Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

Kim, Myeong Hoon; Son, Ho‐Young; Kim, Ga Yun; Park, Kwangyeol; Huh, Yong Min; Haam, Seungjoo

doi:10.1016/j.biomaterials.2016.05.054

Cited by 59 publications

(62 citation statements)

References 37 publications

(53 reference statements)

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“…reported core–shell Fe 3 O 4 @Mn 3 O 4 NPs, where Mn 2+ ions released from the Mn 3 O 4 shell under reducing conditions allowed Fe 3 O 4 NPs to interact with water protons, thereby enhancing contrast of both T 1 and T 2 -weighted MRI. 207 By confining Mn 2+ within pH-sensitive calcium phosphate NPs (PEGMnCaP NPs, Fig. 20a), Mi et al .…”

Section: Strategies To Achieve High Relaxivity For Mri Contrast Enmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.

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Section: Strategies To Achieve High Relaxivity For Mri Contrast Enmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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“…[32,44] In general terms, the preparation of well-defined manganese oxidesn anostructures other than MnO 2 requires more complex approaches. For example, Hsu et al [44] reported the preparation of MnO NPs through the thermal decomposition of manganese(II)o leatea t2 80 8Cf or 1h.T hermal decomposition protocols are based on the controlled destruction of organometallic compounds in oxygen-and water-free atmosphere,r esulting in the slow availability of metal precursors, thus enabling close [41] B) Fe 3 O 4 @Mn 3 O 4 nanoparticles, [42] C) MnO@Mn 3 O 4 nanoparticles, [43] D) MnO@SiO 2 nanoparticles, [44] E) hollow MnO 2 nanoparticles, [45] F) Fe 3 O 4 /MnO x -GO nanostructures. [46] Reproducedw ith permission.…”

Section: Manganese Oxidesmentioning

confidence: 99%

“…The idea behind this kind of protocol is to separate the competing processes of nucleation and growth of the NPs, which yields a population of final nanocrystals with an arrow size distribution. Thermal decomposition protocols were also used by Kim et al [42] for the preparation of Mn 3 O 4 shells on top of magnetite (Fe 3 O 4 )N Ps, in this case by using manganese(II) acetylacetonate as Mn source ( Figure 2B). The same precursor (acetylacetonate) was also used by Kim and co-workers [43] to prepare urchin-shaped MnO@Mn 3 O 4 NPs ( Figure 2C).…”

Section: Manganese Oxidesmentioning

confidence: 99%

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

García‐Hevia

Bañobre‐López

Gallo

2018

Chemistry A European J

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Manganese-based nanostructured contrast agents (CAs) entered the field of medical diagnosis through magnetic resonance imaging (MRI) some years ago. Although some of these Mn-based CAs behave as classic T contrast enhancers in the same way as clinical Gd-based molecules do, a new type of Mn nanomaterials have been developed to improve MRI sensitivity and potentially gather new functional information from tissues by using traditional T contrast enhanced MRI. These nanomaterials have been designed to respond to biological environments, mainly to pH and redox potential variations. In many cases, the differences in signal generation in these responsive Mn-based nanostructures come from intrinsic changes in the magnetic properties of Mn cations depending on their oxidation state. In other cases, no changes in the nature of Mn take place, but rather the nanomaterial as a whole responds to the change in the environment through different mechanisms, including changes in integrity and hydration state. This review focusses on the chemistry and MR performance of these responsive Mn-based nanomaterials.

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“…41,46 Gold nanoshells and Fe 3 O 4 NPs have been used to prepare a core-shell structured delivery system that had the dual-mode imaging effect. 33 Kim et al 47 used Mn 2+ and Fe 3 O 4 to prepare a delivery system, showing the T 1 /T 2 dual-mode MRI effect. Nowadays, in cancer research, a number of dual-mode imaging drug delivery systems have been constructed for tumor theranostic applications 48,49 as they have more advantages.…”

Section: Effects Of Mri and X-ray Imaging In Vivomentioning

confidence: 99%

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

Wang¹,

Liu²,

Hao³

et al. 2017

IJN

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Recently, photothermal therapy has become a promising strategy in tumor treatment. However, the therapeutic effect was seriously hampered by the low tissue penetration of laser. Therefore, in this study, radiofrequency (RF) with better tissue penetration was used for tumor hyperthermia. First, one type of gold nanorods (AuNRs) suitable for RF hyperthermia was selected. Then, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with AuNRs and docetaxel (DTX) (PLGA/AuNR/DTX) NPs were constructed. Finally, manganese dioxide (MnO 2 ) ultrathin nanofilms were coated on the surfaces of PLGA/AuNR/DTX NPs by the reduction of KMnO 4 to construct the PLGA/AuNR/DTX@MnO 2 drug delivery system. This drug delivery system can not only be used for the combined therapy of chemotherapy and RF hyperthermia but can also produce Mn 2+ to enable magnetic resonance imaging. Furthermore, the RF hyperthermia and the degradation of MnO 2 can significantly promote the controlled drug release in a tumor region. The in vitro and in vivo results suggested that the PLGA/AuNR/DTX@MnO 2 multifunctional drug delivery system is a promising nanoplatform for effective cancer theranostic applications.

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Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

Cited by 59 publications

References 37 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

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Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

Cited by 59 publications

References 37 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

Gold nanorod&ndash;based poly(lactic-co-glycolic acid) with manganese dioxide core&ndash;shell structured multifunctional nanoplatform for cancer theranostic applications

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Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications