IRON MAN is a ubiquitous family of peptides that control iron transport in plants

Grillet, Louis; Lan, Ping; Li, Wen Feng; Mokkapati, Girish; Schmidt, Wolfgang

doi:10.1038/s41477-018-0266-y

Cited by 195 publications

(273 citation statements)

References 68 publications

(72 reference statements)

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“…IMAs likely represent the most upstream component of the iron signaling cascade common to both iron acquisition strategies. IMAs in rice, and generally in monocots, appear to be evolutionarily closer to AtIMA3, mainly due to a longer aspartic acid repeat in the conserved motif compared to other Arabidopsis IMA peptides (Grillet et al ., ; Fig. S5).…”

Section: A Conserved Cluster Of Proteins Regulates Iron Uptake and DImentioning

confidence: 97%

“…. AtIRP1 and AtIRP2 have been later renamed to AtIMA1 and AtIMA2 , and share similarities with OsIMA1 and OsIMA2 in their C‐terminus (Grillet et al ., ). OsIRP6 (Os03g52680) is homologous to AtIRP5 and AtIRP6 .…”

Section: Imas and Irps May Play Critical But Yet Unexplored Roles In mentioning

confidence: 97%

“…A recently discovered novel family of peptides named IRONMAN (IMA) or FE‐UPTAKE‐INDUCING PEPTIDE (FEP) positively regulates subgroup 1b bHLH genes in Arabidopsis (Grillet et al ., ; Hirayama et al ., ). Overexpression of IMAs causes iron and manganese accumulation, a function which is dependent on a C‐terminal amino acid motif that is conserved among IMA peptides across species (Grillet et al ., ). Genes encoding IMA peptides in rice are highly induced by iron deficiency and co‐expressed with other iron homeostasis genes, suggesting that the function of IMA peptides is conserved.…”

Section: A Conserved Cluster Of Proteins Regulates Iron Uptake and DImentioning

confidence: 98%

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Iron acquisition strategies in land plants: not so different after all

Grillet

Schmidt

2019

New Phytologist

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Summary Due to its ability to accept and donate electrons, iron (Fe) is an indispensable component of electron transport chains and a cofactor in many vital enzymes. Except for waterlogged conditions, under which the lack of oxygen prevents oxidation and precipitation of iron as Fe3+ hydroxides, the availability of iron in soils is generally far below the plant's demand for optimal growth. Plants have evolved two phylogenetically separated and elaborately regulated strategies to mobilize iron from the soil, featuring mechanisms which are thought to be mutually exclusive. However, recent studies uncovered several shared components of the two strategies, questioning the validity of the concept of mutual exclusivity. Here, we use publicly available data obtained from the model species rice (Oryza sativa) to unveil similarities and incongruities between co‐expression networks derived from transcriptomic profiling of iron‐deficient rice and Arabidopsis plants. This approach revealed striking similarities in the topographies of the resulting co‐expression networks with relatively minor deviations in the molecular attributes of the comprised genes, which nonetheless lead to different physiological functions. The analysis also discovered several novel players that are possibly involved in the regulation plant adaptation to iron deficiency.

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Section: A Conserved Cluster Of Proteins Regulates Iron Uptake and DImentioning

confidence: 97%

Section: Imas and Irps May Play Critical But Yet Unexplored Roles In mentioning

confidence: 97%

Section: A Conserved Cluster Of Proteins Regulates Iron Uptake and DImentioning

confidence: 98%

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Iron acquisition strategies in land plants: not so different after all

Grillet

Schmidt

2019

New Phytologist

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“…Elevated accumulation of nicotianamine enhanced sensitivity to Fe deficiency but could tolerate Ni toxicity (Klatte et al , ). Transgenic plants overexpressing IRON MAN 1 ( IMA1 ) showed necrotic spots on the leaves indicating sensitivity to both Fe‐sufficient and Fe‐deficient conditions (Grillet et al , ). Hence, targeting single genes for genetic engineering appears to be an unfavourable approach for biofortification.…”

Section: Discussionmentioning

confidence: 99%

“…Samples were washed 2–3 times with distilled water. For embryo staining, Perl’s staining was intensified with diaminobenzidine DAB as described (Grillet et al , ).…”

Section: Methodsmentioning

confidence: 99%

The dual benefit of a dominant mutation in Arabidopsis IRON DEFICIENCY TOLERANT1 for iron biofortification and heavy metal phytoremediation

Sharma

Yeh

2019

Plant Biotechnology Journal

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Summary One of the goals of biofortification is to generate iron‐enriched crops to combat growth and developmental defects especially iron (Fe) deficiency anaemia. Fe‐fortification of food is challenging because soluble Fe is unstable and insoluble Fe is nonbioavailable. Genetic engineering is an alternative approach for Fe‐biofortification, but so far strategies to increase Fe content have only encompassed a few genes with limited success. In this study, we demonstrate that the ethyl methanesulfonate (EMS) mutant, iron deficiency tolerant1 (idt1), can accumulate 4–7 times higher amounts of Fe than the wild type in roots, shoots and seeds, and exhibits the metal tolerance and iron accumulation (Metina) phenotype in Arabidopsis. Fe‐regulated protein stability and nuclear localisation of the upstream transcriptional regulator bHLH34 were uncovered. The C to T transition mutation resulting in substitution of alanine to valine at amino acid position 320 of bHLH34 (designated as IDT1A320V) in a conserved motif among mono‐ and dicots was found to be responsible for a dominant phenotype that possesses constitutive activation of the Fe regulatory pathway. Overexpression of IDT1A320V in Arabidopsis and tobacco led to the Metina phenotype; a phenotype that has escalated specificity towards optimising Fe homeostasis and may be useful in Fe‐biofortification. Knowledge of the high tolerance and accumulation of heavy metals of this mutant can aid the development of tools for phytoremediation of contaminants.

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Iron Excess Toxicity and Tolerance in Crop Plants

Aung,

Masuda

2023

Heavy Metal Toxicity and Tolerance in Plants

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IRON MAN is a ubiquitous family of peptides that control iron transport in plants

Cited by 195 publications

References 68 publications

Iron acquisition strategies in land plants: not so different after all

Iron acquisition strategies in land plants: not so different after all

The dual benefit of a dominant mutation in Arabidopsis IRON DEFICIENCY TOLERANT1 for iron biofortification and heavy metal phytoremediation

Iron Excess Toxicity and Tolerance in Crop Plants

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