Correlation of Hepcidin Level with Insulin Resistance
and Endocrine Glands Function in Major Thalassemia

Al‐Hakeim, Hussein Kadhem; Al-Khakani, Manal M.; Al-Kindi, Mahmood A.

doi:10.17219/acem/38158

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…Al-Hakeim et al compared the results of thyroid function tests and markers of Fe haemostasis in children with thalassemia. They noted significantly positive correlation between TSH and hepcidin, ferritin, and Fe concentration [34]. In the study by Czarnywojtek et al, a significant positive correlation between TSH and RDW was noted in hypothyroid patients [13].…”

Section: Discussionmentioning

confidence: 99%

Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects

Hernik

Szczepanek‐Parulska

Filipowicz

et al. 2019

Mediators of Inflammation

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Purpose. Hepcidin is an acute-phase protein involved also in regulation of iron homeostasis. The aim of the study was to prospectively assess for the first time the hepcidinEL concentration in patients with subacute thyroiditis (SAT), to identify biochemical determinants of hepcidinEL concentration and evaluate the potential role of hepcidin in SAT diagnosis and monitoring. Methods. Out of 40 patients with SAT initially recruited, restrictive inclusion criteria fulfilled 21 subjects aged 45±10 years and 21 healthy control subjects (CS). HepcidinEL concentration, thyroid status, and iron homeostasis were evaluated at SAT diagnosis and following therapy and compared with CS. Results. The median hepcidinEL concentration at SAT diagnosis is higher than that in CS (48.8 (15.9-74.5) ng/mL vs. 18.2 (10.2-23.3) ng/mL, p=0.009) and is significantly lower after treatment (4.0 (1.2-10.0) ng/mL, p=0.007) compared with CS. The ROC analysis for hepcidinEL at SAT diagnosis revealed that area under the curve (AUC) is 0.735 (p=0.009), and the cut-off for hepcidinEL concentration is 48.8 ng/mL (sensitivity 0.52 and specificity 0.95). HepcidinEL in SAT patients correlated with CRP (r=0.614, p=0.003), ferritin (r=0.815, p<0.001), and aTPO (r = -0.491, p=0.024). On multiple regression, the correlation between hepcidinEL and ferritin was confirmed (p<0.001). Conclusions. SAT is accompanied by a significant increase in hepcidin, which reflects an acute-phase inflammatory process. Parameters of iron homeostasis improved significantly while inflammatory indices got lower following recovery. The potential role of hepcidin as a predictive factor of the risk of SAT relapse needs to be assessed in studies on larger groups of SAT patients.

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Section: Discussionmentioning

confidence: 99%

Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects

Hernik

Szczepanek‐Parulska

Filipowicz

et al. 2019

Mediators of Inflammation

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“…This has recently been studied in relation to thyroid function (although outside pregnancy) and the authors found a positive correlation between both parameters (32). This might imply that SCH leads to higher levels of hepcidin, the latter then blocking iron absorption.…”

Section: :3mentioning

confidence: 95%

Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?

Veltri¹,

Decaillet²,

Kleynen³

et al. 2016

European Journal of Endocrinology

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Objective: Thyroid disorders and iron deficiency (ID) are associated with obstetrical and fetal complications. Iron is essential for the normal functioning of thyroid peroxidase (TPO-abs) and ID is frequent during pregnancy. The aim of this study was to compare the prevalence of thyroid autoimmunity (TAI) and dysfunction during the first trimester of pregnancy in women with and without ID. Design: Cross-sectional data analysis of 1900 pregnant women nested within an ongoing prospective collection of pregnant women's data. Method: The study was performed in a single, tertiary referral center. During the first antenatal visit, ferritin, TPO-abs, thyroid-stimulating hormone (TSH) and free T 4 (FT 4 ) were measured and age and BMI were recorded. ID was defined as ferritin <15 µg/L, TAI when TPO-abs was >60 kIU/L, and subclinical hypothyroidism (SCH) when TSH was >2.5 mIU/L. Results: ID was present in 35% of women. Age and BMI were comparable between both groups. In the ID group, the prevalence of TAI and SCH was significantly higher, compared with that in the non-ID group (10% vs 6% and 20% vs 16%; P = 0.011 and 0.049 respectively). Ferritin was inversely correlated with serum TSH (ρ = −0.076; P = 0.001) and positive with FT 4 levels (ρ = 0.112; P < 0.001). In the logistic regression model, ID remained associated with TAI after correction for confounding factors (P = 0.017). The association with SCH was absent after correction for the confounders in the logistic regression model (P = 0.082), but remained present in the linear regression model (P = 0.035). Conclusions: ID was frequent during the first trimester of pregnancy and was associated with a higher prevalence of TAI, higher serum TSH, and lower FT 4 levels.

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“…Most of these patients are born in developing and low-income countries, specially; individuals originate from Mediterranean, Middle East, Asian subcontinent and Southeast Asia (Weatherall and Clegg, 2001;Cao and Kan,2013). Thalassemia has been studied in various cities and different fields in Iraq (Al-Samarrai et al, 2008;Abdulzahraa et al, 2011;Al-Hakeim et al, 2015). β-Thalassaemia major is a type of chronic, inherited and microcytic anaemia that is characterized by impaired biosynthesis of the β-globin chain of haemoglobin that lead to accumulation of unpaired α-globin chain.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of the Endocrine Disorders of Βeta-Thalassemia Major Patients and Control Group in Duhok Province

Ali

Jubrial

Najeeb

2018

SJUOZ

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Beta- thalassemia major is a type of inherited blood disorder, characterized by impaired synthesis of the beta chains. Currently, blood transfusion and sufficient iron chelation therapy are important for treatment and follow up of thalassemia patients. Unfortunately, repeated blood transfusion causes the progressive iron overload. Consequently, the excess iron is deposited as hemosiderin and ferritin in the tissues and multiple endocrine complications. In comparison with healthy control group, the results indicated significant (p<0.05) increased TSH level (3.86 ± 2.7 1µIU/ml), whereas the serum level of T4 hormone did not significantly differ between the two groups. In the thalassemia patients, 23.68% (9/38) had subclinical hypothyroidism. The mean level of estradiol in patients (30.60± 14.68pg/ml) is high significant (p< 0.01) decreased that compared with the control persons (13.83 ± 9.06 pg/ml) more than 13 years. Testosterone level in patients was significantly different (P< 0.001) respectively from the control group. The mean of testosterone level was 1.22± 0.83 ng/ml in thalassemia patients and 3.71± 1.32ng/ml in control group more than 14 years. These results indicate high prevalence hypothyroidism and puberty defection. Endocrine drugs supplementation is a safe for patients which have each type of endocrine disorders.

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Correlation of Hepcidin Level with Insulin Resistance and Endocrine Glands Function in Major Thalassemia

Cited by 11 publications

References 27 publications

Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects

Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects

Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?

Comparative Study of the Endocrine Disorders of Βeta-Thalassemia Major Patients and Control Group in Duhok Province

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