Iron-Overload-Associated Myopathy in Patients on Maintenance Hæmodialysis: A Histocompatibility-Linked Disorder

Bregman, H; Winchester, J F; Knepshield, J H; Gelfand, MichaelC.; Manz, Herbert J.; Schreiner, G. E.

doi:10.1016/s0140-6736(80)92047-4

Cited by 75 publications

(35 citation statements)

References 19 publications

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“…Bregman et al [13] recently described a clini cal syndrome of severe proximal myopathy associated with iron overload in 10 patients on periodic hemodial ysis and found that 9 of the 10 patients revealed the presence of HA. The same authors showed that the patients with HA antigens had elevated SF values when compared to patients in whom these antigens were ab sent.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Bregman et al [13] have shown that hemodialysis pa tients bearing 'hemochromatosis allele(s)' (HA) present a higher risk of iron overload. A recent study carried out by us [14] has shown that repeated blood transfusions can induce an increase of serum ferritin levels, indicat ing an iron overload in hemodialysis patients related to the presence of HA antigens.…”

Section: Introductionmentioning

confidence: 99%

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Risk of Iron Overload and Ηemochromatosis Allele(s)’ in Patients on Maintenance Hemodialysis

Taccone-Gallucci¹,

Nucci²,

Meloni³

et al. 1987

Am J Nephrol

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In the present study, we have evaluated the relationship between serum ferritin (SF) levels, ‘hemochromatosis allele(s)’, blood transfusions and iron parenteral administration in 69 hemodialysis patients. We demonstrated significantly higher SF levels in patients with hemochromatosis allele(s) (HA⁺) than in patients without hemochromatosis alleles (HA^-). In addition, HA⁺ patients who had received blood transfusions up to 15 months prior to the study had SF levels even higher than those without blood transfusions. On the other hand, HA^- patients had normal levels of SF, independent of blood transfusions. After intravenous administration of 1 g iron saccharate, SF levels were significantly higher only in HA+ transfused patients. In conclusion, our study demonstrated that HA⁺ patients are at a higher risk of iron overload and therefore the use of transfusional and/or parenteral iron should be strictly limited.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk of Iron Overload and Ηemochromatosis Allele(s)’ in Patients on Maintenance Hemodialysis

Taccone-Gallucci¹,

Nucci²,

Meloni³

et al. 1987

Am J Nephrol

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“…4], The pathogenesis of uremic myopathy can be multifactorial. Several sys temic diseases, anemia and malnutrition can impair muscle function in chronic renal failure [10][11][12]. A car nitine deficiency has also been suggested as contributing to muscle dysfunction in uremia [3].…”

Section: Discussionmentioning

confidence: 99%

Effect of Parathyroidectomy on Respiratory Muscle Strength in Uremic Myopathy

Gómez-Fernández¹,

Agudo²,

Miguel³

et al. 1987

Am J Nephrol

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“…In the study by Nakagawa et al, serum ferritin levels were found to be independently negatively associated with HGS (24). In a study performed on HD patients with severe proximal myopathy, muscle biopsies showed iron deposition in macrophages and muscle fibers (25). It is hypothesized that accumulated iron in myoglobin causes free radical formation in muscle leading to impaired muscle functions.…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Nementioning

confidence: 97%

Handgrip Strength and Serum Uric Acid Levels are Associated with Dialysis-Malnutrition Scores in Chronic Hemodialysis Patients

