Iron deficiency and overload in men and woman of reproductive age, and pregnant women

Liu, Xiuyun; Duan, Xuexia; Tan, Dongmei; Zhang, Bin; Xu, Aiming; Qiu, Ningning; Chen, Zhaowen

doi:10.1016/j.reprotox.2023.108381

Cited by 7 publications

(4 citation statements)

References 95 publications

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“…Thus, maintaining an appropriate balance of iron within the body is paramount to ensuring optimal reproductive health and fertility in women [22,324].…”

Section: Ironmentioning

confidence: 99%

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

Kapper,

Oppelt,

Ganhör

et al. 2024

Nutrients

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The role of minerals in female fertility, particularly in relation to the menstrual cycle, presents a complex area of study that underscores the interplay between nutrition and reproductive health. This narrative review aims to elucidate the impacts of minerals on key aspects of the reproductive system: hormonal regulation, ovarian function and ovulation, endometrial health, and oxidative stress. Despite the attention given to specific micronutrients in relation to reproductive disorders, there is a noticeable absence of a comprehensive review focusing on the impact of minerals throughout the menstrual cycle on female fertility. This narrative review aims to address this gap by examining the influence of minerals on reproductive health. Each mineral’s contribution is explored in detail to provide a clearer picture of its importance in supporting female fertility. This comprehensive analysis not only enhances our knowledge of reproductive health but also offers clinicians valuable insights into potential therapeutic strategies and the recommended intake of minerals to promote female reproductive well-being, considering the menstrual cycle. This review stands as the first to offer such a detailed examination of minerals in the context of the menstrual cycle, aiming to elevate the understanding of their critical role in female fertility and reproductive health.

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“…Thus, maintaining an appropriate balance of iron within the body is paramount to ensuring optimal reproductive health and fertility in women [22,324].…”

Section: Ironmentioning

confidence: 99%

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

Kapper,

Oppelt,

Ganhör

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Clinicians can confidently diagnose haemochromatosis with targeted mutation testing of the HFE gene. This is widely available in primary care in the UK26 and internationally. Ferritin >1000 µg/L is associated with serious underlying disease including iron overload 13 Refer all patients with unexplained persistent ferritin >1000 µg/L to a hepatologist 3…”

Section: How Should I Investigate Raised Ferritin?mentioning

confidence: 99%

Section: How Should I Assess Someone With Iron Overload?mentioning

confidence: 99%

“…The role of iron in reproductive and sexual functioning is complex, with both iron deficiency and iron overload contributing to dysfunction via different mechanisms 26. Specifically, iron overload may increase the risk of infertility, subfertility,826 and sexual dysfunction (low libido, erectile dysfunction, amenorrhoea)12 through hypopituitarism, hypogonadism, direct sex organ dysfunction, and increased oxidative stress on gametes 8122631. Self-reported survey data from patients with haemochromatosis show sexual dysfunction symptom prevalence ranges from 25.8%17 to 57.3%,18 supporting the international recommendations to screen for reproductive and sexual dysfunction 12…”

Section: How Should I Assess Someone With Iron Overload?mentioning

confidence: 99%

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