Iron Deficiency and Dyserythropoiesis

Hill, Robert B.; Pettit, John E.; Tattersall, Martin H. N.; Kiley, Nancy; Lewis, S. M.

doi:10.1111/j.1365-2141.1972.tb07085.x

Cited by 23 publications

(11 citation statements)

References 14 publications

(5 reference statements)

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“…However, when the anaemia becomes more chronic, erythropoiesis can be decreased. Dyserythropoiesis, correlated with the severity of iron deficiency, can be seen as nuclear irregularities, increased karyorrhexis and erythroblast multinuclearity 41 . In cases of additional thrombocytopenia, megakaryocytes are reported to be decreased, adequate or increased 36 .…”

Section: Iron Deficiency Anaemiamentioning

confidence: 99%

The pathology of bone marrow failure

Leguit

Tweel

2010

Histopathology

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Leguit R J & van den Tweel J G (2010) Histopathology 57, 655–670 The pathology of bone marrow failure An important indication for bone marrow investigation is the presence of bone marrow failure, which manifests itself as (pan)cytopenia. The causes of cytopenia are varied and differ considerably between childhood and adulthood. In the paediatric age group inherited bone marrow failure syndromes are important causes of bone marrow failure, but they play only a minor role in later life. This review gives a comprehensive overview of bone marrow failure disorders in children and adults. We classified the causes of bone marrow failure according to the main presenting haematological abnormality, i.e. anaemia, neutropenia, thrombocytopenia or pancytopenia. The following red cell disorders are discussed: red cell aplasia, sideroblastic anaemia, congenital dyserythropoietic anaemia, haemolytic anaemia, paroxysmal nocturnal haemoglobinuria, iron deficiency anaemia, anaemia of chronic disease and megaloblastic anaemia. The neutropenias occur in the context of Shwachman–Diamond syndrome (SDS), severe congenital neutropenia, cyclic neutropenia, immune‐related neutropenia and non‐immune neutropenia. In addition, the following causes of thrombocytopenia are discussed: congenital amegakaryocytic thrombocytopenia, thrombocytopenia with absent radii, immune‐related thrombocytopenia and non‐immune thrombocytopenia. Finally, we pay attention to the following pancytopenic disorders: Fanconi anaemia, dyskeratosis congenita, aplastic anaemia, myelodysplastic syndromes and human immunodeficiency virus (HIV) infection.

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Section: Iron Deficiency Anaemiamentioning

confidence: 99%

The pathology of bone marrow failure

Leguit

Tweel

2010

Histopathology

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“…Iron deficiency is usually included among the known causes of acquired dyserythropoiesis [ 11. The degree and type of iron deficiency associated dyserythropoietic phenomena have been studied by light microscopy [2,3]. In addition, some TEM descriptions of erythropoietic cells in iron deficiency have been performed [4-61.…”

Section: Introductionmentioning

confidence: 99%

Dyserythropoiesis in iron‐deficiency anemia: Ultrastructural reassessment

et al. 1992

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Iron deficiency is usually included among the causes of acquired dyserythropoiesis. This concept was derived mainly from light microscopic studies. To reassess such a notion at ultrastructural level, a transmission electron microscopic evaluation of bone marrow was performed in seven patients with iron-deficiency anemia. In contrast to the widely accepted concept, derived from light microscopic studies, only a small proportion (2-4%, not different from controls) of erythroblasts displayed some of the features of nuclear dyserythropoiesis. On the contrary, when examining the cytoplasm, we found a significantly increased number of void ropheocytotic vesicles in the majority of late erythroblasts as compared to controls (P less than 0.001). This feature may be considered as an ultrastructural marker of iron deficiency and is consistent with the present knowledge on transferrin-mediated delivery of iron to the cell.

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“…Dyserythropoiesis, particularly cytoplasmic features, e.g. vacuolation, have been described in iron deficiency (Hill et al 1972) and the degree of dyserythropoiesis correlated with the severity of iron deficiency. Even though we excluded the cytoplasmic features from our assessment, nuclear features of dyserythropoiesis were also common in children with IDA (Figure 2b), but the degree of nuclear dyserythropoiesis did not correlate with the severity of iron deficiency.…”

Section: Crjc Newton Et Al Anaemia In Children In a Malaria Endemic mentioning

confidence: 99%

Severe anaemia in children living in a malaria endemic area of Kenya

Newton

Warn

Winstanley

et al. 1997

Tropical Med Int Health

155

137

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SummarySevere anaemia is an important cause of morbidity and mortality in African children, but the causes, particularly falciparum malaria, are difficult to determine. We assessed the contribution of falciparum malaria to anaemia in Kenyan children by clinical examination and measurement of parasitaemia and haemoglobin (Hb) concentration in 559 children in the community and in 2412 children admitted to Kilifi district hospital during a 2-year period. We also attempted to characterize severe malarial anaemia by examining the causes and pathophysiology of anaemia in 101 children admitted with Hb concentration^50 g/l during a 1-year period. Plasmodium falciparum infection was associated with reduced Hb concentration in children in the community and in those admitted to hospital irrespective of diagnosis. Falciparum malaria was the primary cause in 46 cases (46%) of severe anaemia admitted to hospital. There was no difference in the frequency of haemolysis or dyserythropoiesis in the children with malarial anaemia and those with anaemia from other causes, such as iron deficiency or sickle cell disease. The mortality rate in the children with severe malarial anaemia was 8.6% compared with 3.6% in children with severe anaemia due to other causes. Falciparum malaria does not present with a characteristic clinical or haematological picture, but is a major cause of the morbidity and mortality in children with severe anaemia who live on the Kenyan coast, a malaria endemic area.

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Iron Deficiency and Dyserythropoiesis

Cited by 23 publications

References 14 publications

The pathology of bone marrow failure

The pathology of bone marrow failure

Dyserythropoiesis in iron‐deficiency anemia: Ultrastructural reassessment

Severe anaemia in children living in a malaria endemic area of Kenya

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