Iron deficiency anemia in pregnancy

Breymann, Christian

doi:10.1586/17474108.2013.842683

Cited by 19 publications

(32 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Iron deficiency is one of the most prevalent types of malnutrition, affecting probable two billion people in the world, and pregnant women and young children are affected most severely, because pregnancy and infant growth demand iron (World Health Organization, 2016). Iron is required for basic cellular functions in all of the tissues, especially in the brain and muscle, and is critically important for the oxygen-carrier function of hemoglobin in red blood cells (Breymann, 2015). In the brain, iron is transported by transferrin or divalent metal transporter-1 from the peripheral blood and is essential for the activity of several enzymes involved in myelination process and monoamine neurotransmitter synthesis (Dusek et al, 2015).…”

Section: Asd and Neuroinflammationmentioning

confidence: 99%

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

Nakagawa¹,

Chiba²

2016

Journal of Pharmacology and Experimental Therapeutics

View full text Add to dashboard Cite

Development of social cognition, a unique and high-order function, depends on brain maturation from childhood to adulthood in humans. Autism spectrum disorder (ASD) and schizophrenia have similar social cognitive deficits, although age of onset in each disorder is different. Pathogenesis of these disorders is complex and contains several features, including genetic risk factors, environmental risk factors, and sites of abnormalities in the brain. Although several hypotheses have been postulated, they seem to be insufficient to explain how brain alterations associated with symptoms in these disorders develop at distinct developmental stages. Development of ASD appears to be related to cerebellar dysfunction and subsequent thalamic hyperactivation in early childhood. By contrast, schizophrenia seems to be triggered by thalamic hyperactivation in late adolescence, whereas hippocampal aberration has been possibly initiated in childhood. One of the possible culprits is metal homeostasis disturbances that can induce dysfunction of blood-cerebrospinal fluid barrier. Thalamic hyperactivation is thought to be induced by microglia-mediated neuroinflammation and abnormalities of intracerebral environment. Consequently, it is likely that the thalamic hyperactivation triggers dysregulation of the dorsolateral prefrontal cortex for lower brain regions related to social cognition. In this review, we summarize the brain aberration in ASD and schizophrenia and provide a possible mechanism underlying social cognitive deficits in these disorders based on their distinct ages of onset.

show abstract

Section: Asd and Neuroinflammationmentioning

confidence: 99%

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

Nakagawa¹,

Chiba²

2016

Journal of Pharmacology and Experimental Therapeutics

View full text Add to dashboard Cite

show abstract

“…12,[37][38][39][40] The association between maternal Hb and birth weight follows a U-shaped curve. 41 Hb >13.5 gm/dl or >3 standard deviations higher than the mean of the reference population (i.e., a Hb concentration of >15.0 gm/dl or a Hct of >45.0%), is unusual and suggests inadequate plasma volume expansion (which can be associated with pregnancy problems including pre-eclampsia, poor fetal growth and preterm deliveries). 42,43 In the present study we had only 12 cases (3%) with Hb >13.5 gm/dl and none >14.6gm/dl.…”

Section: Anaemiamentioning

confidence: 99%

Maternal anaemia and its effects on neonatal anthropometric parameters in patients attending a tertiary care institute of Solan, Himachal Pradesh, India

Behal

Vinayak

Sharma

2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Anaemia during pregnancy is a significant concern in India. The consequences of iron deficiency anaemia during pregnancy are often serious and long lasting for both the mother and the foetus. Haematocrit measurement is an acceptable and recommended method for anaemia determination especially in situations where limited resources are available, and the technical support is poor. There is a rough conversion factor of 3 which converts the HCT value to approximate haemoglobin level. Present study desires to know the prevalence of anaemia (with classification into mild, moderate and severe) in 3rd trimester pregnancy, to know effect of anaemia in pregnancy on new-born anthropometric parameters and to assess the validity of the threefold conversion between haemoglobin and haematocrit for the determination of anaemia in pregnancy.Methods: The estimation of haematocrit was done by micro-haematocrit method and estimation of haemoglobin was done by automated blood cell analyzer based on cyanmethemoglobin method. Welch's ANOVA, Post Hoc games Howell test and Bland Altman limits of agreement method were used for statistical analysis.Results: Present study showed that 53.75% women in their 3rd trimester were anaemic (mild, moderate and severe anaemic mothers were 22.25%, 28.25% and 3.25% respectively). The standard 3-fold conversion between the haemoglobin and haematocrit was not found to be valid for the assessment of anaemia in the 3rd trimester pregnancy. Finally, while comparing anthropometric measurements between mild/ no anaemia group with severe anaemia group we found that all measurements were less in severe anaemia group and this difference was statistically significant.Conclusions: This study shows that 53.75% women in their 3rd trimester were anaemic, which closely mimic the WHO data but is about 11% more than the prevalence in Himachal Pradesh. Secondly, the standard 3-fold conversion between the haemoglobin and haematocrit was not found to be valid for the assessment of anaemia in the 3rd trimester pregnancy. Finally, birth weight, height, head circumference, chest circumference and mid-arm circumference were significantly affected by third trimester haemoglobin that too the most in severe anaemia cases.

show abstract

“…There were more than 0.8 billion people suffer from anemia or iron deficiency, and pregnant women are the most vulnerable [14,15]. Ferritin is a universal intracellular protein that stores iron in most tissues.…”

mentioning

confidence: 99%

Evaluation of serum ferritin and thyroid function in the second trimester of pregnancy

Shen

Zhang

et al. 2018

Endocr J

View full text Add to dashboard Cite

Abstract. Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function in pregnant women during the second trimester. Pregnant women with sufficient iodine intake and normal antithyroid antibodies during the second trimester were recruited from the obstetric outpatient department of the Fifth People's Hospital of Fudan University. Serum ferritin (SF) levels, thyroid function, anti-thyroid antibodies and vitamin B12 were determined by electrochemiluminescence immunoassay kit. Maternal serum iron (Fe), unsaturated iron binding capacity (UIBC), hemoglobin (Hb), creatinine (Cr), fasting blood glucose (FBG), and alanine aminotransferase (ALT) were also evaluated. Stepwise regressions performed to evaluate the associations between SF and other maternal parameters. In the second trimester, 11.4% pregnant women had a SF concentration less than 12 μg/L, and 7.6% pregnant women were anemic. SF levels were negatively correlated with serum TSH levels (r = -0.219, p < 0.05), and positively correlated with FT4 levels (r = 0.203, p < 0.05). Linear regression analysis showed only SF, age, week of gestation were significant predictors of regression with TSH as the dependent variable (β: -0.007, -0.059, and 0.118 respectively; all p < 0.05). However consistent relation between the SF levels and FT4 was not observed in stepwise linear regression. Maternal iron status is a determinant of TSH concentrations during pregnancy in pregnant women during the second trimester.Key words: Serum ferritin, Thyroid function, Thyroid stimulating hormone, Pregnancy, The second trimester THYROID DISEASE is a common endocrine disorder prevalent in pregnant women. The prevalence of subclinical hypothyroidism and hypothyroxinemia during the second trimester of pregnancy is 5.96% and 2.29%, respectively in China [1]. Maternal thyroid dysfunction has been reportedly associated with gestational hypertension, gestational diabetes, spontaneous abortion, fetal loss, dysplasia, and inadequate neuropsychological development in children [2][3][4][5]. Chronic autoimmune thyroiditis is the main cause of hypothyroidism during pregnancy [6,7]. Iodine deficiency during pregnancy is also

show abstract

Iron deficiency anemia in pregnancy

Cited by 19 publications

References 49 publications

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

Maternal anaemia and its effects on neonatal anthropometric parameters in patients attending a tertiary care institute of Solan, Himachal Pradesh, India

Evaluation of serum ferritin and thyroid function in the second trimester of pregnancy

Contact Info

Product

Resources

About