Iron, Nitric Oxide, and Myeloperoxidase in Asthmatic Patients

Ekmekci, Ömer; Donma, Orkide; Sardogan, E; Yıldırım, Nurhayat; Uysal, Ömer; Demirel, Hande; Demir, Türkay

doi:10.1023/b:biry.0000026205.89894.25

Cited by 27 publications

(17 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Iron intake continues to be low for female adolescents, both in the US and Europe, despite increased total energy intake since the 1960’s[41, 42]. Previous research has demonstrated an increased risk between high serum iron and asthma[43–45]; however, these were retrospective investigations of adult or childhood iron levels, rather than in-utero exposures.…”

Section: Discussionmentioning

confidence: 99%

Association of maternal anemia with increased wheeze and asthma in children

Triche

Lundsberg

Wickner

et al. 2011

Annals of Allergy, Asthma & Immunology

View full text Add to dashboard Cite

IntroductionAsthma and respiratory disease account for increasing childhood morbidity, placing a burden on the health care system and on affected individuals and families. In 2007, approximately 6.7 million children under the age of 18 had asthma [1], with rates increasing to nearly 7 million (9.4%) by 2008 [2]. As of 2008, more than 14% of children 0-17 had been diagnosed with asthma [2], with children 0-4 years demonstrating the greatest use of health care services for asthma related illness [1]. Increases in childhood respiratory disease over the past decades have highlighted the need to identify specific factors associated with © 2010 American College of Allergy, Asthma and Immunology. Published by Elsevier Inc. All rights reserved.Corresponding Author and Request for Reprints: Elizabeth W. Triche, Brown University, Department of Community Health/ Epidemiology, Box G-S121-2, 121 S. Main St., Providence, RI 02912, Tel: 401 863-1987, Fax: 401 863-3713, Elizabeth_triche@brown.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of Interest:Michael Bracken and Paige Wickner work as occasional contractors for Pfizer although the research in this paper is not related in any way to compensation received from this company. All other authors do not have any conflict of interest. early childhood wheezing and childhood asthma. The rise in prevalence of asthma is too rapid to be due to genetic mutations, and air pollution has actually declined in many areas where asthma rates have been increasing. NIH Public AccessRecent research has suggested that maternal dietary factors during pregnancy may influence the development of childhood asthma [3,4]. The intrauterine environment provides the substrate for many important processes including lung and early immune system development, and support of optimal fetal growth requires adequate maternal nutritional status. Lung development in-utero is apparent within 3-4 weeks after fertilization and continues throughout gestation and childhood [5]. [6] It is possible, then, that inadequate nutritional status during gestation may negatively impact childhood respiratory health [3,4], particularly during critical periods of embryonic and fetal growth.Maternal anemia, an indicator of overall nutritional status, has been linked to a number of adverse outcomes including infant mortality, preterm delivery, poor gestational weight gain, low birth weight, and poor infant neurocognitive performance [7][8][9]. Anemia is prevalent in the 4 pregnant population in the United States (9.3% in the general pregnant population and up to 27% in low incom...

show abstract

Section: Discussionmentioning

confidence: 99%

Association of maternal anemia with increased wheeze and asthma in children

Triche

Lundsberg

Wickner

et al. 2011

Annals of Allergy, Asthma & Immunology

View full text Add to dashboard Cite

show abstract

“…The prevalence of asthma is higher in patients with disorders such as thalassaemia minor and sickle cell anaemia, which cause elevated systemic iron levels compared to patients without haemoglobinopathies [8]. Furthermore, it has been observed that asthmatic patients show increased plasma levels of iron compared to healthy controls [9]. Moreover, data from animal models also point to a role for iron in allergic manifestations.…”

Section: Introductionmentioning

confidence: 99%

Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma

Maazi

Shirinbak

Bloksma

et al. 2011

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryThe prevalence of allergic diseases has increased dramatically during the last four decades and is paralleled by a striking increase in iron intake by infants in affluent societies. Several studies have suggested a link between increased iron intake and the marked increase in prevalence of allergic diseases. We hypothesized that the increased iron intake by infants offers an explanation for the increased prevalence of allergic disease in industrialized societies during the past four decades. A well-established mouse model of ovalbumin (OVA)-driven allergic asthma was used to test the effects of differences in iron intake and systemic iron levels on the manifestations of allergic asthma. Surprisingly, iron supplementation resulted in a significant decrease in airway eosinophilia, while systemic iron injections lead to a significant suppression of both allergen-induced airway eosinophilia and hyperreactivity compared to placebo. In contrast, mice fed on an iron-deprived diet did not show any difference in developing experimentally induced allergic asthma when compared to those fed on an iron-sufficient control diet. In contrast to our hypothesis, airway manifestations of allergic asthma are suppressed by both increased levels of iron intake and systemic iron administrations in the mouse model.

show abstract

“…A previous study reported normal serum MPO and iron levels as 62 ± 11 ng/ml and 96 ± 9 μg/dl, respectively [75]. However, there was a significant increase in serum MPO and iron levels to 95 ± 20 ng/ml and 159 ± 20 μg/dl, respectively, in asthmatic individuals [75]. Although there was an increase in this reported serum iron, these levels still fell within the normal range (50 to 170 μg/dl) [22,75].…”

Section: Biomarkers For the Early Detection Of Ovarian Cancermentioning

confidence: 81%

“…Myeloperoxidase levels reported for various inflammatory disorders are coincidentally lower than those levels found in all stages of ovarian cancer. A previous study reported normal serum MPO and iron levels as 62 ± 11 ng/ml and 96 ± 9 μg/dl, respectively [75]. However, there was a significant increase in serum MPO and iron levels to 95 ± 20 ng/ml and 159 ± 20 μg/dl, respectively, in asthmatic individuals [75].…”

Section: Biomarkers For the Early Detection Of Ovarian Cancermentioning

confidence: 94%

New Insights into the Pathogenesis of Ovarian Cancer: Oxidative Stress

Saed¹,

Morris²,

Fletcher³

2018

Ovarian Cancer - From Pathogenesis to Treatment

View full text Add to dashboard Cite

Ovarian cancer is the leading cause of death from gynecologic malignancies yet the underlying pathophysiology is not clearly established. Epithelial ovarian cancer (EOC) has long been considered a heterogeneous disease with respect to histopathology, molecular biology, and clinical outcome. Treatment of ovarian cancer includes a combination of cytoreductive surgery and combination chemotherapy, with platinums and taxanes. Despite initial success, over 75% of patients with advanced disease will relapse around 18 months and the overall 5-year survival is approximately 50%. Cancer cells are known to be under intrinsic oxidative stress, which alters their metabolic activity and reduces apoptosis. Epithelial ovarian cancer has been shown to manifest a persistent pro-oxidant state as evident by the upregulation of several key oxidant enzymes in EOC tissues and cells. In the light of our scientific research and the most recent experimental and clinical observations, this chapter provides the reader with up to date most relevant findings on the role of oxidative stress in the pathogenesis and prognosis of ovarian cancer, as well as a novel mechanism of apoptosis/survival in EOC cells.

show abstract

Iron, Nitric Oxide, and Myeloperoxidase in Asthmatic Patients

Cited by 27 publications

References 21 publications

Association of maternal anemia with increased wheeze and asthma in children

Association of maternal anemia with increased wheeze and asthma in children

Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma

New Insights into the Pathogenesis of Ovarian Cancer: Oxidative Stress

Contact Info

Product

Resources

About