“…In S. cerevisiae, the Aft1 and Aft2 transcription factors promote the transcriptional activation of genes encoding proteins that participate in extracellular Fe acquisition, Fe mobilization and recycling, and metabolic remodeling when Fe bioavailability is low (15)(16)(17). Furthermore, during Fe deficiency, a decrease in the levels of some Fe-dependent metabolites, including heme and ␣-isopropylmalate, leads to downregulation in the transcription of genes that function in respiration and leucine synthesis, respectively (33). In addition to this transcriptional regulation mediated by Fe-responsive metabolites, the metabolic reprogramming observed in response to low Fe is also posttranscriptionally controlled by the mRNA-binding proteins Cth1 and Cth2 (19,20).…”