Iron induced genotoxicity: attenuation by vitamin C and its optimization

Parveen, Nazia; Ahmad, Shoeb; Shadab, G. G. H. A.

doi:10.2478/intox-2014-002

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…These antioxidants are able to scavenge free radicals and help to reduce the extent of oxidative stress-induced DNA damages. Excess of iron is believed to cause oxidative stress and is understood as an increase in the steady state concentration of reactive oxygen and nitrogen species (24)(25)(26)(27)(28). The toxicity of superoxide anion (O production (30,31); the low redox potentials of flavonoids thermodynamically allow them to reduce highly oxidising (32); and a number of flavonoids chelate trace metals (33).…”

Section: Discussionmentioning

confidence: 99%

The dual clastogenic and anti-clastogenic properties of quercetin is dose dependent

Parveen

Shadab

2017

Front Biosci

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The antioxidant properties of quercetin 140 © 1996-2017 antioxidant, anticarcinogenic, anti-inflammatory, and cardioprotective activities (10, 11). While these properties may account for the antimutagenic activity of flavonoids in experimental systems, results from different studies (12-14) demonstrated that QCT can also act as pro-oxidant at much higher doses. However, the molecular mechanisms of the mutagenicity of flavonoids are not well known. This indicates that QCT may have conflicting roles, i.e., as an antioxidant and as a pro-oxidant, depending on the concentration used. A recent study has demonstrated that the flavonoids, rutin and QCT, play a protective role in the context of the deleterious effects of free radicals in cirrhotic rats (15). Therefore, more studies are required in vivo to ascertain the beneficial/ toxic effects of QCT. The present study focuses on the protective role of QCT in pre-, simultaneous and posttreatments against genotoxicity induced by iron sulfate in vivo, as determined by bone marrow chromosomal aberration, micronucleus and comet assays.

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Section: Discussionmentioning

confidence: 99%

The dual clastogenic and anti-clastogenic properties of quercetin is dose dependent

Parveen

Shadab

2017

Front Biosci

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Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model

Ajibade

Oyagbemi

Omobowale

et al. 2016

Biol Trace Elem Res

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The objective of the present work was to evaluate the toxic effects of cobalt chloride, a potent oxidative stress-inducing chemical, at 650 ppm in rats and the protective effect of quercetin and/or vitamin C against the cobalt chloride-induced toxicity. Thirty rats were randomly selected, and assigned to one of five groups: control, cobalt chloride, cobalt chloride + quercetin, cobalt chloride + vitamin C and cobalt chloride + quercetin + vitamin C. The exposure of rats to cobalt chloride led to a significant increase (p < 0.05) in malondialdehyde (MDA) and hydrogen peroxide (HO) generated, but decreased nitric oxide (NO) bioavailability. Also, significant (p < 0.05) reductions were observed in the activity of glutathione peroxidase (GPx) and reduced glutathione (GSH) content in the cardiac and renal tissues. Treatment with quercetin and vitamin C reversed the effect of cobalt chloride on MDA, HO and NO, more potently than with either of the two antioxidants, and increased the antioxidant defence system. Further, treatment of rats with quercetin and vitamin C in combination resulted in significant (p < 0.05) decreases in the systolic, diastolic, and mean arterial blood pressure of rats, relative to those exposed to cobalt chloride alone. Immunohistochemical studies revealed a greater expression of nuclear factor kappa beta (NF-kB) in the cobalt chloride group compared with the control- and antioxidants-treated rats. The results of this study suggest a protective role for quercetin and vitamin C in the amelioration of the toxic mechanisms leading to cobalt chloride-induced hypertension and its associated cardiac and renal complications in rats.

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Iron induced genotoxicity: attenuation by vitamin C and its optimization

Cited by 2 publications

References 26 publications

The dual clastogenic and anti-clastogenic properties of quercetin is dose dependent

The dual clastogenic and anti-clastogenic properties of quercetin is dose dependent

Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model

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