Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

Said, Noresah; Abidin, Muhammad Nidzhom Zainol; Hasbullah, Hasrinah; Ismail, Ahmad Fauzi; Goh, Pei Sean; Othman, Mohd Hafiz Dzarfan; Abdullah, Mohd Sohaimi; Ng, Be Cheer; Kadir, Siti Hamimah Sheikh Abdul; Kamal, Fatmawati

doi:10.1002/app.48234

Cited by 16 publications

(7 citation statements)

References 63 publications

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“…Membrane processes are classified based on their operational driving forces, which further depend on their separation mechanisms, such as sieving [ 38 ], solution-diffusion [ 39 ], adsorption [ 40 ], and electrochemical effects [ 41 ]. Thus, the driving forces include the gradients of pressure [ 42 , 43 , 44 , 45 ], potential [ 46 , 47 , 48 ], and concentration [ 49 , 50 ] across the membrane. Pressure driven membrane processes include MF [ 51 ], UF [ 52 ], NF [ 53 ], and RO [ 54 ].…”

Section: Membrane Processes Based On Various Separation Driving Forcesmentioning

confidence: 99%

Fouling Prevention in Polymeric Membranes by Radiation Induced Graft Copolymerization

2022

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The application of membrane processes in various fields has now undergone accelerated developments, despite the presence of some hurdles impacting the process efficiency. Fouling is arguably the main hindrance for a wider implementation of polymeric membranes, particularly in pressure-driven membrane processes, causing higher costs of energy, operation, and maintenance. Radiation induced graft copolymerization (RIGC) is a powerful versatile technique for covalently imparting selected chemical functionalities to membrane surfaces, providing a potential solution to fouling problems. This article aims to systematically review the progress in modifications of polymeric membranes by RIGC of polar monomers onto membranes using various low- and high-energy radiation sources (UV, plasma, γ-rays, and electron beam) for fouling prevention. The feasibility of the modification method with respect to physico-chemical and antifouling properties of the membrane is discussed. Furthermore, the major challenges to the modified membranes in terms of sustainability are outlined and the future research directions are also highlighted. It is expected that this review would attract the attention of membrane developers, users, researchers, and scientists to appreciate the merits of using RIGC for modifying polymeric membranes to mitigate the fouling issue, increase membrane lifespan, and enhance the membrane system efficiency.

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Section: Membrane Processes Based On Various Separation Driving Forcesmentioning

confidence: 99%

Fouling Prevention in Polymeric Membranes by Radiation Induced Graft Copolymerization

2022

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“…Said et al [ 112 ] reported the obtaining of polysulfone membrane functionalized with iron oxide for better biocompatibility and being able to remove the middle molecule uremic toxin effectively. It was shown that even though a high concentration of iron oxide was added, it displayed a reduction of protein adsorption and platelet adhesion while maintaining normal blood coagulation time and admissible complement activation [ 112 ]. Unfortunately, iron oxide nanoparticles have a tendency to form aggregates.…”

Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Radu

Voicu

2022

Polymers

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The field of membrane materials is one of the most dynamic due to the continuously changing requirements regarding the selectivity and the upgradation of the materials developed with the constantly changing needs. Two membrane processes are essential at present, not for development, but for everyday life—desalination and hemodialysis. Hemodialysis has preserved life and increased life expectancy over the past 60–70 years for tens of millions of people with chronic kidney dysfunction. In addition to the challenges related to the efficiency and separative properties of the membranes, the biggest challenge remained and still remains the assurance of hemocompatibility—not affecting the blood during its recirculation outside the body for 4 h once every two days. This review presents the latest research carried out in the field of functionalization of polysulfone membranes (the most used polymer in the preparation of membranes for hemodialysis) with the purpose of increasing the hemocompatibility and efficiency of the separation process itself with a decreasing impact on the body.

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“…Iron oxide nanoparticle (Fe 2 O 3 NP) is another alternative additive. Said et al developed membranes made up of polysulfone and Fe 2 O 3 NPs, and found that these membranes have improved biocompatibility and excellent clearance of urea and lysozyme [ 122 ].…”

Section: The Toxicity Of Biomaterials For Blood Purificationmentioning

confidence: 99%

Recent trends in therapeutic application of engineered blood purification materials for kidney disease

et al. 2022

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Blood purification is a commonly used method to remove excess metabolic waste in the blood in renal replacement therapy. The sufficient removal of these toxins from blood can reduce complications and improve survival lifetime in dialysis patients. However, the current biological blood purification materials in clinical practice are not ideal, where there is an unmet need for producing novel materials that have better biocompatibility, reduced toxicity, and, in particular, more efficient toxin clearance rates and a lower cost of production. Given this, this review has carefully summarized newly developed engineered different structural biomedical materials for blood purification in terms of types and structure characteristics of blood purification materials, the production process, as well as interfacial chemical adsorption properties or mechanisms. This study may provide a valuable reference for fabricating a user-friendly purification device that is more suitable for clinical blood purification applications in dialysis patients. Graphical Abstract

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Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

Cited by 16 publications

References 63 publications

Fouling Prevention in Polymeric Membranes by Radiation Induced Graft Copolymerization

Fouling Prevention in Polymeric Membranes by Radiation Induced Graft Copolymerization

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Recent trends in therapeutic application of engineered blood purification materials for kidney disease

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