Iron-deficiency and pruritus: a possible explanation of their relationship

Tammaro, Antonella; Chello, Camilla; Fraia, Marco Di; Giordano, Domenico; Magri, Francesca; Zollo, Verdiana; Parisella, Francesca Romana; Marco, Gabriella De

doi:10.18203/issn.2455-4529.intjresdermatol20184470

Cited by 8 publications

(7 citation statements)

References 4 publications

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“…Therefore, we speculate that higher activity status and subsequent exposure to UV might predispose to rosacea and concurrently decrease the probability of CI occurrence. Higher haemoglobin concentration might also be associated with lower risk of pruritus; conversely, the role of anaemia in eliciting pruritus is widely acknowledged (50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

Itch in Elderly People: A Cross-sectional Study

Reszke

Białynicki‐Birula²,

Lindner³

et al. 2019

Acta Derm Venerol

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SIGNIFICANCE Chronic itch is a frequent problem of complex aetiopatho genesis, especially among elderly patients. This study ex tensively evaluated the prevalence, clinical characteristics and possible associations of chronic itch with systemic co morbidities and pharmacotherapy in a cohort of elderly pa tients hospitalized in a geriatric ward, which, to the best of our knowledge, have rarely been reported in the literature. The results of this study support the role of an interdisci plinary diagnostic and therapeutic approach to elderly pa tients with chronic itch. Ageing is associated with numerous medical afflictions, including dermatological symptoms and diseases. Chronic itch (CI) in elderly people is a frequent symptom of diverse aetiology. This study assessed the prevalence and detailed clinical features of CI among 153 elderly patients hospitalized in the geriatric ward, including associations with comorbidities and pharmacotherapy. CI affected 35.3% of subjects, most commonly due to cutaneous conditions, mixed aetiology and neurological disorders (53.7%, 25.9% and 11.1% of pruritic subjects, respectively). The mean itch intensity assessed with the 4-Item Itch Questionnaire (4IIQ) was 6.6 ± 2.8 points. Viral hepatitis (p = 0.02), higher serum creatinine concentration (p = 0.02) and coexistent purpuric lesions (p = 0.002) were associated with higher 4IIQ scores. In logistic regression analysis CI correlated positively with female sex, atopic dermatitis, immobility, rheumatoid arthritis and ischaemic neurological diseases, while low-molecularweight heparins, antipruritic drugs, allergy, rosacea and higher haemoglobin concentration had the contrary effect. CI is a frequent and interdisciplinary problem among elderly subjects, which requires a holistic clinical approach.

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Section: Discussionmentioning

confidence: 99%

Itch in Elderly People: A Cross-sectional Study

Reszke

Białynicki‐Birula²,

Lindner³

et al. 2019

Acta Derm Venerol

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“…18 Pruritus with systemic causes constituted 29.8% of our patients. 19 Reported that 14-50% of pruritic adult and elderly patients without a clear dermatologic cause have an underlying internal cause for their symptom. 19 Renal diseases were the most common systemic cause of pruritus in elderly in the present study affecting 46.2% of the cases, as there was statistically significant difference between both groups regarding creatinine level (p value =0.012), which was not in agreement with 9 who found that kidney diseases represent only 9.7% of systemic causes of pruritus in elderly, but in line with our study 20 reported that renal pruritus was the most common systemic cause of pruritus and it affects 50-90% of patients undergoing peritoneal dialysis or hemodialysis.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Elderly Patients with Pruritus

Aboeldahab

Khalil

El-Dawla

2021

CCID

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Introduction For elderly, pruritus is considered the most common complaint in outpatient clinic. Pruritus occurs in association with primary skin disorders and can also be caused by many diseases and drugs. The aim of the work was to study clinical and laboratory characteristics of elderly patients with pruritus in Sohag, Egypt. Patients and Methods A cross-sectional study was conducted on 225 patients aged ≥60 years of both sexes complaining of pruritus and 160 age- and sex-matched patient group complaining of non-pruritic dermatological diseases. CBC, ESR, renal function tests, serology for HBV and HCV and blood glucose levels were done routinely in all patients (both groups). Skin biopsy was done in some selected cases. Results The mean duration of pruritus was 4.23 ± 4.9 months and was generalized in 73.8% of cases with moderate severity in 35.1% with winter exacerbation in 20%. Dermatological causes of pruritus were detected in 54.2%, followed by systemic causes in 29.8%. Eczema was the most common skin cause of senile itching in 33.7%, while renal diseases were the most common systemic cause in 46.2%. Conclusion Senile pruritus is a common problem in elderly. Early and proper management is mandatory to improve their quality of life.

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“…Several cases reports also added to the evidence that Pruritis can be seen in patients with iron de iciency anaemia. This condition can be explained as the normal assembly of dermal elastic ibres is negatively affected by the decreased serum iron level, which engenders the loss/reduced skin elasticity (Tammaro et al, 2018). Discussion with the treating physician, Pruritis was con irmed.…”

Section: Case Descriptionmentioning

confidence: 98%

The role of the clinical pharmacists to improve the clinical outcomes of a kidney disease patient - A case Report

Deepalakshmi

Diya

et al. 2020

ijrps

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Pruritis is mostly presented as a warning/symptom of a few chronic diseases that may include kidney diseases. Often it can be an indication of any neurologic, systemic, psychiatric or dermatologic disorders. About 10-70% of patients with chronic renal failure, and patients undergoing dialysis exist with Pruritis. Undiagnosed Pruritis may develop into cellulitis and other complications such as septicemia. A clinical pharmacist role is crucial in managing such patients. Clinical pharmacists’ vital role towards the patient helps them manage the unhealthy condition, restore, and improve their quality of life. We had a case report of anaemia in chronic kidney disease presented with Pruritis. The treatment was going on for the severe anaemic condition. Pruritis was left undiagnosed. The treating physician accepted the intervention of the clinical pharmacist to add Epoetin-alfa 3000 units/mL thrice a week. This intervention reaffirms the role of clinical pharmacists in developing the pharmaceutical care plan for patients.

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Iron-deficiency and pruritus: a possible explanation of their relationship

Cited by 8 publications

References 4 publications

Itch in Elderly People: A Cross-sectional Study

Itch in Elderly People: A Cross-sectional Study

Clinical and Laboratory Characteristics of Elderly Patients with Pruritus

The role of the clinical pharmacists to improve the clinical outcomes of a kidney disease patient - A case Report

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