulani (6.02%) and among premenopausal women in the 25-34 years age group. Serum ferritin should be used for the diagnosis and monitoring of iron deficiency anaemia in pre-and postmenopausal women. Ferritin level of <3.5ng/ml should be used as cutoff for the diagnosis of depleted iron store.

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“…Serum C-reactive protein (CRP) was negative in all of the samples (CRP < 6 mg/L). A normal CRP is necessary to ensure that no inflammation affects serum ferritin or hepcidin [11].…”

Section: Patientsmentioning

confidence: 99%

Correlation of Hepcidin Level with Insulin Resistance and Endocrine Glands Function in Major Thalassemia

Al‐Hakeim¹,

Al-Khakani²,

Al-Kindi³

2015

Adv Clin Exp Med

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Background. Hepcidin is a master regulator of iron metabolism that inhibits the transport of iron out of enterocytes and macrophages. Thalassemia major (TM) is associated with some of the endocrine disorders. However, studies have yet to be conducted on the correlation of hepcidin with hormone levels and insulin resistance (IR) in patients with TM. Objectives. In the present study, the correlation of hepcidin level with some endocrine and biochemical parameters was investigated to determine the factors that mainly affect hepcidin correlation in patients with thalassemia. These factors include hormones, iron status, and IR parameters. Material and Methods. Hepcidin and other measured biochemical parameters were compared between the TM patients (100) and healthy children (37). Results. Serum thyroid-stimulating hormone (TSH) was positively correlated (p < 0.05) with hepcidin, iron, and ferritin. T4 hormone was correlated with ferritin only. Other hormones showed different correlation patterns with iron status parameters but were statistically insignificant (p > 0.05). The percentage of β-cell function was the only parameter among the IR parameters that showed a significant difference between thalassemic and control groups. Conclusions. Thyroid and β-cells dysfunctions are common in TM patients with frequent blood transfusions. In addition, hepcidin and TSH levels can be predicted significantly using the most correlated factors with hepcidin. These factors, including ferritin, insulin and TSH were used to construct predicting equations: S. Hepcidin = = 0.003*Ferritin + 3.02*TSH + 0.12*Insulin + 16.85 (± 7.78) and TSH = 0.0083 × Insulin + 0.0042 × Ferritin + + 0.0937 × Hepcidin + 1.91 (± 1.373) (Adv Clin Exp Med 2015, 24, 1, 69-78).

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Iron status and haematological changes in adolescent female inpatients with anorexia nervosa

Cited by 53 publications

References 2 publications

Trends in the prevalence of anaemia in Japanese adult women, 1989–2003

Trends in the prevalence of anaemia in Japanese adult women, 1989–2003

Ferritin Level in Pre and Postmenopausal Women Attending Usmanu Danfodiyo University Teaching Hospital Sokoto

Correlation of Hepcidin Level with Insulin Resistance and Endocrine Glands Function in Major Thalassemia

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