Iron deficiency in Russia heart failure patients. Observational cross-sectional multicenter study

Abstract

Aim To evaluate the prevalence of iron deficiency (ID) in Russian patients with heart failure (HF).Material and methods Iron metabolism variables were studied in 498 (198 women, 300 men) patients with HF. Data were evaluated at admission for HF (97 %) or during an outpatient visit (3 %). ID was determined according to the European Society of Cardiology Guidelines.Results 83.1 % of patients had ID; only 43.5 % of patients with ID had anemia. Patients with ID were older: 70.0 [63.0;79.0] vs. 66.0 years [57.0;75.2] (p=0.009). The number of patients with ID increased in parallel with the increase in HF functional class (FC). Among patients with ID, fewer people were past or current alcohol users (p=0.002), and a greater number of patients had atrial fibrillation (60.1 vs. 45.2 %, p=0.016). A multiple logistic regression showed that more severe HF (HF FC) was associated with a higher incidence of ID detection, whereas past alcohol use was associated with less pronounced ID. An increase in N-terminal pro-brain natriuretic peptide (NT-proBNP) by 100 pg/ml was associated with an increased likelihood of ID (odds ratio, 1.006, 95 % confidence interval: 1.002–1.011, p=0.0152).Conclusion The incidence rate of HF patients is high in the Russian Federation (83.1 %). Only 43.5 % of these patients had anemia. The prevalence of ID in the study population increased with increases in HF FC and NT-proBNP.

Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines

“…В дополнительном анализе исследования ЭПОХА ХСН была уточнена распространенность ФП в российский популяции. По данным этого исследования распространенность ФП составила 2,1% в популяции и 12,3% среди пациентов с ХСН [520].…”

“…Анализ пациентов с диагнозом ФП, имевших и не имевших ХСН, также показал высокую частоту наличия сопутствующих заболеваний у пациентов с ХСН [448]. Российское многоцентровое наблюдательное исследование изучившие частоту дефицита железа у пациентов с ХСН (97% из них это госпитализированные пациенты) показало, что у 83,1% пациентов с ХСН имел место дефицит железа [520]. Регистр ОРАКУЛ, включавший пациентов, госпитализированных с синдромом острой декомпенсации СН показал, что 77% включенных пациентов имели ИБС, 55% -АГ, 16% -ХОБЛ, 23% -ХБП, 24% -СД [521].…”

Iron and atrial fibrillation: A review

“…In a crosssectional multicenter study in Russia, the relationship between iron deficiency, AF, and HF was explored. 65…”

“…Iron deficiency appears to be more common in patients with HF than iron overload. In a cross‐sectional multicenter study in Russia, the relationship between iron deficiency, AF, and HF was explored 65 . Among the 498 HF patients, 83.1% of the HF patients were accompanied by iron deficiency.…”