The dual clastogenic and anti-clastogenic properties of quercetin is dose dependent

Abstract

The antioxidant properties of quercetin 140 © 1996-2017 antioxidant, anticarcinogenic, anti-inflammatory, and cardioprotective activities (10, 11). While these properties may account for the antimutagenic activity of flavonoids in experimental systems, results from different studies (12-14) demonstrated that QCT can also act as pro-oxidant at much higher doses. However, the molecular mechanisms of the mutagenicity of flavonoids are not well known. This indicates that QCT may have conflicting roles, i.e., as an antioxidant and as a pro-oxidant, depending on the concentration used. A recent study has demonstrated that the flavonoids, rutin and QCT, play a protective role in the context of the deleterious effects of free radicals in cirrhotic rats (15). Therefore, more studies are required in vivo to ascertain the beneficial/ toxic effects of QCT. The present study focuses on the protective role of QCT in pre-, simultaneous and posttreatments against genotoxicity induced by iron sulfate in vivo, as determined by bone marrow chromosomal aberration, micronucleus and comet assays.

Evaluation of DNA interaction, genotoxicity and oxidative stress induced by iron oxide nanoparticles both in vitro and in vivo: attenuation by thymoquinone

“…In recent times, the toxic effects of nanoparticles have raised serious concern over its application in various fields of science. Iron is an important constituent of hemoglobin, several enzymes and electron transport system of the cells 35 . However, above the threshold level, iron also contributes to the production of ROS that causes oxidative stress and induces damage to the tissues and organs of the body 28 .…”

Polyphenols as anticancer agents: Toxicological concern to healthy cells

“…One earlier study reported DNA damage in mouse bone marrow cells treated with a high concentration of quercetin (1,250 mg/kg) (da Silva et al, 2002). Parveen and Shadab (2017) reported both the clastogenic and anti-clastogenic potential of quercetin which depends on exposure concentrations. A recent study reported increase in AST, ALT, and direct bilirubin levels due to 50 mg/kg quercetin exposure in an animal model (Ortiz-Andrade et al, 2020;Parveen & Shadab, 2017).…”

“…Parveen and Shadab (2017) reported both the clastogenic and anti-clastogenic potential of quercetin which depends on exposure concentrations. A recent study reported increase in AST, ALT, and direct bilirubin levels due to 50 mg/kg quercetin exposure in an animal model (Ortiz-Andrade et al, 2020;Parveen & Shadab, 2017). An earlier study by National Toxicology Program demonstrated the sex-related differences in rats in the presence or absence of renal tubule carcinoma.…”