Başçı¹,

Özkök²,

Kacar³

et al. 2017

Turk Neph Dial Transpl

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OBJECTIVE: Protein-energy-wasting (PEW) is common and contributes to increased mortality in hemodialysis (HD) patients. Herein we aimed to investigate the relationships between the parameters of malnutrition including dialysis malnutrition score (DMS), bioimpedance analysis (BIA), handgrip strength (HGS) in chronic HD patients. MATERIAL and METHODS:Forty chronic HD patients (mean age:58±18 years; males:22) were enrolled. Mid-arm circumference (MAC) measurements and BIA were performed. HGS was measured by a Jamar hydraulic hand dynamometer. RESULTS:HGS, MAC and uric acid levels were higher in patients with mild malnutrition compared to severe malnutrition group. Postdialysis creatinine was associated with lean body ratio (LBR) (r=0.56, p=0.002), DMS (r=-0.57, p=<0.001), HGS (r=0.73, p<0.001) and MAC (r=0.51, p=0.001). DMS was inversely correlated with HGS (r= -0.63, p<0.001), MAC (r= -0.48, p=0.002), total protein (r=-0.36, p=0.02) and uric acid levels (r=-0.54, p<0.001). In linear regression analysis (R 2 =0.58; p<0.001), HGS and uric acid were found to independently predict DMS. HGS was associated with MAC, LBR, uric acid and post-HD urea. HGS was negatively correlated with age, DMS, fat tissue ratio (FTR) and Kt/V. In linear regression analysis (R 2 =0.71; p<0.001), gender, DMS and MAC were found to independently predict HGS.CONCLUSION: HGS and uric acid were significantly associated with dialysis-malnutrition scores. HGS is an easy and reliable test for the evaluation of malnutrition in HD patients.KEy wORDS: Malnutrition, Hemodialysis, Handgrip strength, Dialysis malnutrition score, Uric acid Öz AMAÇ: Protein-enerji tükenmesi sendromu, hemodiyaliz (HD) hastalarında sıktır ve artmış mortalite ile ilişkilidir. Burada, el-sıkma gücünün (ESG); diyaliz malnütrisyon skoru (DMS) ve biyoimpedans analizi (BİA) gibi diğer malnütrisyon parametreleri ile ilişkisinin araştırılması amaçlanmıştır. GEREÇ ve yÖNTEMLER:Kırk kronik HD hastası (ortalama yaş: 58±18 yıl; erkek :22) çalışmaya katıldı. Orta-kol çevresi (OKÇ) ve BİA ölçümleri yapıldı. ESG, Jamar hidrolik el dinamometresi ile ölçüldü.BULGULAR: ESG, OKÇ ve ürik asit seviyeleri, hafif malnütrisyon grubunda, ciddi malnütrisyon grubuna göre daha yüksek saptandı. Postdiyaliz kreatinin seviyeleri, yağsız vücut oranı (YVO) (r=0,56, p=0,002), DMS(r= -0,57, p=<0,001), ESG(r=0,73, p<0,001) ve OKÇ(r=0,51, p=0,001) ile anlamlı olarak ilişkili bulundu. DMS ise ESG 63, p<0,001),48, p=0,002),36, p=0,02) ve ürik asit seviyeleri (r=-0,54, p<0,001) ile ters-ilişkili bulundu. Lineer regresyon analizinde (R 2 =0,58; p<0,001), ESG ve ürik asitin DMS'nin bağımsız öngörücüleri olduğu bulundu. ESG ile OKÇ, YVO, ürik asit ve post-HD üre değerleri ilişkiliydi. Buna karşın ESG; yaş, DMS, yağ doku oranı ve Kt/V ile ters ilişkili bulundu. Lineer regresyon analizinde (R 2 =0,71; p<0,001), cinsiyet, DMS ve OKÇ'nin ESG'nin bağımsız öngörücüleri oldukları gösterildi. SONUÇ: ESG ve ürik asit seviyeleri, diyaliz-malnütrisyon skorlarıyla anlamlı olarak ilişkilidir. ESG, HD hastalarında malnütr...

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Iron-Overload-Associated Myopathy in Patients on Maintenance Hæmodialysis: A Histocompatibility-Linked Disorder

Cited by 75 publications

References 19 publications

Risk of Iron Overload and Ηemochromatosis Allele(s)’ in Patients on Maintenance Hemodialysis

Risk of Iron Overload and Ηemochromatosis Allele(s)’ in Patients on Maintenance Hemodialysis

Effect of Parathyroidectomy on Respiratory Muscle Strength in Uremic Myopathy

Handgrip Strength and Serum Uric Acid Levels are Associated with Dialysis-Malnutrition Scores in Chronic Hemodialysis Patients

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Iron-Overload-Associated Myopathy in Patients on Maintenance Hæmodialysis: A Histocompatibility-Linked Disorder

Cited by 75 publications

References 19 publications

Risk of Iron Overload and &Eta;emochromatosis Allele(s)&rsquo; in Patients on Maintenance Hemodialysis

Risk of Iron Overload and &Eta;emochromatosis Allele(s)&rsquo; in Patients on Maintenance Hemodialysis

Effect of Parathyroidectomy on Respiratory Muscle Strength in Uremic Myopathy

Handgrip Strength and Serum Uric Acid Levels are Associated with Dialysis-Malnutrition Scores in Chronic Hemodialysis Patients

Contact Info

Product

Resources

About

Risk of Iron Overload and Ηemochromatosis Allele(s)’ in Patients on Maintenance Hemodialysis

Risk of Iron Overload and Ηemochromatosis Allele(s)’ in Patients on Maintenance Hemodialysis