Iron oxide nanoparticle surface decorated with cRGD peptides for magnetic resonance imaging of brain tumors

Richard, Sophie; Boucher, Marianne; Lalatonne, Yoann; Mériaux, Sébastien; Motte, Laurence

doi:10.1016/j.bbagen.2016.12.020

Cited by 46 publications

(38 citation statements)

References 33 publications

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“…Thus, considering the surface area of the phosphonate group (0.24 nm 2 ) and the molecular polymer weight ( M W = 2100 g mol −1 ), the corresponding Flory radius found equal to 3.4 nm . The distance D is inferior to R F suggesting a brush conformation after PEG grafting onto the NP surface . After the coating process, the magnetization saturation (Ms = 49 emu g −1 , Figure G) remained similar while the blocking temperature decreased ( T b = 100 K, Figure I) compared to bare NPs (Figure S1, Supporting Information).…”

Section: Resultsmentioning

confidence: 94%

“…The o ‐phthalaldehyde (OPA) method was used for quantification of amino groups after chemical decomposition of the amide coupling on NPs (see Figure S8, Supporting Information) . An average of 4.3 ± 0.3 proteins per NP was found, corresponding to a yield of 50%.…”

Section: Resultsmentioning

confidence: 99%

“…Due to finite size effects, such as the high surface‐to‐volume ratio, USPIO have unique features for drug loading and drug delivery in various vascular pathologies including notably enhanced permeability and retention (EPR) effect . In addition USPIO present convenient surface reactivity, allowing NP surface functionalization with therapeutics and/or targeting molecules . Besides USPIO currently appear to be a relevant MRI contrast agent .…”

Section: Introductionmentioning

confidence: 99%

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Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice

Dubreil

Catherine

Lalatonne

et al. 2018

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Nanoparticle (NP) administration is among the most attractive approaches to exploit the synergy of different copackaged molecules for the same target. In this work, iron oxide NPs are surface-engineered for the copackaging of the autoantigen proinsulin, a major target of adaptive immunity in type 1 diabetes (T1D), and 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methylester (ITE), a small drug conditioning a tolerogenic environment. Magnetic resonance imaging (MRI) combined with magnetic quantification are used to investigate NP biokinetics in nonobese diabetic (NOD) mice and control mice in different organs. Different NP biodistribution, with in particular enhanced kidney elimination and a stronger accumulation in the pancreas for prediabetic NOD mice, is observed. This is related to preferential NP accumulation in the pancreatic inflammatory zone and to enhancement of renal elimination by diabetic nephropathy. For both mouse strains, an MRI T2 contrast enhancement at 72 h in the liver, pancreas, and kidneys, and indicating recirculating NPs, is also found. This unexpected result is confirmed by magnetic quantification at different time points as well as by histological evaluation. Besides, such NPs are potential MRI contrast agents for early diagnosis of T1D.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice

Dubreil

Catherine

Lalatonne

et al. 2018

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“…The excellent microbial property of iron has resulted in its use in several applications including diaper rashes and allergic diaper rashes, creams for skin blisters, and antiseptic powders . Studies reveal the application of iron nanoparticles (FeNPs) functionalized with phosphonate polyethylene glycol and coupled to the cyclo RGD peptide sequence as magnetic resonance imaging contrast agents due to their magnetic activities . Besides, by coating the FeNPs with albumin, conjugating the tumor‐specific ligand folic acid onto them, and labeling with fluorescein isothiocyanate, an increased intracellular dual‐modal imaging, specifically the magnetic resonance imaging and intracellular visualization, for brain tumors can be obtained .…”

Section: Introductionmentioning

confidence: 99%

Suppressor capacity of iron nanoparticles biosynthesized using Salvia chloroleuca leaf aqueous extract on methadone‐induced cell death in PC12: Formulation a new drug from relationship between the nanobiotechnology and neurology sciences

