Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents

Wang, Xia; Niu, Dechao; Wu, Qing; Bao, Song; Su, Teng; Liu, Xiaohang; Zhang, Shengjian; Wang, Qigang

doi:10.1016/j.biomaterials.2015.02.101

Cited by 77 publications

(52 citation statements)

References 44 publications

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“…Manganese dioxide (MnO 2 ) is known to be stable under neutral and basic pH, but can be decomposed into Mn 2+ under reduced pH values 38 . Therefore, TEM images of H-MnO 2 -PEG after incubation in phosphate-buffered saline (PBS) with different pH values (7.4 and 5.5) for various treated time were recorded (Fig.…”

Section: Resultsmentioning

confidence: 99%

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

et al. 2017

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Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO2) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses. With hollow structures, H-MnO2 nanoshells post modification with polyethylene glycol (PEG) could be co-loaded with a photodynamic agent chlorine e6 (Ce6), and a chemotherapy drug doxorubicin (DOX). The obtained H-MnO2-PEG/C&D would be dissociated under reduced pH within TME to release loaded therapeutic molecules, and in the meantime induce decomposition of tumor endogenous H2O2 to relieve tumor hypoxia. As a result, a remarkable in vivo synergistic therapeutic effect is achieved through the combined chemo-photodynamic therapy, which simultaneously triggers a series of anti-tumor immune responses. Its further combination with checkpoint-blockade therapy would lead to inhibition of tumors at distant sites, promising for tumor metastasis treatment.

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Section: Resultsmentioning

confidence: 99%

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

et al. 2017

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“…Spin echo and gradient echo imaging sequences were used to obtain T1 and T2 weighted scans, images were exported as DICOM images, and ImageJ (NIH, Bethesda, MD) was used for processing. [20,25,29]…”

Section: Methodsmentioning

confidence: 99%

Shape memory polymers with enhanced visibility for magnetic resonance- and X-ray imaging modalities

et al. 2017

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Currently, monitoring of minimally invasive medical devices is performed using fluoroscopy. The risks associated with fluoroscopy, including increased risk of cancer, make this method especially unsuitable for pediatric device delivery and follow-up procedures. A more suitable method is magnetic resonance (MR) imaging, which makes use of harmless magnetic fields rather than ionizing radiation when imaging the patient; this method is safer for both the patient and the performing technicians. Unfortunately, there is a lack of research available on bulk polymeric materials to enhance MR-visibility for use in medical devices. Here we show the incorporation of both physical and chemical modifying agents for the enhancement of both MR and X-ray visibility. Through the incorporation of these additives, we are able to control shape recovery of the polymer without sacrificing the thermal transition temperatures or the mechanical properties. For long-term implantation, these MR-visible materials do not have altered degradation profiles, and the release of additives is well below significant thresholds for daily dosages of MR-visible compounds. We anticipate our materials to be a starting point for safer, MR-visible medical devices incorporating polymeric components.

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“…Alternatively, T 2 contrast agents commonly consist of superparamagnetic nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), and can be magnetically saturated by the typical magnetic field strengths in MRI scanners [2,10]. These agents work by shortening the traverse relaxation time (T 2 ) of water protons in their vicinity [11,12]. While they have high detection sensitivity for lesions, their magnetic susceptibility to artifacts and inherent negative (dark) contrast effects can induce low signal-to-noise ratios, which limits their application [13,14].…”

Section: Introductionmentioning

confidence: 98%

“…They can be activated under an intracellular reducing environment for ultrasensitive bimodal MR imaging in vivo. To date, various Mn-based materials, such as Mn chelates [27], MnO nanoparticles [28], and hybrid nanomaterials [11,29], have been applied for MR imaging with good biocompatibility. However, the application of a redoxable Mn 3 O 4 layer as the MGRS of a DMCA has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

et al. 2016

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Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents

Cited by 77 publications

References 44 publications

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Shape memory polymers with enhanced visibility for magnetic resonance- and X-ray imaging modalities

Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

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