Iron(III)- and copper(II) complexes of an asymmetric, pentadentate salen-like ligand bearing a pendant carboxylate group

Vanadium (IV and V) Complexes of Reduced Schiff Bases Derived from the Reaction of Aromatic o‐Hydroxyaldehydes and Diamines Containing Carboxyl Groups

“…The protonation constants and respective pK a values derived from the potentiometric titrations are listed in Table 1. These values agree well with those obtained by Jancsó et al, [18] for a different medium. The pK a of the carboxyl group is too low to be determined by potentiometric measurements, this is because of the strong electron-withdrawing effect of the neighbouring amino groups and/or H-bond formation involving these groups.…”

“…However, as salLys (3) is not soluble in water or in ethanol/water at least up to 10 % ethanol, this compound was characterised in the solid state but was not further studied. Studies of moderately water-soluble Schiff bases and their hydrolytically more stable salan derivatives were previously reported, [15,17] [18] and in this work we also find that it is an effective ligand for V IV O 2+ and V V O 2 + . Moreover, the pendant carboxylate group may help with the coupling of the salan moiety to other molecules that may target the compound to specific biological sites, thereby anticipating the possibility of minimising its toxicity and increasing its efficacy.…”

“…practically no change in the UV spectra occurs during this step, this can be assigned to the deprotonation of an amino group. [18] In Figure S1 it is clear that only the chemical shifts of the protons attached to C atoms close to the N amine atoms show significant changes at pD Ϸ 6, in particular the proton attached to C(9) shows important changes. This indicates that pK a2 is mainly associated with the deprotonation of atom N(2).…”

Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a single-drug anticancer platform

“…In other words, the Fe(salen) metal complexes, which have been used in the last few decades as asymmetric catalysts [17][18][19][20] and molecular magnets, 21,22 can be employed as magnetically guided anticancer agents. 13,14 Other molecular magnets have been reported but cannot be practically applied due to the very low critical temperature at which they exhibit positive values of magnetization in response to a room temperature magnetic field.…”

New salen-type manganese(III) Schiff base complexes derived from meso-1,2-diphenyl-1,2-ethylenediamine: In vitro anticancer activity, mechanism of action, and molecular docking studies

“…Salen-metal complexes have very high binding constants in the range of log K> 20 [12,13] which has made them suitable for several purposes. Coordination chemistry of manganese has been investigated for applications such as catalysis, antibacterial and anti-fungal drugs, catalytic activity for specific DNA and RNA cleavage reactions, and many other applications [14][15][16][17][18][19].…”