Ahmeda

Zangeneh

Mansooridara

et al. 2020

Applied Organom Chemis

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Metallic nanoparticles have gained significant attention in the area of biomedical technology. Because of its high surface area, metallic nanoparticles are being widely used in various fields including the medical and engineering sciences. One of the valuable applications of metallic nanoparticles especially copper, zinc, and iron nanoparticles is increasing the physiological function of central nervous system. Besides, Iranian people are using the Salvia chloroleuca for neuroprotective properties. In the present research, iron nanoparticles were biosynthesized by S. chloroleuca leaf aqueous extract as reducing and stabilizing agents. Also, we revealed the protective effect of FeNPs in methadone‐treated PC12 cells. FeNPs were characterized and analyzed using common nanotechnology techniques including FT‐IR, UV–Vis. spectroscopy; EDS, TEM, and FE‐SEM. TEM and FE‐SEM images revealed a uniform spherical morphology for FeNPs. In the biological part of the current study, the both treatments of FeNPs significantly (p ≤ 0.01) reduced the cell cytotoxicity and cell death index as well as increased the cell viability and cell proliferation in methadone‐treated PC12 cells. In these treatments, mitochondrial membrane potential significantly (p ≤ 0.01) increased compared to methadone‐induced PC12 cells. DPPH free radical scavenging test was did to evaluate the antioxidant potentials of FeCl3, S. chloroleuca, and FeNPs. DPPH test indicated similar antioxidant activities for S. chloroleuca, FeNPs, and butylated hydroxytoluene. In current experiment, we concluded that iron nanoparticles biosynthesized by S. chloroleuca leaf aqueous extract suppressed methadone‐induced cell death in a dose‐dependent manner in PC12 cells.

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) have received great interest in various biological applications, such as targeted drug delivery, biosensors, molecular and cellular imaging, hyperthermia, and regenerative medicine . The healing effect of the magnetic field on tissues, such as on bones, nerves, and muscle have been known for many years.…”

Section: Introductionmentioning

confidence: 99%

Magnetic silk fibroin composite nanofibers for biomedical applications: Fabrication and evaluation of the chemical, thermal, mechanical, and in vitro biological properties

Lalegül‐Ülker

Vurat

Elçin

et al. 2019

J of Applied Polymer Sci

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Magnetically responsive polymer composites have great potential for use in diverse biomedical applications. In this study, composite biomaterials consisting of silk fibroin (SF) and superparamagnetic iron oxide nanoparticles (SPIONs) were fabricated by the electrospinning method. Two different methods were employed to incorporate the SPIONs into the SF nanofibers. In the first encapsulation method (M1), SPIONs (1.0, 3.0, and 5.0 wt%) were initially included in the electrospinning solution. In the second dip-coating method (M2), electrospun SF nanofiber mats were immersed in the aqueous suspensions of SPIONs (10, 30 and 50% v/v). Then, the pure and composite silk fibroin composite mats were comparatively evaluated for their morphological, chemical, magnetic, mechanical and in vitro biological properties, by using a number of methods including SEM, TEM, FTIR, XRD, EDS, VSM, TGA, mechanical tensile tests, as well as by indirect in vitro cytotoxicity and in vitro hemocompatibility analyses. Overall findings suggested that, while M1 nanofiber mats could be a suitable candidate for use in tissue engineering as a magnetically responsive cytocompatible scaffold, the M2 nanofiber mats perhaps could be more appropriate as an interface for triggering the in vitro stem cell differentiation and/or biosensor applications.

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Iron oxide nanoparticle surface decorated with cRGD peptides for magnetic resonance imaging of brain tumors

Cited by 46 publications

References 33 publications

Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice

Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice

Suppressor capacity of iron nanoparticles biosynthesized using Salvia chloroleuca leaf aqueous extract on methadone‐induced cell death in PC12: Formulation a new drug from relationship between the nanobiotechnology and neurology sciences

Magnetic silk fibroin composite nanofibers for biomedical applications: Fabrication and evaluation of the chemical, thermal, mechanical, and in vitro biological properties

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