Iron Deficiency in Obesity and after Bariatric Surgery

Bjørklund, Geir; Peana, Massimiliano; Pivina, Lyudmila; Doşa, Alexandru; Aaseth, Jan; Semenova, Yuliya; Chirumbolo, Salvatore; Medici, Serenella; Dadar, Maryam; Costea, Daniel-Ovidiu

doi:10.3390/biom11050613

Cited by 35 publications

(25 citation statements)

References 137 publications

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“…The effect of HIV-infection risk factors on adverse perinatal outcomes has not yet been disclosed. Risk factors such as poverty, lack of social support, anemia, diabetes, hypertension, chemo- or radiotherapy including different oncologic treatments [ 19 ], bariatric surgery involvement [ 20 ], or other pathogenic agents similar to hyper-virulent Klebsiella pneumoniae [ 21 ] could have important involvement on growth restriction, preterm birth, or even mortality of newborns [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

et al. 2023

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Background and Objectives: The present study assessed the fetal growth restriction and clinical parameters of both human immunodeficiency virus (HIV)-negative and HIV-positive newborns from HIV-infected mothers in two HIV-acquired immunodeficiency syndrome regional centers (RCs) in Constanta and Craiova, Romania, in order to evaluate the adverse birth-related outcomes. Materials and Methods: These represent a retrospective study conducted between 2008 and 2019, in which 408 pregnant HIV-positive women, 244 from Constanta RC and 164 from Craiova RC, were eligible to participate in the study. Consecutive singleton pregnancies delivered beyond 24 weeks of pregnancy were included. Growth restriction in newborns was defined as the birth weight (BW) being less than the third percentile, or three out of the following: BW < 10th percentile; head circumference (HC) < 10th percentile; birth length (BL) < 10th percentile; prenatal diagnosis of fetal growth restriction; and maternal pregnancy information. Of the 244 newborns delivered in Constanta, RC, 17 were HIV-positive, while in Craiova, RC, of the 164 newborns, 9 were HIV-positive. All HIV-positive women were on combined antiretroviral therapy (cART) during pregnancy, similar to all HIV-positive newborns who received ARTs for the first six weeks. We search for the influence of anthropometrical parameters (i.e., HC, BL, and BW), as well as clinical parameters (i.e., newborn sex and Apgar score) for both HIV-negative and HIV-positive newborns, along with the survival rate of HIV-positive newborns. Results: There were no differences in the sex of the newborns within either group, with more than 50% being boys. Similarly, the Apgar score did not show any statistically significant values between the two groups (i.e., p = 0.544 for HIV-positive newborns vs. p = 0.108 for HIV-negative newborns). Interestingly, our results showed that in Craiova, RC, there was a chance of 2.16 to find an HIV-negative newborn with an HC < 10th percentile and a 2.54 chance to find an HIV-negative newborn with a BL < 10th percentile compared to Constanta, RC, without any significant differences. On the contrary, Constanta, RC, represented a higher risk of death (i.e., 3.049 times, p = 0.0470) for HIV-positive newborns compared to Craiova, RC. Conclusions: Our results support the idea that follow-up of fetal growth restriction should be part of postnatal care in this high-risk population to improve adverse birth-related outcomes.

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Section: Discussionmentioning

confidence: 99%

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

et al. 2023

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“…A meta-analysis indicated that elevated serum ferritin was a risk factors for type 2 diabetes, and soluble transferrin receptor-to-ferritin ratio was inversely related to the risk of type 2 diabetes [ ( Liu et al, 2020b )]. Moreover, iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation which reduced iron absorption [ ( Bjørklund et al, 2021 )]. Jordi et al uncovered microbiome- and iron-linked metabolomic and transcriptomic signatures involving imbalances in gluconeogenic metabolites, ketone bodies and cellular transport, which altogether modulate liver fat accumulation [( Mayneris-Perxachs et al, 2021 )].…”

Section: Discussionmentioning

confidence: 99%

Iron metabolism-related genes reveal predictive value of acute coronary syndrome

et al. 2022

Front. Pharmacol.

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Iron deficiency has detrimental effects in patients with acute coronary syndrome (ACS), which is a common nutritional disorder and inflammation-related disease affects up to one-third people worldwide. However, the specific role of iron metabolism in ACS progression is opaque. In this study, we construct an iron metabolism-related genes (IMRGs) based molecular signature of ACS and to identify novel iron metabolism gene markers for early stage of ACS. The IMRGs were mainly collected from Molecular Signatures Database (mSigDB) and two relevant studies. Two blood transcriptome datasets GSE61144 and GSE60993 were used for constructing the prediction model of ACS. After differential analysis, 22 IMRGs were differentially expressed and defined as DEIGs in the training set. Then, the 22 DEIGs were trained by the Elastic Net to build the prediction model. Five genes, PADI4, HLA-DQA1, LCN2, CD7, and VNN1, were determined using multiple Elastic Net calculations and retained to obtain the optimal performance. Finally, the generated model iron metabolism-related gene signature (imSig) was assessed by the validation set GSE60993 using a series of evaluation measurements. Compared with other machine learning methods, the performance of imSig using Elastic Net was superior in the validation set. Elastic Net consistently scores the higher than Lasso and Logistic regression in the validation set in terms of ROC, PRC, Sensitivity, and Specificity. The prediction model based on iron metabolism-related genes may assist in ACS early diagnosis.

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“…On the one hand, intake of iron rich food is dramatically decreased in the first months after BS because of a general low food intake and poor tolerance of iron rich foods. On the other hand, RYGB and SG can induce malabsorption due to the decrease in the absorbing surface and the decrease of hydrochloric acid secretion due to the resection of the greater curvature of the stomach [41]. Furthermore, iron absorption may be compromised by other micronutrient supplements like calcium, thereby requiring a separate intake [33].…”

Section: Micronutrients Deficienciesmentioning

confidence: 99%

Precision nutrition in the context of bariatric surgery

Aguas-Ayesa

Yárnoz-Esquíroz

Olazarán

et al. 2023

Rev Endocr Metab Disord

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Bariatric surgery (BS) is the most effective long-term treatment for severe obesity. This review summarizes the main nutritional deficiencies before and after BS, as well as current dietary and supplementation recommendations to avoid them. Likewise, we have reviewed all those aspects that in recent years have been shown to be related to postoperative weight loss (WL) and its subsequent maintenance, such as hormonal changes, dietary patterns, changes in food preference, adherence to recommendations and follow-up, genetic factors and microbiota, among others. Despite all the knowledge, nutritional deficiencies and weight regain after BS are frequent. It is essential to continue studying in this field in order to establish more precise recommendations according to the individual characteristics of patients. It is also a major objective to understand more deeply the role of the factors involved in WL and its maintenance. This will allow the development of precision treatments and nutrition for patients with obesity, optimizing their benefit after BS.

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Iron Deficiency in Obesity and after Bariatric Surgery

Cited by 35 publications

References 137 publications

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

Iron metabolism-related genes reveal predictive value of acute coronary syndrome

Precision nutrition in the context of bariatric surgery

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